| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 19 |
Name | ABCA1 |
Synonymous | ATP-binding cassette, sub-family A (ABC1), member 1;ABCA1;ATP-binding cassette, sub-family A (ABC1), member 1 |
Definition | ATP-binding cassette sub-family A member 1|ATP-binding cassette transporter A1|cholesterol efflux regulatory protein|membrane-bound |
Position | 9q31.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ABCA1(h) --> ABC-1(h) (expression). | FADD(h) + ABC-1(h) <==> FADD(h):ABC-1(h) (binding) | ABC-1(h) + serine palmitoyltransferase 1(h) <==> ABC-1(h):serine palmitoyltransferase 1(h) (binding) | ABCA1(h) --> ABC-1(h) (expression). | N-WASP(m.s.) --> ABC-1(h) (activation) | Cdc42(m.s.) --> ABC-1(h) (activation) | 22beta-hydroxycholesterol --> ABC-1(h) (increase of abundance) | TR1 --> ABC-1(h) (increase of abundance) | IFNgamma(h) --/ ABC-1(h) (decrease of abundance) | rab8a(h) --> ABC-1(h) (increase of abundance) | rab8a(h) --> ABC-1(h) (increase of abundance) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 14 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 98 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 151 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 161 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 196 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 244 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 292 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 337 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 349 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 400 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 478 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 489 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 521 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 820 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1042 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 1141 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1144 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1147 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1294 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1453 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1504 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1637 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2044 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 2054 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 2238 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1286 | Phosphothreonine | 12869555 | Phospho.ELM 6.0 | 1242 | Phosphothreonine (CK2 alpha) | 15218032 | Phospho.ELM 6.0 | 1243 | Phosphothreonine (CK2 alpha) | 15218032 | Phospho.ELM 6.0 | 1255 | Phosphoserine (CK2 alpha) | 15218032 | Phospho.ELM 6.0 | 1305 | Phosphothreonine | 12869555 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr9 |
Promoter: 106729757 - 106731757 | Agilent_014791 |
chr9 |
Promoter: 106729757 - 106731757 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 106729757 - 106731757 | GSE27584 |
chr9 |
Promoter: 106729757 - 106731757 | Agilent_014791_44K |