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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

4085

Name

MAD2L1

Synonymous

MAD2 mitotic arrest deficient-like 1 (yeast);MAD2L1;MAD2 mitotic arrest deficient-like 1 (yeast)

Definition

MAD2 (mitotic arrest deficient, yeast, homolog)-like 1|MAD2-like protein 1|mitotic arrest deficient 2-like protein 1|mitotic arrest deficient, yeast, homolog-like 1|mitotic spindle assembly checkpoint protein MAD2A

Position

4q27

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

InsR(h) + MAD2(h) <==> InsR(h):MAD2(h) (binding)
Cdc27(h){p}n + MAD2(h) <==> Cdc27(h){p}n:MAD2(h) (binding)
Cdc27(h) + Cdc20(h) + MAD2(h) <==> Cdc27(h):Cdc20(h):MAD2(h) (binding)
MAD2(h) + MAD1(h) <==> MAD2(h):MAD1(h) (binding)
Cdc20(h) + MAD2(h) <==> Cdc20(h):MAD2(h) (binding)
MAD1(h) + MAD2(h) <==> MAD1(h):MAD2(h) (binding)
APC7(h) + Cdc20(h) + MAD2(h) + Bub3(h) + BubR1(h) <==> APC7(h):Cdc20(h):MAD2(h):Bub3(h):BubR1(h) (binding)
Cdc20(h) + MAD2(h) + Bub3(h) + BubR1(h) <==> Cdc20(h):MAD2(h):Bub3(h):BubR1(h) (binding)
cyclosome(h) + Cdc20(h) + MAD2(h) + BubR1(h) <==> cyclosome(h):Cdc20(h):MAD2(h):BubR1(h) (binding)
p31-comet(h) + Cdc27(h) + Cdc20(h) + MAD2(h) <==> p31-comet(h):Cdc27(h):Cdc20(h):MAD2(h) (binding)
p31-comet(h) + MAD2(h) <==> p31-comet(h):MAD2(h) (binding)
MAD2(h) + Cdc20(h) <==> MAD2(h):Cdc20(h) (binding)
DustyPK(h) + MAD2(h) <==> DustyPK(h):MAD2(h) (binding)
MAD2(h) + Tilz2(h) <==> MAD2(h):Tilz2(h) (binding)
MAD2(h) + IL-5Rbeta(h) <==> MAD2(h):IL-5Rbeta(h) (binding)
MAD2L1(h) --> MAD2(h) (expression).
cyclosome(h):Cdc20(h){ub}n:MAD2(h):BubR1(h) <==> cyclosome(h):Cdc20(h){ub}n + MAD2(h) + BubR1(h) (dissociation)
securin(fy) + n ubiquitin(b) --E1(m),E2-C(h),cyclosome(m):Cdc20(h){p}--> securin(fy){ub(n)} (ubiquitination)
cyclinB(h) + n ubiquitin(b) --E1(m),E2-C(h),cyclosome(m):Cdc20(h){p}--> cyclinB(h){ub(n)} (ubiquitination)
MAD2(h) + Cdc20(h) <==> MAD2(h):Cdc20(h) (binding)
MAD2(h) + MAD1(h) <==> MAD2(h):MAD1(h) (binding)
4 MAD2(h) <==> (MAD2(h))4 (oligomerization)
2 MAD2(h) <==> (MAD2(h))2 (oligomerization)
MAD2L1(h) --> MAD2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

170Phosphoserine12574116Phospho.ELM 6.0
178Phosphoserine12574116Phospho.ELM 6.0
195Phosphoserine12574116Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr4

Promoter: 121206911 - 121208911Agilent_014791

chr4

Promoter: 121206911 - 121208911GoldenGate_Methylation_Cancer_Panel_I

chr4

Promoter: 121206911 - 121208911GSE27584

chr4

Promoter: 121206911 - 121208911Agilent_014791_44K


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