| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3576 |
Name | CXCL8 |
Synonymous | chemokine (C-X-C motif) ligand 8;CXCL8;chemokine (C-X-C motif) ligand 8 |
Definition | T-cell chemotactic factor|alveolar macrophage chemotactic factor I|beta endothelial cell-derived neutrophil activating peptide|beta-thromboglobulin-like protein|emoctakin|granulocyte chemotactic protein 1|interleukin 8|interleukin-8|lung giant cell carcin |
Position | 4q13-q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IL-8(h) + CXCR1(h) <==> IL-8(h):CXCR1(h) (binding) | IL-8(h) + CXCR2(h) <==> IL-8(h):CXCR2(h) (binding) | heparin + IL-8(h) <==> heparin:IL-8(h) (binding) | CXCR1(h) + IL-8(h) <==> CXCR1(h):IL-8(h) (binding) | IL-8(h) + CXCR2(h) <==> IL-8(h):CXCR2(h) (binding) | IL-8(h) --> CXCR1(h){p} (increase of phosphorylation) | IL-8(h) --> CXCR2(h){p} (increase of phosphorylation) | IL-8(h) --> ERK1(r){p} (increase of phosphorylation) | IL-8(h) --> ERK2(r){p} (increase of phosphorylation) | 2 IL-8(h) <==> (IL-8(h))2 (binding; oligomerization) | IL-17E(h) --> IL-8(h) (activation) | IL8(h) --> IL-8(h) (expression). | Nod2(h) --> IL-8(h) (increase of secretion) | 15-HETE --/ IL-8(h) (decrease of abundance) | 13-HODE --/ IL-8(h) (decrease of abundance) | 15d-PGJ2 --/ IL-8(h) (decrease of abundance) | 5(S)-HETE --/ IL-8(h) (decrease of abundance) | 13-OxoODE --/ IL-8(h) (decrease of abundance) | Caspase-4(h) --> IL-8(h) (increase of secretion) | CD89(h) --> IL-8(h) (increase of secretion) | TLR4(m.s.):MD-2(m.s.) --> IL-8(h) (increase of abundance) | RP105(h):MD-1(h) --/ IL-8(h) (decrease of abundance) | RP105(h):MD-1(h) --> IL-8(h) (increase of abundance) | beta-arrestin1(m.s.) --> IL-8(h) (decrease of secretion) | TGFalpha(h) --/ IL-8(h) (decrease of abundance) | Nod2(m.s.) --> IL-8(h) (increase of abundance) | AKAP13(h) --> IL-8(h) (increase of abundance) | CAP18-LL-37(h) --> IL-8(h) (increase of abundance) | GM-CSF(m.s.) --> IL-8(h) (increase of abundance) | thrombin(b) --> IL-8(h) (increase of secretion) | TNF-alpha(m.s.) --> IL-8(h) (increase of secretion) | IFNgamma(h) --/ IL-8(h) (decrease of abundance) | IFNgamma(h) --> IL-8(h) (increase of secretion) | IL-17F(h) --> IL-8(h) (increase of secretion) | TGFalpha(h) --> IL-8(h) (increase of secretion) | IL-17A(h) --> IL-8(h) (increase of secretion) | IL-17A(h):IL-17F(h) --> IL-8(h) (increase of secretion) | TRAM(h) --> IL-8(h) (decrease of secretion) | TNF(m.s.) --> IL-8(h) (increase of secretion) | IL-1(m.s.) --> IL-8(h) (increase of secretion) | p85(m.s.) --> IL-8(h) (increase of secretion) | IL-17A(m.s.) --> IL-8(h) (increase of secretion) | TLR5(h) --> IL-8(h) (increase of secretion) | Prkcm(h) --> IL-8(h) (increase of secretion) | IL-1beta(h) --> IL-8(h) (increase of secretion) | H2O2 --> IL-8(h) (increase of secretion) | flagellin(SALTY) --> IL-8(h) (increase of secretion) | IL-22(h) --> IL-8(h) (increase of abundance) | poly(I:C) --> IL-8(h) (increase of secretion) | ET-1(m.s.) --> IL-8(h) (increase of secretion) | ET3(m.s.) --> IL-8(h) (increase of secretion) | TNF-alpha(h) --> IL-8(h) (increase of abundance) | PAR2(h) --> IL-8(h) (increase of abundance) | IFNgamma(h) --> IL-8(h) (increase of abundance) | HD-5(h) --> IL-8(h) (increase of secretion) | curdlan --> IL-8(h) (increase of secretion) | IL-8-isoform1(h) + CXCR1(rb) <==> IL-8-isoform1(h):CXCR1(rb) (binding) | IL8(h) --> IL-8-isoform1(h) (expression). | IL8(h) --> IL-8-isoform2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for CXCL8 | |||
Methylation Profile [Top] | ||
There is no record for CXCL8 | ||