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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

5451

Name

POU2F1

Synonymous

POU class 2 homeobox 1;POU2F1;POU class 2 homeobox 1

Definition

NF-A1|OTF-1|Octamer-binding transcription factor-1|POU domain, class 2, transcription factor 1|oct-1|octamer-binding protein 1|octamer-binding transcription factor 1

Position

1q24.2

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

Oct-1(h) --> IgH(m) (DNA binding).
Oct-1(h) --> RNU4C(h) (DNA binding).
Oct-1(h) --> HLA-DRA(h) (DNA binding).
Oct-1(h) --> GLOB-AG(h) (DNA binding).
Oct-1(h) --> IGHG1(h) (DNA binding).
AR(m) + Oct-1(h) <==> AR(m):Oct-1(h) (binding)
AML3(v.s.) + Oct-1(h) <==> AML3(v.s.):Oct-1(h) (binding)
SRC-1A(h) + Oct-1(h) <==> SRC-1A(h):Oct-1(h) (binding)
SRC-1A(h) + AR(m) + Oct-1(h) <==> SRC-1A(h):AR(m):Oct-1(h) (binding)
Oct-1(h) + OCA-B(h) <==> Oct-1(h):OCA-B(h) (binding)
Oct-1(h) + Pbx1b(m) <==> Oct-1(h):Pbx1b(m) (binding)
Pbx1b(h) + Oct-1(h) <==> Pbx1b(h):Oct-1(h) (binding)
Prep1(h) + Oct-1(h) <==> Prep1(h):Oct-1(h) (binding)
Oct-1(h) + SMRT-xbb2(h) <==> Oct-1(h):SMRT-xbb2(h) (binding)
2 Oct-1(h) <==> (Oct-1(h))2 (oligomerization)
Oct-1(h) + NF-YA(h) <==> Oct-1(h):NF-YA(h) (binding)
Oct-1(h) + brca1(h) <==> Oct-1(h):brca1(h) (binding)
NF-1A(m) + Oct-1(h) <==> NF-1A(m):Oct-1(h) (binding)
NF-1B2(m) + Oct-1(h) <==> NF-1B2(m):Oct-1(h) (binding)
NFIC1A(m) + Oct-1(h) <==> NFIC1A(m):Oct-1(h) (binding)
NFIX2(m) + Oct-1(h) <==> NFIX2(m):Oct-1(h) (binding)
Oct-1(h) + NPAT(h) <==> Oct-1(h):NPAT(h) (binding)
GAPD(h) + Oct-1(h) <==> GAPD(h):Oct-1(h) (binding)
STIP1(h) + Oct-1(h) <==> STIP1(h):Oct-1(h) (binding)
NDKA(h) + Oct-1(h) <==> NDKA(h):Oct-1(h) (binding)
NDPKB(h) + Oct-1(h) <==> NDPKB(h):Oct-1(h) (binding)
Oct-1(h) + Grg-5(m) <==> Oct-1(h):Grg-5(m) (binding)
Oct-1(h) + Grg4(m) <==> Oct-1(h):Grg4(m) (binding)
Oct-1(h) + Msx-1(m) <==> Oct-1(h):Msx-1(m) (binding)
Oct-1(h) --> CYP2A6(h) (DNA binding; transactivation).
Sox2(m.s.) + Oct-1(h) <==> Sox2(m.s.):Oct-1(h) (binding)
Oct-1(h) --> Cdx2(m) (DNA binding; transactivation).
Oct-1(h) --> GNRHR(h) (DNA binding; transactivation).
Oct-1(h) --> TNF(h) (DNA binding).
Oct-1(h) --> uPA(h) (DNA binding).
Oct-1(h) --> CLC(h) (DNA binding).
Oct-1(h) --> Gba(h) (DNA binding).
ATF-2(h) + Oct-1(h) <==> ATF-2(h):Oct-1(h) (binding)
Oct-1(h) --> IL2(h) (DNA binding).
Oct-1(h) --> prl(h) (DNA binding).
Oct-1(h) --> GADD45A(h) (DNA binding).
Oct-1(h) --> FGFR2(h) (DNA binding).
Oct-1(h) --> DSIPI(h) (DNA binding).
Oct-1(h) --> CRP(h) (DNA binding).
Oct-1(h) --> TFAP2A(h) (DNA binding).
Oct-1(h) --> Aldh3a1(m) (DNA binding).
Oct-1(h) --> BAT1(h) (DNA binding).
Oct-1(h) --> Cyp4a11(r) (DNA binding).
Oct-1(h) --> TLR4(h) (DNA binding).
Oct-1(h) --> Rpe65(m) (DNA binding).
Oct-1(h) + Sp1-isoform1(m) <==> Oct-1(h):Sp1-isoform1(m) (binding)
Oct-1(h) --> CYP1A1(h) (DNA binding).
Oct-1(h) --> NQO1(h) (DNA binding).
Oct-1(h) --> CYP2B6(h) (DNA binding).
Oct-1(h) --> CYP2C9(h) (DNA binding).
Oct-1(h) --> CYP2C8(h) (DNA binding).
Oct-1(h) --> CYP2J2(h) (DNA binding).
Oct-1(h) --> PTPN6(h) (DNA binding).
Oct-1(h) --> BCL2(h) (DNA binding).
Oct-1(h) --> NXNL1(h) (transactivation)
Oct-1(h) --> CDKN2B(h) (DNA binding).
Oct-1(h) --> RASGRP2(h) (DNA binding).
POU2F1(h) --> Oct-1(h) (expression).
TFIIB(m.s.) --> Oct-1(h) (binding)
LDL(h){ox} --> Oct-1(h) (increase of abundance)
MAT1(h) + POU2F1(h) <==> MAT1(h):POU2F1(h) (binding)
MO15(h) + POU2F1(h) <==> MO15(h):POU2F1(h) (binding)
cyclinH(h) + POU2F1(h) <==> cyclinH(h):POU2F1(h) (binding)
TFIIH-p90(h) + POU2F1(h) <==> TFIIH-p90(h):POU2F1(h) (binding)
TFIIH-p62(h) + POU2F1(h) <==> TFIIH-p62(h):POU2F1(h) (binding)
POU2F1(h) + ATP --TFIIH-CAK(h)--> POU2F1(h){p} + ADP (phosphorylation)
POU2F1(h) + ATP --PKAc(b)--> POU2F1(h){p} + ADP (phosphorylation)
POU2F1(h) --> H2B-alpha(PM) (DNA binding).
POU2F1(h) --> IE-1(HSV1) (DNA binding).
POU2F1(h) --> IE-3(HSV1) (DNA binding).
POU2F1(h) --> RNU2(h) (DNA binding).
POU2F1(h) --> Il2(m) (DNA binding; transregulation).
POU2F1(h) --> IL3(h) (DNA binding; transactivation).
POU2F1(h) --> junD(m) (DNA binding).
POU2F1(h) --> IGHA1(h) (DNA binding).
POU2F1(h) --> HBB(h) (DNA binding).
POU2F1(h) --> GLOB-AG(h) (DNA binding).
POU2F1(h) --> IgH(m) (DNA binding).
POU2F1(h) --> Ig-kappa(m) (DNA binding).
POU2F1(h) --> Ig-kappa(h) (DNA binding).
POU2F1(h) --> LPL(h) (DNA binding).
POU2F1(h) --> IE-2(HSV1) (DNA binding).
POU2F1(h) --> c-myc(h) (DNA binding).
POU2F1(h) --> ori(AD2) (DNA binding).
POU2F1(h) --> S gene(HBV) (DNA binding).
POU2F1(h) --> IE(PRV) (DNA binding).
POU2F1(h) --> lyn(h) (DNA binding).
POU2F1(h) --> ori(AD4) (DNA binding).
POU2F1(h) --> E1A(AD5) (DNA binding).
POU2F1(h) --> H2B(h) (DNA binding).
POU2F1(h) --> H2B(c) (DNA binding).
POU2F1(h) --> IE-4/5(HSV1) (DNA binding).
POU2F1(h) --> IL2(h) (DNA binding).
POU2F1(h) --> SV40(sv) (DNA binding).
POU2F1(h) --> U2 snRNA(x) (DNA binding).
POU2F1(h) --> Cd79b(m) (DNA binding).
POU2F1(h) --> Scgb1a1(r) (DNA binding).
HCF1-isoform1(h) + POU2F1(h) <==> HCF1-isoform1(h):POU2F1(h) (binding).
TBP(h) + POU2F1(h) <==> TBP(h):POU2F1(h) (binding).
POU2F2(fc) + POU2F1(h) <==> POU2F2(fc):POU2F1(h) (binding).
Oct-2(RAT) + POU2F1(h) <==> Oct-2(RAT):POU2F1(h) (binding).
CCF(h) + POU2F1(h) <==> CCF(h):POU2F1(h) (binding).
OCA-B(h) + POU2F1(h) <==> OCA-B(h):POU2F1(h) (binding).
Vmw65(HSV1) + POU2F1(h) <==> Vmw65(HSV1):POU2F1(h) (binding).
POU2F1(h) --> Sfpi1(m) (DNA binding; transactivation).
POU2F1(h) --> IL-5(h) (DNA binding; transactivation).
POU2F1(h) --> Sst(r) (DNA binding).
POU2F1(h) --> IVL(h) (DNA binding).
STAT5A(s) + POU2F1(h) <==> STAT5A(s):POU2F1(h) (binding)
STAT5A(m) + POU2F1(h) <==> STAT5A(m):POU2F1(h) (binding)
STAT5A(h) + POU2F1(h) <==> STAT5A(h):POU2F1(h) (binding)
STAT5B(h) + POU2F1(h) <==> STAT5B(h):POU2F1(h) (binding)
POU2F1(h) --> CCND1(h) (DNA binding; transactivation).
POU2F1(h) --> NAT1(h) (DNA binding).
RXR-alpha(h) + POU2F1(h) <==> RXR-alpha(h):POU2F1(h) (binding)
CREB1(m.s.) + POU2F1(h) <==> CREB1(m.s.):POU2F1(h) (binding)
POU2F1(h) + CREB1(h) <==> POU2F1(h):CREB1(h) (binding)
POU2F1(h) + ATF-1(m.s.) <==> POU2F1(h):ATF-1(m.s.) (binding)
POU2F1(h) --> POU2F1(h) (expression).
POU2F1(h) --> Oct-1L(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

448Phosphoserine.Swiss-Prot 53.0
448Phosphoserine15302935Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr1

Promoter: 165455267 - 165457267Agilent_014791

chr1

Promoter: 165455267 - 165457267GSE27584

chr1

Promoter: 165455267 - 165457267Agilent_014791_44K

chr1

Promoter: 165455267 - 165457267E-GEOD-20553


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