| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3458 |
Name | IFNG |
Synonymous | interferon, gamma;IFNG;interferon, gamma |
Definition | IFN-gamma|immune interferon|interferon gamma |
Position | 12q14 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IFNgamma(h) --> SMAD7(h) (transactivation) | IFNgamma(h) --> INCA(h) (transactivation). | IFNgamma(h) --> Stat1(m.s.){sumo} (increase of sumoylation) | IFNgamma(h) --> PRKR(h) (transactivation) | IFNgamma(h) + CRT(h) <==> IFNgamma(h):CRT(h) (binding) | IFNgamma(h) --> SOCS3(h) (transactivation) | IFNgamma(h) --> STAT1(h){pY} (increase of phosphorylation) | IFNgamma(h) --> IFI27(h) (transactivation) | IFNgamma(h) --> BST2(h) (transactivation) | IFNgamma(h) --> STAT1(h) (increase of abundance) | IFNgamma(h) --> EPSTI1(h) (transactivation) | IFNgamma(h) --> HERC6(h) (transactivation) | IFNgamma(h) --> PLSCR1(h) (transactivation) | IFNgamma(h) --> IFIT1(h) (transactivation) | IFNgamma(h) --> ISG15(h) (transactivation) | IFNgamma(h) --> IRF7(h) (transactivation) | IFNgamma(h) --> MX1(h) (transactivation) | IFNgamma(h) --> IFIT3(h) (transactivation) | IFNgamma(h) --> IFI35(h) (transactivation) | IFNgamma(h) --> IFITM1(h) (transactivation) | IFNgamma(h) --> IFIH1(h) (transactivation) | IFNgamma(h) --> IFI44L(h) (transactivation) | IFNgamma(h) --> IFI44(h) (transactivation) | IFNgamma(h) --> STAT1(h) (transactivation) | IFNgamma(h) --> OAS3(h) (transactivation) | IFNgamma(h) --> OAS2(h) (transactivation) | IFNgamma(h) --> OAS1(h) (transactivation) | IFNgamma(h) --> PLAUR(h) (transactivation) | IFNgamma(h) --> uPAR(h) (increase of abundance) | IFNG(h) --> IFNgamma(h) (expression). | NKp30(h) --> IFNgamma(h) (increase of abundance) | NKp46(h) --> IFNgamma(h) (increase of abundance) | MICA(m.s.) --> IFNgamma(h) (increase of abundance) | ULBP1(m.s.) --> IFNgamma(h) (increase of abundance) | HCV-Core protein-1A-H(HCV1AH) --/ IFNgamma(h) (decrease of abundance) | SOCS-1(h) --/ IFNgamma(h) (decrease of abundance) | SOCS-3(h) --/ IFNgamma(h) (decrease of abundance) | CD80(h) --> IFNgamma(h) (increase of secretion) | LAB72(h) --> IFNgamma(h) (increase of secretion) | CD28(h) --> IFNgamma(h) (increase of secretion) | LPG(LEIMA) --> IFNgamma(h) (increase of abundance) | NTB-A(m.s.) --> IFNgamma(h) (increase of secretion) | S1P --> IFNgamma(h) (increase of secretion) | IL-18(h) --> IFNgamma(h) (increase of secretion) | IL-12(m.s.) --> IFNgamma(h) (increase of abundance) | 3pRNA --> IFNgamma(h) (increase of secretion) | ZAP-70(h) --> IFNgamma(h) (increase of secretion) | IFNgamma(h) --> MEKK4(h){pY} (increase of phosphorylation) | IFNgamma(h) --> annexin-A2(h):MEKK4(h) (increase of binding) | IFNgamma(h) --> MEKK4(h):Pyk2(h) (increase of binding) | IFNgamma(h) --> Pyk2(h){pY} (increase of phosphorylation) | IFNgamma(h) --> MKK6(m.s.){p} (increase of phosphorylation) | IFNgamma(h) --> MEKK4(h){p} (increase of phosphorylation) | IFNgamma(h) --> p38(h){p} (increase of phosphorylation) | IFNgamma(h) --> ATF-2(m.s.){p} (increase of phosphorylation) | IFNgamma(h) --> MEKK4(h):SHP-2(h) (increase of binding) | IFNgamma(h) --> PML(h) (increase of abundance) | IFNgamma(h) --> Jak2(m){ub}n (increase of ubiquitination) | IFNgamma(h) --> Jak2(m) (increase of cleavage) | IFNgamma(h) --> STAT1(h){pY} (increase of phosphorylation) | IFNgamma(h) --> PIAS1(m){pS90} (increase of phosphorylation) | IFNgamma(h) --> Cxcl9(m) (transactivation) | IFNgamma(h) --> Cxcl10(m) (transactivation) | IFNgamma(h) --> Irf1(m) (transactivation) | IFNgamma(h) --> ErbB1(h){pY} (increase of phosphorylation) | IFNgamma(h) --> ERK(h){p} (increase of phosphorylation) | IFNgamma(h) --> IFNGR(h){p} (increase of phosphorylation) | IFNgamma(h) --> CCL2(h) (transactivation) | IFNgamma(h) --> CCL5(h) (transactivation) | IFNgamma(h) --> CXCL10(h) (transactivation) | IFNgamma(h) --> IL8(h) (transactivation) | IFNgamma(h) --> TLR2(h) (transactivation) | IFNgamma(h) --> TLR4(h) (transactivation) | IFNgamma(h) --/ TLR5(h) (transrepression) | IFNgamma(h) --/ TLR9(h) (transrepression) | IFNgamma(h) --> TLR5(h) (transactivation) | IFNgamma(h) --> STAT1(h){pY701} (increase of phosphorylation) | IFNgamma(h) --> SOCS1(h) (transactivation) | IFNgamma(h) --> SOCS-1(h) (increase of abundance) | IFNgamma(h) --> ERK1(h){pY204} (increase of phosphorylation) | IFNgamma(h) --> ERK2(h){pY187} (increase of phosphorylation) | IFNgamma(h) --> Elk-1(m.s.){p} (increase of phosphorylation) | IFNgamma(h) --> IP-10(h) (increase of abundance) | IFNgamma(h) --> MCP-1(h) (increase of abundance) | IFNgamma(h) --/ IL-8(h) (decrease of abundance) | IFNgamma(h) --> Elk-1(h){p} (increase of phosphorylation) | IFNgamma(h) --> MEK1(m.s.){p} (increase of phosphorylation) | IFNgamma(h) --> RasGAP(h):SOCS-1(h) (increase of binding) | IFNgamma(h) --> IP-10(h) (increase of secretion) | IFNgamma(h) --> Jak1(h){p} (increase of phosphorylation) | IFNgamma(h) --> Jak2(h){p} (increase of phosphorylation) | IFNgamma(h) --> IL-1beta(h) (increase of secretion) | IFNgamma(h) --> IL-4(h) (increase of secretion) | IFNgamma(h) --> IL-5(h) (increase of secretion) | IFNgamma(h) --> IL-6(h) (increase of secretion) | IFNgamma(h) --> IL-8(h) (increase of secretion) | IFNgamma(h) --> IL-13(h) (increase of secretion) | IFNgamma(h) --> TNF-alpha(h) (increase of secretion) | IFNgamma(h) --> IL-1beta(m) (increase of secretion) | IFNgamma(h) --> IL-4(m) (increase of secretion) | IFNgamma(h) --> IL-5(m) (increase of secretion) | IFNgamma(h) --> IL-6(m) (increase of secretion) | IFNgamma(h) --> IL-13(m) (increase of secretion) | IFNgamma(h) --> TNF-alpha(m) (increase of secretion) | IFNgamma(h) --> IL1B(h) (transactivation) | IFNgamma(h) --> IL-4(h) (transactivation) | IFNgamma(h) --> IL-5(h) (transactivation) | IFNgamma(h) --> IL6(h) (transactivation) | IFNgamma(h) --> IL13(h) (transactivation) | IFNgamma(h) --> TNF(h) (transactivation) | IFNgamma(h) --> Il1b(m) (transactivation) | IFNgamma(h) --> Il4(m) (transactivation) | IFNgamma(h) --> IL-5(m) (transactivation) | IFNgamma(h) --> Il6(m) (transactivation) | IFNgamma(h) --> IL13(m) (transactivation) | IFNgamma(h) --> Tnf(m) (transactivation). | IFNgamma(h) --> STAT1(h){pY701}{pS727} (increase of phosphorylation) | IFNgamma(h) --> Jak1(m){p} (increase of phosphorylation) | IFNgamma(h) --> Jak2(m){p} (increase of phosphorylation) | IFNgamma(h) --> STAT1(m){pY701}{pS727} (increase of phosphorylation) | IFNgamma(h) --> PKCalpha(h){p} (increase of phosphorylation) | IFNgamma(h) --> PKCbeta1(h){p} (increase of phosphorylation) | IFNgamma(h) --> PKCalpha(m){p} (increase of phosphorylation) | IFNgamma(h) --> PKCbeta(m){p} (increase of phosphorylation) | IFNgamma(h) --> JNK(h){p} (increase of phosphorylation) | IFNgamma(h) --> p38(m){p} (increase of phosphorylation) | IFNgamma(h) --> JNK(m){p} (increase of phosphorylation) | IFNgamma(h) --> ERK(m){p} (increase of phosphorylation) | IFNgamma(h) --/ SLC26A6(h) (transrepression) | IFNgamma(h) --/ ABCA1(h) (transrepression) | IFNgamma(h) --/ ABC-1(h) (decrease of abundance) | IFNgamma(h) --/ NR1H3(h) (transrepression) | IFNgamma(h) --/ LXR-alpha(h) (decrease of abundance) | IFNgamma(h) --> VEGF-A(h) (decrease of secretion) | IFNgamma(h) --> VEGFR-1(h) (increase of secretion). | IFNgamma(h) --> FLT1(h) (transactivation) | IFNgamma(h) + IFNGR(h) + IFNGR2(h) <==> IFNgamma(h):IFNGR(h):IFNGR2(h) (binding) | IFNGR(h) + IFNgamma(h) <==> IFNGR(h):IFNgamma(h) (binding) | IFNgamma(h) --> TGFB1(h) (transactivation) | IFNgamma(h) --> TGFB2(h) (transactivation) | IFNgamma(h) --> TGFbeta1(h) (increase of secretion) | IFNgamma(h) --> TGFbeta2(h) (decrease of secretion) | IFNgamma(h) --/ FCGRT(h) (transrepression) | IFNgamma(h) --/ FCRN(h) (decrease of abundance) | IFNgamma(h) --> PIAS1(m.s.):STAT1alpha(h) (increase of binding) | IFNgamma(h) --> STAT1alpha(h){pY701}{pS727} (increase of phosphorylation) | IFNgamma(h) --> p300(h):STAT1alpha(h) (increase of binding) | IFNgamma(h) --/ SLC2A4(h) (transrepression) | IFNgamma(h) --/ IRS1(h) (transrepression) | IFNgamma(h) --/ IRS-1(h) (decrease of abundance) | IFNgamma(h) --/ PPARG(h) (transrepression) | IFNgamma(h) --/ ADIPOQ(h) (transrepression) | IFNgamma(h) --/ LPL(h) (transrepression) | IFNgamma(h) --/ FASN(h) (transrepression) | IFNgamma(h) --> STAT1(h){p} (increase of phosphorylation) | IFNgamma(h) --> STAT3(h){p} (increase of phosphorylation) | IFNgamma(h) --> SOCS3(h) (transactivation) | IFNgamma(h) --/ IRS1(m) (transrepression) | IFNgamma(h) --> Socs1(m) (transactivation) | IFNgamma(h) --> Socs3(m) (transactivation) | IFNgamma(h) --> CIITA(h) (transactivation) | IFNgamma(h) --> HLA-DRA(h) (transactivation) | IFNgamma(h) --> Ciita(m) (transactivation) | IFNgamma(h) --> Cd40(m) (transactivation) | IFNgamma(h) --> GBP1(h) (transactivation) | IFNgamma(h) --> IRF1(h) (transactivation) | IFNgamma(h) --> STAT1(h) (transactivation) | IFNgamma(h) --> Tap1(h) (transactivation) | IFNgamma(h) --> GTP cyclohydrolase I(h) (increase of abundance) | IFNgamma(h) --> 6-pyruvoyl tetrahydrobiopterin synthase(h) (increase of abundance) | IFNgamma(h) --> GCH1(h) (transactivation) | IFNgamma(h) --> STAT1(m){pY701} (increase of phosphorylation) | IFNgamma(h) --> STAT3(h){pY705} (increase of phosphorylation) | IFNgamma(h) --> irf2(h) (increase of abundance) | IFNgamma(h) --> irf1(h) (increase of abundance) | IFNgamma(h) --> PSMB9(h) (transactivation) | IFNgamma(h) --> PSMB8(h) (transactivation) | IFNgamma(h) --> Jak1(h){pY} (increase of phosphorylation) | IFNgamma(h) --> Jak1(h) (increase of abundance) | IFNgamma(h) --> Jak2(h) (increase of abundance) | IFNgamma(h) --> Jak2(h){pY} (increase of phosphorylation) | IFNgamma(h) --> Asp2(h) (increase of abundance) | IFNgamma(h) --> NOS2(h) (transactivation) | IFNgamma(h) --> c-Cbl(h){pY} (increase of phosphorylation) | IFNgamma(h) --> CrkL(h){pY} (increase of phosphorylation) | IFNgamma(h) --> CrkL(h):c-Cbl(h){pY} (increase of binding) | IFNgamma(h) --> STAT5(h){pY} (increase of phosphorylation) | IFNgamma(h) --> Rap1(h):GTP (increase of abundance) | IFNgamma(h) --> c-Cbl(h):CrkL(m.s.) (increase of binding) | IFNgamma(h) --> PKCdelta(h){pT507} (increase of phosphorylation) | IFNgamma(h) --> histone H1(m.s.){p} (increase of phosphorylation) | IFNgamma(h) --> STAT1(h):PKCdelta(h) (increase of binding) | IFNgamma(h) --> STAT1(h){pS727} (increase of phosphorylation) | IFNgamma(h) --> Hsp27(m.s.){p} (increase of phosphorylation) | IFNgamma(h) --> ICAM1(h) (transactivation) | IFNgamma(h) --> STAT1(h){pY701}:Src(h) (increase of binding) | IFNgamma(h) --> Src(h){pY} (increase of phosphorylation) | IFNgamma(h) --> STAT1(h):Src(h){pY} (increase of binding) | IFNgamma(h) --> PLCgamma(h){pY} (increase of phosphorylation) | IFNgamma(h) --> Jak1(h):PLCgamma(h) (increase of binding) | IFNgamma(h) --> Jak2(h):PLCgamma(h) (increase of binding) | IFNgamma(h) --> Jak1(h):STAT1(h) (increase of binding) | IFNgamma(h) --> Jak2(h):STAT1(h) (increase of binding) | IFNgamma(h) --> STAT1(h):Jak1(h){pY} (increase of binding) | IFNgamma(h) --> STAT1(h):Jak2(h){pY} (increase of binding) | IFNgamma(h) --> IL18BP(h) (transactivation) | IFNgamma(h) --> TLR7(h) (transactivation) | IFNgamma(h) --> TLR8(h) (transactivation) | IFNgamma(h) --> IL-8(h) (increase of abundance) | IFNgamma(h) --> Bcl-2(h) (increase of abundance) | IFNgamma(h) --> IRF8(h) (transactivation) | IFNG(h) --> IFNgamma(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 24 | Pyrrolidone carboxylic acid. | Swiss-Prot 53.0 | 48 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 120 | N-linked (GlcNAc...); in dimeric form. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for IFNG | ||