| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3691 |
Name | ITGB4 |
Synonymous | integrin, beta 4;ITGB4;integrin, beta 4 |
Definition | CD104 antigen|GP150|integrin beta-4|integrin beta-4 subunit |
Position | 17q25 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | beta4-integrin(h) + ATP --PKCalpha(h)--> beta4-integrin(h){pS1360}{pS1364} + ADP (phosphorylation) | beta4-integrin(h) --> Abl(m.s.){p} (decrease of phosphorylation) | beta4-integrin(h) --> MAPK(m.s.){p} (decrease of phosphorylation) | beta4-integrin(h) --> Abl(h){pY} (decrease of phosphorylation) | beta4-integrin(h) --> p73(h):Abl(h) (increase of binding) | beta4-integrin(h) + ErbB2(h) <==> beta4-integrin(h):ErbB2(h) (binding) | beta4-integrin(h) --> ErbB1(h){p} (increase of phosphorylation) | beta4-integrin(h) --> ErbB2(h){p} (increase of phosphorylation) | beta4-integrin(h) --> eIF-4E(h){p} (increase of phosphorylation) | ErbB2(m.s.) + beta4-integrin(h) <==> ErbB2(m.s.):beta4-integrin(h) (binding) | clca2-p90(h) + beta4-integrin(h) <==> clca2-p90(h):beta4-integrin(h) (binding) | clca2(h) + beta4-integrin(h) <==> clca2(h):beta4-integrin(h) (binding) | beta4-integrin(h) + ATP --> beta4-integrin(h){pY} + ADP (phosphorylation) | beta4-integrin(h) + beta6-integrin(h) <==> beta4-integrin(h):beta6-integrin(h) (binding) | ITGB4(h) --> beta4-integrin(h) (expression). | ITGB4(h) --> Beta-4C(h) (expression). | Beta-4A(h) + vimentin(h) <==> Beta-4A(h):vimentin(h) (binding) | ITGB4(h) --> Beta-4A(h) (expression). | ITGB4(h) --> Beta-4B(h) (expression). | ITGB4(h) --> Beta-4D(h) (expression). | ITGB4(h) --> Beta-4E(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 327 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 491 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 579 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 617 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 695 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 1207 | Phosphotyrosine. | Swiss-Prot 53.0 | 1530 | Phosphothreonine. | Swiss-Prot 53.0 | 1364 | Phosphoserine (PKC alpha) | 15121854 | Phospho.ELM 6.0 | 1207 | Phosphotyrosine | 15951569 | Phospho.ELM 6.0 | 1257 | Phosphotyrosine | 11438664 | Phospho.ELM 6.0 | 1564 | Phosphotyrosine | 11438664 | Phospho.ELM 6.0 | 1356 | Phosphoserine (PKC alpha) | 15121854 | Phospho.ELM 6.0 | 1360 | Phosphoserine (PKC alpha) | 15121854 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 71227611 - 71229611 | Agilent_014791 |
chr17 |
Promoter: 71230871 - 71232871 | Agilent_014791 |
chr17 |
Promoter: 71227611 - 71229611 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 71227611 - 71229611 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 71230871 - 71232871 | GSE27584 |
chr17 |
Promoter: 71227611 - 71229611 | GSE27584 |
chr17 |
Promoter: 71227611 - 71229611 | GSE27584 |