| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4361 |
Name | MRE11A |
Synonymous | MRE11 meiotic recombination 11 homolog A (S. cerevisiae);MRE11A;MRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
Definition | AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A |
Position | 11q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Mre11-isoform1(h) + ATP --ATM(m.s.)--> Mre11-isoform1(h){pS264} + ADP (phosphorylation) | Mre11-isoform1(h) + 3 ATP --ATR(m.s.)--> Mre11-isoform1(h){pS264}{pS382}{pS531} + 3 ADP (phosphorylation) | Mre11-isoform1(h) + ATP --DNA-PK(m.s.)--> Mre11-isoform1(h){pS264} + ADP (phosphorylation) | MRE11A(h) --> Mre11-isoform1(h) (expression). | Mre11(h) + NBS1(h) + Rad50(h) <==> Mre11(h):NBS1(h):Rad50(h) (binding) | WS(h) + NBS1(h) + Mre11(h) + Rad50(h) <==> WS(h):Mre11(h):NBS1(h):Rad50(h) (binding) | TERF2IP(h) + TRF2(h) + Mre11(h) + Ku70(h) + Ku80(h) + PARP(h) + Rad50(h) <==> TERF2IP(h):TRF2(h):Mre11(h):Ku70(h):Ku80(h):PARP(h):Rad50(h) (binding) | Mre11(h) + TERF2IP(h) <==> Mre11(h):TERF2IP(h) (binding) | Nek1(h) + Mre11(h) <==> Nek1(h):Mre11(h) (binding) | Mre11(h) + CtIP(h) + Bach1(h) + Rad50(h) + BARD1(h) <==> Mre11(h):CtIP(h):Bach1(h):Rad50(h):BARD1(h) (binding) | Mre11(h) + NBS1(h) + Bach1(h) + Rad50(h) + TOP2BP1(h) + BARD1(h) <==> Mre11(h):NBS1(h):Bach1(h):Rad50(h):TOP2BP1(h):BARD1(h) (binding) | brca1(h) + Mre11(h) <==> brca1(h):Mre11(h) (binding) | BARD1(h) + Mre11(h) <==> BARD1(h):Mre11(h) (binding) | Mre11(h) + NBS1(h) + CtIP(h) + Rad50(h) + brca1(h) <==> Mre11(h):NBS1(h):CtIP(h):Rad50(h):brca1(h) (binding) | Mre11(h) + Rad50(h) <==> Mre11(h):Rad50(h) (binding) | ATM(h) + Mre11(h) <==> ATM(h):Mre11(h) (binding) | NBS1(h) + Rad50(h) + Mre11(h) + h2ax(h){pS140} <==> NBS1(h):Rad50(h):Mre11(h):h2ax(h){pS140} (binding) | Mre11(h) + p300(h) <==> Mre11(h):p300(h) (binding) | Mre11(h) --> Chk1(h){pS317} (increase of phosphorylation) | RPA2(h) + Mre11(h) <==> RPA2(h):Mre11(h) (binding) | Mre11(h) --> NBS1(h) (increase of abundance) | Mre11(h) --> Rad50(h) (increase of abundance) | MRE11A(h) --> Mre11(h) (expression). | MRE11A(h) --> Mre11-isoform2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 74 | Phosphothreonine. | Swiss-Prot 53.0 | 688 | Phosphoserine. | Swiss-Prot 53.0 | 689 | Phosphoserine. | Swiss-Prot 53.0 | 688 | Phosphoserine | 15302935;16083285;17081983 | Phospho.ELM 6.0 | 689 | Phosphoserine | 15302935;16083285;17081983 | Phospho.ELM 6.0 | 74 | Phosphothreonine | 15302935 | Phospho.ELM 6.0 | 264 | Phosphoserine (ATM) | 10608806 | Phospho.ELM 6.0 | 649 | Phosphoserine | 15845385 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 93866188 - 93868188 | GSE27584 |
chr11 |
Promoter: 93866188 - 93868188 | GSE27584 |
chr11 |
Promoter: 93866188 - 93868188 | Agilent_014791_44K |
chr11 |
Promoter: 93866188 - 93868188 | Agilent_014791 |