| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2130 |
Name | EWSR1 |
Synonymous | EWS RNA-binding protein 1;EWSR1;EWS RNA-binding protein 1 |
Definition | EWS RNA-binding protein variant 6|Ewing sarcoma breakpoint region 1|Ewings sarcoma EWS-Fli1 (type 1) oncogene|RNA-binding protein EWS |
Position | 22q12.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | EWS(h) + STRAP(m.s.) <==> EWS(h):STRAP(m.s.) (binding) | EWS(h) + STRAP(h) <==> EWS(h):STRAP(h) (binding) | EWS(h) --> FOS(h) (transactivation) | EWS(h) --> c-Fos(h) (increase of abundance) | p300(m.s.) + EWS(h) <==> p300(m.s.):EWS(h) (binding) | SPF30(h) + EWS(h) <==> SPF30(h):EWS(h) (binding) | RhoGDI-1(h) + EWS(h) <==> RhoGDI-1(h):EWS(h) (binding) | SIAHBP1(h) + EWS(h) <==> SIAHBP1(h):EWS(h) (binding) | GSK3beta(h) + EWS(h) <==> GSK3beta(h):EWS(h) (binding) | ILK(h) + EWS(h) <==> ILK(h):EWS(h) (binding) | CD2BP2(h) + EWS(h) <==> CD2BP2(h):EWS(h) (binding) | BAF53a(h) + EWS(h) <==> BAF53a(h):EWS(h) (binding) | angiotensinogen(h) + EWS(h) <==> angiotensinogen(h):EWS(h) (binding) | bad(h) + EWS(h) <==> bad(h):EWS(h) (binding) | BNIP3L(h) + EWS(h) <==> BNIP3L(h):EWS(h) (binding) | CEA(h) + EWS(h) <==> CEA(h):EWS(h) (binding) | cetp(h) + EWS(h) <==> cetp(h):EWS(h) (binding) | cxadr(h) + EWS(h) <==> cxadr(h):EWS(h) (binding) | ICAD(h) + EWS(h) <==> ICAD(h):EWS(h) (binding) | HUC(h) + EWS(h) <==> HUC(h):EWS(h) (binding) | HuD(h) + EWS(h) <==> HuD(h):EWS(h) (binding) | EWS(h) + fasn(h) <==> EWS(h):fasn(h) (binding) | EWS(h) + HMGIY(h) <==> EWS(h):HMGIY(h) (binding) | EWS(h) + BKbeta(h) <==> EWS(h):BKbeta(h) (binding) | EWS(h) + ECE3(h) <==> EWS(h):ECE3(h) (binding) | EWS(h) + smad4(h) <==> EWS(h):smad4(h) (binding) | EWS(h) + MAGE11(h) <==> EWS(h):MAGE11(h) (binding) | EWS(h) + CHK(h) <==> EWS(h):CHK(h) (binding) | EWS(h) + I-MF(h) <==> EWS(h):I-MF(h) (binding) | EWS(h) + mtcp1(h) <==> EWS(h):mtcp1(h) (binding) | EWS(h) + myosinIF(h) <==> EWS(h):myosinIF(h) (binding) | EWS(h) + trim37(h) <==> EWS(h):trim37(h) (binding) | EWS(h) + mevalonate kinase(h) <==> EWS(h):mevalonate kinase(h) (binding) | EWS(h) + LC17(h) <==> EWS(h):LC17(h) (binding) | EWS(h) + NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1(h) <==> EWS(h):NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1(h) (binding) | EWS(h) + NADH dehydrogenase (ubiquinone) flavoprotein 1, mitochondrial(h) <==> EWS(h):NADH dehydrogenase (ubiquinone) flavoprotein 1, mitochondrial(h) (binding) | EWS(h) + BNP(h) <==> EWS(h):BNP(h) (binding) | EWS(h) + PLSCR1(h) <==> EWS(h):PLSCR1(h) (binding) | EWS(h) + Rad23A(h) <==> EWS(h):Rad23A(h) (binding) | EWS(h) + rpl31(h) <==> EWS(h):rpl31(h) (binding) | EWS(h) + rps15a(h) <==> EWS(h):rps15a(h) (binding) | EWS(h) + Sall2(h) <==> EWS(h):Sall2(h) (binding) | EWS(h) + EAAC1(h) <==> EWS(h):EAAC1(h) (binding) | EWS(h) + YL-1(h) <==> EWS(h):YL-1(h) (binding) | EWS(h) + TUBL2(h) <==> EWS(h):TUBL2(h) (binding) | EWS(h) + CT53(h) <==> EWS(h):CT53(h) (binding) | EWS(h) + E3BP(h) <==> EWS(h):E3BP(h) (binding) | EWS(h) + TB4Y(h) <==> EWS(h):TB4Y(h) (binding) | EWS(h) + msc(h) <==> EWS(h):msc(h) (binding) | EWS(h) + Herp(h) <==> EWS(h):Herp(h) (binding) | EWS(h) + glucosamine-6-phosphate isomerase(h) <==> EWS(h):glucosamine-6-phosphate isomerase(h) (binding) | EWS(h) + Tspan-3(h) <==> EWS(h):Tspan-3(h) (binding) | EWS(h) + Bucentaur(h) <==> EWS(h):Bucentaur(h) (binding) | EWS(h) + LIR-4(h) <==> EWS(h):LIR-4(h) (binding) | EWS(h) + rbpms(h) <==> EWS(h):rbpms(h) (binding) | EWS(h) + CFIM68(h) <==> EWS(h):CFIM68(h) (binding) | EWS(h) + AIP5(h) <==> EWS(h):AIP5(h) (binding) | EWS(h) + wwp2(h) <==> EWS(h):wwp2(h) (binding) | EWS(h) + HRB2(h) <==> EWS(h):HRB2(h) (binding) | EWS(h) + wdr37(h) <==> EWS(h):wdr37(h) (binding) | EWS(h) + Nlp(h) <==> EWS(h):Nlp(h) (binding) | EWS(h) + Ssdp2(h) <==> EWS(h):Ssdp2(h) (binding) | EWS(h) + 6-phosphogluconolactonase(h) <==> EWS(h):6-phosphogluconolactonase(h) (binding) | EWS(h) + PGs2(h) <==> EWS(h):PGs2(h) (binding) | EWS(h) + C10orf12(h) <==> EWS(h):C10orf12(h) (binding) | EWS(h) + MRP-S18b(h) <==> EWS(h):MRP-S18b(h) (binding) | EWS(h) + DHHC3(h) <==> EWS(h):DHHC3(h) (binding) | EWS(h) + calsarcin-1(h) <==> EWS(h):calsarcin-1(h) (binding) | EWS(h) + Nle(h) <==> EWS(h):Nle(h) (binding) | EWS(h) + HSD8(h) <==> EWS(h):HSD8(h) (binding) | EWS(h) + mns1(h) <==> EWS(h):mns1(h) (binding) | EWS(h) + TRPV5(h) <==> EWS(h):TRPV5(h) (binding) | EWS(h) + c11orf16(h) <==> EWS(h):c11orf16(h) (binding) | EWS(h) + HHGP(h) <==> EWS(h):HHGP(h) (binding) | EWS(h) + NB1(h) <==> EWS(h):NB1(h) (binding) | EWS(h) + SP192(h) <==> EWS(h):SP192(h) (binding) | EWS(h) + Dmrt6(h) <==> EWS(h):Dmrt6(h) (binding) | EWS(h) + rmnd5B(h) <==> EWS(h):rmnd5B(h) (binding) | EWS(h) + rasl11B(h) <==> EWS(h):rasl11B(h) (binding) | EWS(h) + C8orf9(h) <==> EWS(h):C8orf9(h) (binding) | EWS(h) + cuedc2(h) <==> EWS(h):cuedc2(h) (binding) | EWS(h) + c19orf50(h) <==> EWS(h):c19orf50(h) (binding) | EWS(h) + c19orf57(h) <==> EWS(h):c19orf57(h) (binding) | EWS(h) + histone-lysine N-methyltransferase, H3 lysine-9 specific 2(h) <==> EWS(h):histone-lysine N-methyltransferase, H3 lysine-9 specific 2(h) (binding) | EWS(h) + cpsf7(h) <==> EWS(h):cpsf7(h) (binding) | EWS(h) + AE2(h) <==> EWS(h):AE2(h) (binding) | EWS(h) + PEPP-2(h) <==> EWS(h):PEPP-2(h) (binding) | EWS(h) + LMNT2(h) <==> EWS(h):LMNT2(h) (binding) | EWS(h) + ethanolaminephosphotransferase 1(h) <==> EWS(h):ethanolaminephosphotransferase 1(h) (binding) | EWS(h) + mapk1ip1l(h) <==> EWS(h):mapk1ip1l(h) (binding) | EWS(h) + ralyl(h) <==> EWS(h):ralyl(h) (binding) | EWS(h) + rnf183(h) <==> EWS(h):rnf183(h) (binding) | EWS(h) + DLC2(h) <==> EWS(h):DLC2(h) (binding) | EWS(h) + prune2(h) <==> EWS(h):prune2(h) (binding) | EWS(h) + c1orf71(h) <==> EWS(h):c1orf71(h) (binding) | EWS(h) + SLM-1(h) <==> EWS(h):SLM-1(h) (binding) | EWS(h) + ccdc7(h) <==> EWS(h):ccdc7(h) (binding) | EWS(h) + slc22a24(h) <==> EWS(h):slc22a24(h) (binding) | EWS(h) + RAB37(h) <==> EWS(h):RAB37(h) (binding) | EWS(h) + FAM131C(h) <==> EWS(h):FAM131C(h) (binding) | EWS(h) + nsun4(h) <==> EWS(h):nsun4(h) (binding) | EWS(h) + serp2(h) <==> EWS(h):serp2(h) (binding) | EWS(h) + HCG3(h) <==> EWS(h):HCG3(h) (binding) | ddx1(h) + DDX3(h) + p72(h) + p68(h) + DDX15(h) + NF45(h) + HNRPH1(h) + EWS(h) + TDP43(h) + RN3(m.s.) + HNRPUL1(h) + raly(h) + SRPK1(h) + taf15(h) + TLS(h) + JKTBP(h) + hnRNPM(h) + SAF-A(h) + DRBP76(h) + Gy1(h) <==> ddx1(h):DDX3(h):p72(h):p68(h):DDX15(h):NF45(h):HNRPH1(h):EWS(h):TDP43(h):RN3(m.s.):HNRPUL1(h):raly(h):SRPK1(h):taf15(h):TLS(h):JKTBP(h):hnRNPM(h):SAF-A(h):DRBP76(h):Gy1(h) (binding) | RN3(m.s.) + p72(h) + hnRNPM(h) + EWS(h) <==> RN3(m.s.):p72(h):hnRNPM(h):EWS(h) (binding) | EWS(h) --> PLD2(h) (transactivation) | EWSR1(h) --> EWS(h) (expression). | EWSR1(h) --> EWS(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 266 | Phosphoserine (by PKC) (By similarity). | Swiss-Prot 53.0 | 300 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 302 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 304 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 309 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 314 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 317 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 321 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 455 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 464 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 471 | Asymmetric dimethylarginine; alternate. | Swiss-Prot 53.0 | 471 | Omega-N-methylarginine; alternate. | Swiss-Prot 53.0 | 490 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 494 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 500 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 503 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 506 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 563 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 565 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 572 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 575 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 581 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 589 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 592 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 596 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 600 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 603 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 607 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 615 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 633 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 | 636 | Asymmetric dimethylarginine. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr22 |
Promoter: 27992517 - 27994517 | GSE27584 |
chr22 |
Promoter: 27992517 - 27994517 | GSE27584 |
chr22 |
Promoter: 27992517 - 27994517 | Agilent_014791_44K |