| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4000 |
Name | LMNA |
Synonymous | lamin A/C;LMNA;lamin A/C |
Definition | 70 kDa lamin|lamin|lamin A/C-like 1|prelamin-A/C|renal carcinoma antigen NY-REN-32 |
Position | 1q22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | lamin-A(h) --Caspase-6(h)--> protein remnants (processing) | PKCalpha(r) + lamin-A(h) <==> PKCalpha(r):lamin-A(h) (binding) | lamin-A(h) --Caspase-3(h)--> protein remnants (cleavage) | lamin-A(h) + Tip60(h) <==> lamin-A(h):Tip60(h) (binding) | LMNA(h) --> lamin-A(h) (expression). | LMNA(h) --> lamin A-xbb1(h) (expression). | LMNA(h) --> LaminA-xbb2(h) (expression). | LMNA(h) --> LaminA-xbb3(h) (expression). | LMNA(h) --> LaminA-xbb4(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 1 | Blocked amino end (Met). | Swiss-Prot 53.0 | 10 | Phosphothreonine. | Swiss-Prot 53.0 | 12 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 19 | Phosphothreonine. | Swiss-Prot 53.0 | 22 | Phosphoserine. | Swiss-Prot 53.0 | 277 | Phosphoserine. | Swiss-Prot 53.0 | 390 | Phosphoserine. | Swiss-Prot 53.0 | 392 | Phosphoserine. | Swiss-Prot 53.0 | 395 | Phosphoserine. | Swiss-Prot 53.0 | 407 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 417 | N6-acetyllysine. | Swiss-Prot 53.0 | 424 | Phosphothreonine. | Swiss-Prot 53.0 | 496 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 505 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 507 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 510 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 628 | Phosphoserine. | Swiss-Prot 53.0 | 632 | Phosphoserine. | Swiss-Prot 53.0 | 636 | Phosphoserine. | Swiss-Prot 53.0 | 652 | Phosphoserine. | Swiss-Prot 53.0 | 661 | S-farnesyl cysteine (By similarity). | Swiss-Prot 53.0 | 392 | Phosphoserine | 95010153;15302935;16083285;17081983 | Phospho.ELM 6.0 | 390 | Phosphoserine | 15302935;16083285;17081983 | Phospho.ELM 6.0 | 525 | Phosphoserine | 93238752 | Phospho.ELM 6.0 | 406 | Phosphoserine | 16083285 | Phospho.ELM 6.0 | 407 | Phosphoserine | 16083285;17081983 | Phospho.ELM 6.0 | 409 | Phosphothreonine | 16083285 | Phospho.ELM 6.0 | 423 | Phosphoserine | 16083285 | Phospho.ELM 6.0 | 10 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 277 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 395 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 414 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 424 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 628 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 636 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 154349622 - 154351622 | Agilent_014791 |
chr1 |
Promoter: 154349622 - 154351622 | GSE27584 |
chr1 |
Promoter: 154349622 - 154351622 | GSE27584 |
chr1 |
Promoter: 154349622 - 154351622 | GSE27584 |
chr1 |
Promoter: 154349622 - 154351622 | Agilent_014791_44K |
chr1 |
Promoter: 154349622 - 154351622 | E-GEOD-20553 |
chr1 |
Promoter: 154349622 - 154351622 | E-GEOD-20553 |
chr1 |
Promoter: 154349622 - 154351622 | E-GEOD-20553 |
chr1 |
Promoter: 154349622 - 154351622 | PMID:15867203 |
chr1 |
Promoter: 154349622 - 154351622 | PMID:15867203 |
chr1 |
Promoter: 154349622 - 154351622 | PMID:15867203 |