| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1839 |
Name | HBEGF |
Synonymous | heparin-binding EGF-like growth factor;HBEGF;heparin-binding EGF-like growth factor |
Definition | diphtheria toxin receptor (heparin-binding EGF-like growth factor)|diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)|heparin-binding epidermal growth factor|proheparin-binding EGF-like growth factor |
Position | 5q23 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | HB-EGF(h) + ErbB4(h) <==> HB-EGF(h):ErbB4(h) (binding) | HB-EGF(h) + ErbB1(h) <==> HB-EGF(h):ErbB1(h) (binding) | HB-EGF(h) --stromelysin1(h)--> HB-EGF-ECD(h) + protein remnants (processing; cleavage) | HB-EGF(h) --TACE(m)--> HB-EGF-ECD(h) + protein remnants (processing; cleavage) | HB-EGF(h) + ErbB2(m.s.):ErbB4(m) <==> HB-EGF(h):ErbB2(m.s.):ErbB4(m) (binding) | HB-EGF(h) + (ErbB1(m.s.))2 <==> (ErbB1(m.s.))2:HB-EGF(h) (binding) | HB-EGF(h) + ErbB1(m.s.):ErbB2(m.s.) <==> HB-EGF(h):ErbB1(m.s.):ErbB2(m.s.) (binding) | HB-EGF(h) --> RSK1(r){p} (increase of phosphorylation) | HB-EGF(h) --> ERK1(r){pT203}{pY205} (increase of phosphorylation) | HB-EGF(h) --> ERK2(r){pT183}{pY185} (increase of phosphorylation) | HB-EGF(h) --> Shc(r){p} (increase of phosphorylation) | HB-EGF(h) --TACE(h)--> HB-EGF-p17(h) + protein remnants (cleavage) | HB-EGF(h) --adam10(h)--> HB-EGF-p16.4(h) + protein remnants (cleavage) | HB-EGF(h) --TACE(h)--> HB-EGF-p16(h) + protein remnants (cleavage) | HB-EGF(h) --adam10(h)--> HB-EGF-p15(h) + protein remnants (cleavage) | HB-EGF(h) --> ERK1(h){p} (increase of phosphorylation) | HB-EGF(h) --> ERK2(h){p} (increase of phosphorylation) | HBEGF(h) --> HB-EGF(h) (expression). | adiponectin(m) + HB-EGF(h) <==> adiponectin(m):HB-EGF(h) (binding) | HB-EGF(h) --> p38alpha(h){pT180}{pY182} (increase of phosphorylation) | HB-EGF(h) --> HB-EGF-ECD(h) + protein remnants (processing) | HB-EGF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | HB-EGF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | HBEGF(h) --> HB-EGF(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 75 | O-linked (GalNAc...). | Swiss-Prot 53.0 | 85 | O-linked (GalNAc...). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 139705858 - 139707858 | Agilent_014791 |
chr5 |
Promoter: 139705858 - 139707858 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 139705858 - 139707858 | GSE27584 |
chr5 |
Promoter: 139705858 - 139707858 | Agilent_014791_44K |