Entrez Gene

Basic Information
Gene ID	5606
Name	MAP2K3
Synonymous	mitogen-activated protein kinase kinase 3;MAP2K3;mitogen-activated protein kinase kinase 3
Definition	MAP kinase kinase 3\|MAPK/ERK kinase 3\|MAPKK 3\|MEK 3\|SAPK kinase 2\|dual specificity mitogen-activated protein kinase kinase 3\|stress-activated protein kinase kinase 2
Position	17q11.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
MKK3(h) + ATP --TAK1(m)--> MKK3(h){p} + ADP (phosphorylation)
MKK3(h) + ATP --MLK2(h)--> MKK3(h){p} + ADP (phosphorylation)
Smad7(h) + MKK3(h) <==> Smad7(h):MKK3(h) (binding)
Smad7(h) + MKK3(h) + p38(h) <==> Smad7(h):MKK3(h):p38(h) (binding)
MKK3(h) + NTP --MLTK-isoform1(m)--> MKK3(h){p} + NDP (phosphorylation)
MKK3(h) + NTP --MLTK-isoform2(m)--> MKK3(h){p} + NDP (phosphorylation)
MKK3(h) + p38alpha(h) <==> MKK3(h):p38alpha(h) (binding)
MKK3(h) + Dyrk1B(h) <==> MKK3(h):Dyrk1B(h) (binding)
MKK3(h) + 2 ATP --MEKK3(v.s.)--> MKK3(h){pS189}{pT193} + 2 ADP (phosphorylation)
MKK3(h) --> BIRC3(h) (transactivation)
MKK3(h) + ATP --> MKK3(h){p} + ADP (phosphorylation)
ASK1(h) + MKK3(h) <==> ASK1(h):MKK3(h) (binding)
MKK3(h) --> DEFB4(h) (transactivation)
MKK3(h) --> Beta-defensin2(h) (increase of secretion)
ASK1(h) --> MKK3(h) (activation)
MAP2K3(h) --> MKK3(h) (expression).
MAP2K3(h) --> MKK3-isoform1(h) (expression).
MAP2K3(h) --> MKK3-isoform2(h) (expression).
MAP2K3(h) --> MKK3-isoform3(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
218	Phosphoserine.		Swiss-Prot 53.0
222	Phosphothreonine.		Swiss-Prot 53.0
218	Phosphoserine (MAP2K3)	7839144	Phospho.ELM 6.0
222	Phosphothreonine (MAP2K3)	7839144	Phospho.ELM 6.0

Transcription Factors [Top]