| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1509 |
Name | CTSD |
Synonymous | cathepsin D;CTSD;cathepsin D |
Definition | ceroid-lipofuscinosis, neuronal 10|epididymis secretory sperm binding protein Li 130P|lysosomal aspartyl peptidase|lysosomal aspartyl protease |
Position | 11p15.5 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | CTSD(h) --> cathepsin-D(h) (expression). | cathepsin-D(h) --/ Trx1(h) (decrease of abundance) | cathepsin-D(h) --> cathepsinD-p32(h) + protein remnants (cleavage) | cathepsin-D(h) --> cathepsin-D(h) (translocation) | CTSD(h) --> cathepsin-D(h) (expression). | estradiol --> cathepsin-D(h) (increase of abundance) | NAG-7(h) --/ cathepsin-D(h) (decrease of abundance) | cathepsin-D(h) --> cathepsin-D(h) (translocation) | prolactin(h) --cathepsin-D(h)--> prolactin-p17(h) + protein remnants (cleavage) | prolactin(h) --cathepsin-D(h)--> prolactin-p15(h) + protein remnants (cleavage) | prolactin(h) --cathepsin-D(h)--> prolactin-p11(h) + protein remnants (cleavage) | prolactin(h) --cathepsin-D(h)--> prolactin-p8(h) + protein remnants (cleavage) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 134 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 263 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 1741298 - 1743298 | Agilent_014791 |
chr11 |
Promoter: 1741298 - 1743298 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 1741298 - 1743298 | GSE27584 |
chr11 |
Promoter: 1741298 - 1743298 | Agilent_014791_44K |