Entrez Gene

Basic Information
Gene ID	4609
Name	MYC
Synonymous	v-myc avian myelocytomatosis viral oncogene homolog;MYC;v-myc avian myelocytomatosis viral oncogene homolog
Definition	avian myelocytomatosis viral oncogene homolog\|class E basic helix-loop-helix protein 39\|myc proto-oncogene protein\|myc-related translation/localization regulatory factor\|proto-oncogene c-Myc\|transcription factor p64\|v-myc myelocytomatosis viral oncogene h
Position	8q24.21
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
c-Myc(h) --> c-myc(h) (DNA binding).
c-Myc(h) --> ERBB2(h) (DNA binding).
c-Myc(h) --> Ptma(r) (DNA binding; transregulation).
c-Myc(h) --> ODC1(h) (DNA binding; transregulation).
c-Myc(h) --> DHFR(ha) (DNA binding).
c-Myc(h) --> Odc1(m) (DNA binding).
c-Myc(h) --> CDK4(m) (DNA binding).
c-Myc(h) --> CDK4(h) (DNA binding).
c-Myc(h) --> CXCR4(h) (DNA binding).
c-Myc(h) --> TERT(h) (DNA binding).
c-Myc(h) --> MrDb(h) (DNA binding).
c-Myc(h) --> Odc1(r) (DNA binding).
c-Myc(h) --> EIF4E(h) (DNA binding).
c-Myc(h) + p107(h) <==> c-Myc(h):p107(h) (binding).
c-Myc(h) + pRb(h) <==> c-Myc(h):pRb(h) (binding).
Max-isoform2(h) + c-Myc(h) <==> Max-isoform2(h):c-Myc(h) (binding).
Max-isoform1(h) + c-Myc(h) <==> Max-isoform1(h):c-Myc(h) (binding).
Nmi(h) + c-Myc(h) <==> Nmi(h):c-Myc(h) (binding).
MAZ(h) + c-Myc(h) <==> MAZ(h):c-Myc(h) (binding).
Max(m) + c-Myc(h) <==> Max(m):c-Myc(h) (binding).
YY1(h) + c-Myc(h) <==> YY1(h):c-Myc(h) (binding).
SSRP1(h) + c-Myc(h) <==> SSRP1(h):c-Myc(h) (binding).
Max-isoform3(h) + c-Myc(h) <==> Max-isoform3(h):c-Myc(h) (binding).
Miz-1(h) + c-Myc(h) <==> Miz-1(h):c-Myc(h) (binding).
Bin1-Isoform-1(h) + c-Myc(h) <==> Bin1-Isoform-1(h):c-Myc(h) (binding).
Max(h) + c-Myc(h) + GCN5(h) + trrap(h) <==> Max(h):c-Myc(h):GCN5(h):trrap(h) (binding)
c-Myc(h) + trrap(h) <==> c-Myc(h):trrap(h) (binding)
c-Myc(h) --> cdc25A(h) (DNA binding; transactivation).
c-Myc(h) --> B1AR(s) (DNA binding).
c-Myc(h) + Max(h) <==> c-Myc(h):Max(h) (binding) [f
AP-2alphaA(h) + c-Myc(h) <==> AP-2alphaA(h):c-Myc(h) (binding).
c-Myc(h) + c-Myc(h) <==> c-Myc(h):c-Myc(h) (binding).
JLP(m) + c-Myc(h) <==> JLP(m):c-Myc(h) (binding)
c-Myc(h) + Tiam-1(h) <==> c-Myc(h):Tiam-1(h) (binding)
c-Myc(h) + p73alpha(h) <==> c-Myc(h):p73alpha(h) (binding; interaction)
c-Myc(h) --> YBX1(h) (DNA binding; transactivation).
c-Myc(h) + 6 acetyl-CoA --p300(h)--> c-Myc(h){aceK143}{aceK157}{aceK275}{aceK317}{aceK323}{aceK371} + 6 CoA (acetylation)
c-Myc(h) + brca1(h) <==> brca1(h):c-Myc(h) (binding)
p300(m.s.) + c-Myc(h) <==> p300(m.s.):c-Myc(h) (binding)
p300(h) + c-Myc(h) <==> p300(h):c-Myc(h) (binding)
BAF47-isoformA(h) + c-Myc(h) <==> BAF47-isoformA(h):c-Myc(h) (binding)
Max(m.s.) + c-Myc(h) <==> Max(m.s.):c-Myc(h) (binding)
Tip60(h) + c-Myc(h) <==> Tip60(h):c-Myc(h) (binding)
c-Myc(h) + ATP --JNK1(h)--> c-Myc(h){p} + ADP (phosphorylation)
c-Myc(h) + ATP --ERK2(h)--> c-Myc(h){p} + ADP (phosphorylation)
c-Myc(h) + 2 ATP --JNK1beta1(m.s.)--> c-Myc(h){pS62}{pS71} + 2 ADP (phosphorylation)
c-Myc(h) + 2 ATP --JNK3(h)--> c-Myc(h){pS62}{pS71} + 2 ADP (phosphorylation)
c-Myc(h) + ATP --ERK2(m.s.)--> c-Myc(h){pS62} + ADP (phosphorylation)
c-Myc(h) + JNK1beta1(m.s.) <==> c-Myc(h):JNK1beta1(m.s.) (binding)
c-Myc(h) + JNK1(h) <==> c-Myc(h):JNK1(h) (binding)
c-Myc(h) + p21Cip1(h) <==> c-Myc(h):p21Cip1(h) (binding)
Cdk8(h) + c-Myc(h) <==> Cdk8(h):c-Myc(h) (binding)
c-Myc(h) + cyclinT1(h) <==> c-Myc(h):cyclinT1(h) (binding)
c-Myc(h) --> MIRN17(h) (DNA binding; transactivation)
c-Myc(h) --> Hmga1(m) (DNA binding; transactivation).
p16INK4a-xbb1(h) + c-Myc(h) <==> p16INK4a-xbb1(h):c-Myc(h) (binding)
c-Myc(h) + Max(m.s.) + p16INK4a-xbb1(h) <==> c-Myc(h):Max(m.s.):p16INK4a-xbb1(h) (binding)
c-Myc(h) --> c-Myc(h) (translocation)
c-Myc(h) --/ MIRN29B1(h) (DNA binding; transrepression).
c-Myc(h) --/ MIRN29A(h) (DNA binding; transrepression).
c-myc(h) --> c-Myc(h) (expression).
c-Myc(h) --> c-Myc(h) (translocation)
c-Myc(h) + Smad3(h) <==> c-Myc(h):Smad3(h) (binding)
c-Myc(h) + Smad2(h) <==> c-Myc(h):Smad2(h) (binding)
c-Myc(h) + ATP --ERK1(h)--> c-Myc(h){p} + ADP (phosphorylation)
c-Myc(h) --> TERT(h) (transregulation; DNA binding)
p300(h) + c-Myc(h) <==> p300(h):c-Myc(h) (binding)
c-Myc(h) --> TERT(h) (transactivation)
c-Myc(h) + HDAC1(h) + sin3a(h) + RNF96-isoform1(h) + MM-1(m.s.) <==> c-Myc(h):HDAC1(h):sin3a(h):RNF96-isoform1(h):MM-1(m.s.) (binding)
c-Myc(h) + BAF47-isoformA(h) <==> c-Myc(h):BAF47-isoformA(h) (binding)
c-Myc(h) + BAF47(m.s.) <==> c-Myc(h):BAF47(m.s.) (binding)
BAF47(h) + c-Myc(h) <==> BAF47(h):c-Myc(h) (binding)
c-Myc(h) + Skp2(h) <==> c-Myc(h):Skp2(h) (binding)
CBP(h) + c-Myc(h) <==> CBP(h):c-Myc(h) (binding)
PARP-10(h) + c-Myc(h) <==> PARP-10(h):c-Myc(h) (binding)
c-Myc(h) --> EIF4E(h) (DNA binding).
c-Myc(h) + ASCC3-L1(h) <==> c-Myc(h):ASCC3-L1(h) (binding)
c-Myc(h) + BAP28(h) <==> c-Myc(h):BAP28(h) (binding)
c-Myc(h) + kiaa0859(h) <==> c-Myc(h):kiaa0859(h) (binding)
c-Myc(h) + nup205(h) <==> c-Myc(h):nup205(h) (binding)
c-Myc(h) + GTBP(h) <==> c-Myc(h):GTBP(h) (binding)
c-Myc(h) + mcm7(h) <==> c-Myc(h):mcm7(h) (binding)
c-Myc(h) + POLE1(h) <==> c-Myc(h):POLE1(h) (binding)
c-Myc(h) + NUP93(h) <==> c-Myc(h):NUP93(h) (binding)
c-Myc(h) + FANCI(h) <==> c-Myc(h):FANCI(h) (binding)
c-Myc(h) + GCN1L(h) <==> c-Myc(h):GCN1L(h) (binding)
c-Myc(h) + DDX24(h) <==> c-Myc(h):DDX24(h) (binding)
c-Myc(h) + LFP40(h) <==> c-Myc(h):LFP40(h) (binding)
c-Myc(h) + Gemin-4(h) <==> c-Myc(h):Gemin-4(h) (binding)
c-Myc(h) + Prpf8(h) <==> c-Myc(h):Prpf8(h) (binding)
c-Myc(h) + p160MBP(h) <==> c-Myc(h):p160MBP(h) (binding)
c-Myc(h) + SEC8(h) <==> c-Myc(h):SEC8(h) (binding)
c-Myc(h) + TF3C-gamma(h) <==> c-Myc(h):TF3C-gamma(h) (binding)
Max(h) + c-Myc(h) <==> Max(h):c-Myc(h) (binding)
c-Myc(h) + TWA2(h) <==> c-Myc(h):TWA2(h) (binding)
c-Myc(h) + Snrp116(h) <==> c-Myc(h):Snrp116(h) (binding)
c-Myc(h) + BRG1(h) <==> c-Myc(h):BRG1(h) (binding)
c-Myc(h) + Myr1(h) <==> c-Myc(h):Myr1(h) (binding)
c-Myc(h) + hnRNP-C(h) <==> c-Myc(h):hnRNP-C(h) (binding)
c-Myc(h) + Pds5A(h) <==> c-Myc(h):Pds5A(h) (binding)
c-Myc(h) + p30 DBC(h) <==> c-Myc(h):p30 DBC(h) (binding)
c-Myc(h) --> MUC5B(h) (DNA binding).
c-Myc(h) --/ Brd7(h) (DNA binding; transrepression).
c-Myc(h) --> VEGFA(h) (DNA binding).
c-Myc(h) --> NOP16(h) (transactivation)
c-Myc(h) --> BAX(h) (transactivation)
c-Myc(h) --> CAD(h) (DNA binding).
c-Myc(h) --> HSP90AA1(h) (DNA binding).
c-myc(h) --> c-Myc(h) (expression).
TGFbeta1(m.s.) --/ c-Myc(h) (decrease of abundance)
C/EBPalpha(h) --/ c-Myc(h) (decrease of abundance)
estradiol --> c-Myc(h) (increase of abundance)
GM-CSF(m.s.) --> c-Myc(h) (increase of abundance)
Fz6(h) --/ c-Myc(h) (decrease of abundance)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
8	Phosphothreonine; by RAF; in vitro.		Swiss-Prot 53.0
58	Phosphothreonine; alternate.		Swiss-Prot 53.0
62	Phosphoserine.		Swiss-Prot 53.0
143	N6-acetyllysine; by PCAF.		Swiss-Prot 53.0
157	N6-acetyllysine; by PCAF.		Swiss-Prot 53.0
275	N6-acetyllysine; by PCAF.		Swiss-Prot 53.0
317	N6-acetyllysine; by PCAF.		Swiss-Prot 53.0
323	N6-acetyllysine; by PCAF.		Swiss-Prot 53.0
371	N6-acetyllysine; by PCAF.		Swiss-Prot 53.0
58	Phosphothreonine (GSK-3beta;GS)	11018017;14563837;15150404;17081983	Phospho.ELM 6.0
62	Phosphoserine (ERT PK;MAPK1)	91332050;1651323;17081983	Phospho.ELM 6.0
58	O-linked	Chou TY., Hart GW., Dang CV. (1995)J. Biol. Chem., 270, 18961-18965. Medline: 95370209;	OGlycBase6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr8	Promoter: 128815998 - 128817998	Agilent_014791
chr8	Promoter: 128815998 - 128817998	GSE27584
chr8	Promoter: 128815998 - 128817998	Agilent_014791
chr8	Promoter: 128815998 - 128817998	PMID:17289889

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]