| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3845 |
Name | KRAS |
Synonymous | Kirsten rat sarcoma viral oncogene homolog;KRAS;Kirsten rat sarcoma viral oncogene homolog |
Definition | GTPase KRas|K-Ras 2|K-ras p21 protein|PR310 c-K-ras oncogene|c-Ki-ras|c-Kirsten-ras protein|cellular c-Ki-ras2 proto-oncogene|oncogene KRAS2|transforming protein p21|v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog |
Position | 12p12.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | KRAS(h) --> K-Ras A(h) (expression). | KRAS(h) --> K-Ras2 B(h) (expression). | KRAS(h) --> KRAS(h) (expression). | hsa-let-7a --/ KRAS(h) (predicted) | hnRNP-C(h) + K-Ras(h) <==> hnRNP-C(h):K-Ras(h) (binding) | KRAS(h) --> K-Ras(h) (expression). | PDGFB(m.s.) --> K-Ras(h) (increase of abundance) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 180 | S-palmitoyl cysteine. | Swiss-Prot 53.0 | 186 | Cysteine methyl ester; in isoform 2A. | Swiss-Prot 53.0 | 186 | S-farnesyl cysteine; in isoform 2A. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 25294621 - 25296621 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 25294621 - 25296621 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 25294621 - 25296621 | GSE27584 |
chr12 |
Promoter: 25294621 - 25296621 | GSE27584 |
chr12 |
Promoter: 25294621 - 25296621 | Agilent_014791_44K |
chr12 |
Promoter: 25294621 - 25296621 | PMID:12615722 |
chr12 |
Promoter: 25294621 - 25296621 | PMID:12615722 |