Entrez Gene

Basic Information
Gene ID	4904
Name	YBX1
Synonymous	Y box binding protein 1;YBX1;Y box binding protein 1
Definition	CBF-A\|CCAAT-binding transcription factor I subunit A\|DNA-binding protein B\|EFI-A\|Y-box transcription factor\|Y-box-binding protein 1\|enhancer factor I subunit A\|major histocompatibility complex, class II, Y box-binding protein I\|nuclease sensitive element
Position	1p34
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
YB-1B(h) --/ Vegfa(m) (DNA binding; transrepression).
YB-1B(h) + calmodulin(b) <==> YB-1B(h):calmodulin(b) (binding)
AUF1-p37(m.s.) + YB-1B(h) <==> AUF1-p37(m.s.):YB-1B(h) (binding)
AUF1-p40(m.s.) + YB-1B(h) <==> AUF1-p40(m.s.):YB-1B(h) (binding)
YBX1(h) --> YB-1B(h) (expression).
YB-1(h) --> Mmp2(r) (DNA binding; transregulation).
AP-2alphaA(h) + YB-1(h) <==> AP-2alphaA(h):YB-1(h) (binding).
YB-1(h) + YB-1(h) <==> YB-1(h):YB-1(h) (binding).
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
YB-1(h) --> SLC6A4(h) (DNA binding; transactivation).
YB-1(h) --> ABCB1(h) (DNA binding).
YBX1(h) --> YB-1(h) (expression).
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
PCNA(h) + YB-1(h) <==> PCNA(h):YB-1(h) (binding)
YB-1(h) --> ABCB1(h) (DNA binding).
brca1(m.s.) + YB-1(h) <==> brca1(m.s.):YB-1(h) (binding)
YB-1(h) --> FAS(h) (DNA binding).
AUF1-p37(m.s.) + YB-1(h) <==> AUF1-p37(m.s.):YB-1(h) (binding)
YB-1(h) + ATP --> YB-1(h){pS102} + ADP (phosphorylation)
YB-1(h) --> ErbB2(h) (increase of abundance)
YB-1(h) --> ErbB1(h) (increase of abundance)
YB-1(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation)
YB-1(h) --> ERK2(h){pT185}{pY187} (increase of abundance)
YB-1(h) --> h2ax(h){pS140} (decrease of phosphorylation)
YB-1(h) --> STAT3(h){pS727} (increase of phosphorylation)
YB-1(h) --> Mcl-1(h) (increase of abundance)
YB-1(h) --> mTOR(h) (increase of abundance)
YB-1(h) --> mTOR(h){pS2448} (increase of phosphorylation)
YB-1(h) --> GUCY1B3(h) (DNA binding).
YB-1(h) --> EGFR(h) (DNA binding).
YB-1(h) --> CCNA2(h) (DNA binding).
YB-1(h) --> CCNB1(h) (DNA binding; transactivation).
YB-1(h) --> CCL5(h) (DNA binding).
YB-1(h) --> MET(h) (DNA binding).
YB-1(h) --> SMAD7(r) (DNA binding).
YB-1(h) --> PTPN1(h) (DNA binding).
YB-1(h) --/ ABCC2(r) (DNA binding; transrepression).
YB-1(h) --> Pik3ca(h) (DNA binding).
YB-1(h) --> MMP13(h) (DNA binding).
YB-1(h) --> H2-M3(m) (DNA binding).
YB-1(h) --> ACTA2(h) (DNA binding).
YBX1(h) --> YB-1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
102	Phosphoserine (by PKB/AKT1).		Swiss-Prot 53.0
162	Phosphotyrosine.		Swiss-Prot 53.0
165	Phosphoserine (By similarity).		Swiss-Prot 53.0
174	Phosphoserine.		Swiss-Prot 53.0
176	Phosphoserine.		Swiss-Prot 53.0
314	Phosphoserine.		Swiss-Prot 53.0
161	Phosphotyrosine	15592455	Phospho.ELM 6.0
101	Phosphoserine	15806160;17081983	Phospho.ELM 6.0
164	Phosphoserine	17081983	Phospho.ELM 6.0
173	Phosphoserine	17081983	Phospho.ELM 6.0
175	Phosphoserine	17081983	Phospho.ELM 6.0
312	Phosphoserine	17081983	Phospho.ELM 6.0
313	Phosphoserine	17081983	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr1	Promoter: 42919153 - 42921153	Agilent_014791
chr1	Promoter: 42919153 - 42921153	GSE27584
chr1	Promoter: 42919153 - 42921153	Agilent_014791_44K

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]