| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5591 |
Name | PRKDC |
Synonymous | protein kinase, DNA-activated, catalytic polypeptide;PRKDC;protein kinase, DNA-activated, catalytic polypeptide |
Definition | DNA-PK catalytic subunit|DNA-dependent protein kinase catalytic subunit|hyper-radiosensitivity of murine scid mutation, complementing 1|p460 |
Position | 8q11 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | DNA-PKcs(h) + PKCdelta(h) <==> DNA-PKcs(h):PKCdelta(h) (binding) | PKCdelta-CF(h) + DNA-PKcs(h) <==> DNA-PKcs(h):PKCdelta-CF(h) (binding) | DNA-PKcs(h) + Ku70(h) <==> DNA-PK(h) (binding) | DNA-PKcs(h) --Caspase-3(h)--> DNA-PKcsCL2(h) + DNA-PKcsCL1(h) (processing) | HSF1(h) + DNA-PKcs(h) <==> HSF1(h):DNA-PKcs(h) (binding) | ASC-2(h) + DNA-PKcs(h) <==> ASC-2(h):DNA-PKcs(h) (binding) | DNA-PKcs(h) + AID(m) <==> DNA-PKcs(h):AID(m) (binding) | DNA-PKcs(h) + MGMT(h) <==> DNA-PKcs(h):MGMT(h) (binding) | DNA-PKcs(h) + AR-isoform1(h) <==> DNA-PKcs(h):AR-isoform1(h) (binding) | DNA-PKcs(h) + Ku80(h) + Ku70(h) + AR(h) <==> DNA-PKcs(h):Ku80(h):Ku70(h):AR(h) (binding) | DNA-PKcs(h) + 6 ATP --> DNA-PKcs(h){pT2609}{pT2620}{pT2638}{pT2647}{pS2612}{pS2624} + 6 ADP (phosphorylation; automodification) | ErbB1(h) + DNA-PKcs(h) <==> ErbB1(h):DNA-PKcs(h) (binding) | ErbB1(h){pY} + DNA-PKcs(h) <==> ErbB1(h){pY}:DNA-PKcs(h) (binding) | DNA-PKcs(h) + TIF2(h) <==> DNA-PKcs(h):TIF2(h) (binding) | DNA-PKcs(h) + RCOR1(h) <==> DNA-PKcs(h):RCOR1(h) (binding) | DNA-PKcs(h) --> DNA-PKcs(h) (translocation) | PRKDC(h) --> DNA-PKcs(h) (expression). | DNA-PKcs(h) --> DNA-PKcs(h) (translocation) | PCNA(h) + DNA-PKcs-isoform1(h) <==> PCNA(h):DNA-PKcs-isoform1(h) (binding) | PRKDC(h) --> DNA-PKcs-isoform1(h) (expression). | PRKDC(h) --> DNA-PKcs-isoform2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 2603 | Phosphothreonine. | Swiss-Prot 53.0 | 2609 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 2612 | Phosphoserine (by autocatalysis). | Swiss-Prot 53.0 | 2638 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 2647 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 2649 | Phosphothreonine. | Swiss-Prot 53.0 | 3205 | Phosphoserine. | Swiss-Prot 53.0 | 2609 | Phosphothreonine (DNA-PK) | 12186630;15302935;15677476;15258142 | Phospho.ELM 6.0 | 2612 | Phosphoserine (DNA-PK) | 12186630;15302935;15677476;15258142 | Phospho.ELM 6.0 | 2638 | Phosphothreonine (DNA-PK) | 12186630;15302935;15677476;15258142 | Phospho.ELM 6.0 | 2647 | Phosphothreonine (DNA-PK) | 12186630;15302935;15677476;15258142 | Phospho.ELM 6.0 | 2624 | Phosphoserine | 12186630;15677476;15258142 | Phospho.ELM 6.0 | 2620 | Phosphothreonine (DNA-PK) | 12186630;15677476;15258142 | Phospho.ELM 6.0 | 3205 | Phosphoserine | 12186630;15302935;15677476;15258142;17081983 | Phospho.ELM 6.0 | 2056 | Phosphoserine (DNA-PK) | 15677476 | Phospho.ELM 6.0 | 2603 | Phosphothreonine | 16565220 | Phospho.ELM 6.0 | 2649 | Phosphothreonine | 16565220 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for PRKDC | ||