Entrez Gene

Basic Information
Gene ID	93663
Name	ARHGAP18
Synonymous	Rho GTPase activating protein 18;ARHGAP18;Rho GTPase activating protein 18
Definition	rho GTPase-activating protein 18\|rho-type GTPase-activating protein 18
Position	6q22.33
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.983C>T; p.A328V; 6:129616273-129616273	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.247G>A; p.E83K; 6:129641885-129641885	skin; extremity	malignant_melanoma	Substitution - Missense
c.1882G>A; p.E628K; 6:129580088-129580088	skin	malignant_melanoma	Substitution - Missense
c.488delA; p.N163fs*55; 6:129638458-129638458	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.488delA; p.N163fs*55; 6:129638458-129638458	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1602G>T; p.R534S; 6:129599327-129599327	skin	malignant_melanoma	Substitution - Missense
c.540A>C; p.E180D; 6:129638406-129638406	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.726T>C; p.N242N; 6:129629413-129629413	breast	carcinoma	Substitution - coding silent
c.1562T>G; p.L521R; 6:129600652-129600652	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1877delT; p.L626fs*19; 6:129580093-129580093	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1957A>C; p.N653H; 6:129578548-129578548	skin	malignant_melanoma	Substitution - Missense
c.1152T>G; p.F384L; 6:129608023-129608023	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1418T>G; p.M473R; 6:129600796-129600796	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.188G>A; p.R63Q; 6:129641944-129641944	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1258C>T; p.L420F; 6:129607917-129607917	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1332C>G; p.I444M; 6:129605910-129605910	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.202G>A; p.D68N; 6:129641930-129641930	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1103G>C; p.G368A; 6:129611552-129611552	NS	NS	Substitution - Missense
c.592G>T; p.E198*; 6:129634066-129634066	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.375G>A; p.E125E; 6:129638571-129638571	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.229G>A; p.D77N; 6:129641903-129641903	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.204T>C; p.D68D; 6:129641928-129641928	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1452G>A; p.P484P; 6:129600762-129600762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.601T>C; p.Y201H; 6:129634057-129634057	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.601T>C; p.Y201H; 6:129634057-129634057	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1903G>A; p.E635K; 6:129578602-129578602	skin	malignant_melanoma	Substitution - Missense
c.1602G>A; p.R534R; 6:129599327-129599327	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.529C>A; p.Q177K; 6:129638417-129638417	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.618C>T; p.D206D; 6:129629521-129629521	liver	carcinoma	Substitution - coding silent
c.1562T>C; p.L521P; 6:129600652-129600652	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1488C>T; p.S496S; 6:129600726-129600726	skin	malignant_melanoma	Substitution - coding silent
c.618C>T; p.D206D; 6:129629521-129629521	liver	carcinoma	Substitution - coding silent
c.182T>C; p.F61S; 6:129641950-129641950	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.492delA; p.K164fs*54; 6:129638454-129638454	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.1067G>C; p.R356T; 6:129611588-129611588	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.550A>G; p.T184A; 6:129638396-129638396	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.316+2T>C; p.?; 6:129641814-129641814	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1202G>A; p.S401N; 6:129607973-129607973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1558A>C; p.K520Q; 6:129600656-129600656	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.691A>G; p.N231D; 6:129629448-129629448	skin	malignant_melanoma	Substitution - Missense
c.170A>G; p.E57G; 6:129641962-129641962	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1198G>C; p.A400P; 6:129607977-129607977	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1733T>C; p.V578A; 6:129584093-129584093	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.643G>A; p.E215K; 6:129629496-129629496	skin	malignant_melanoma	Substitution - Missense
c.697G>T; p.E233*; 6:129629442-129629442	liver	carcinoma	Substitution - Nonsense
c.697G>T; p.E233*; 6:129629442-129629442	liver	carcinoma	Substitution - Nonsense
c.556C>G; p.P186A; 6:129634102-129634102	breast	carcinoma	Substitution - Missense
c.570A>C; p.E190D; 6:129634088-129634088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1208T>C; p.L403P; 6:129607967-129607967	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.940A>C; p.I314L; 6:129618699-129618699	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1647G>T; p.K549N; 6:129599282-129599282	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.328G>A; p.E110K; 6:129638618-129638618	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1906C>T; p.R636C; 6:129578599-129578599	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.115C>T; p.R39C; 6:129642017-129642017	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.388C>A; p.P130T; 6:129638558-129638558	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>T; p.D318Y; 6:129618687-129618687	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1091T>G; p.L364*; 6:129611564-129611564	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.29T>C; p.V10A; 6:129710108-129710108	breast	carcinoma	Substitution - Missense
c.503T>G; p.I168S; 6:129638443-129638443	skin	malignant_melanoma	Substitution - Missense
c.1698T>C; p.D566D; 6:129599231-129599231	prostate	carcinoma	Substitution - coding silent
c.1577C>T; p.P526L; 6:129599352-129599352	thyroid	carcinoma	Substitution - Missense
c.10C>T; p.L4F; 6:129710127-129710127	prostate	carcinoma	Substitution - Missense
c.970G>A; p.V324I; 6:129616286-129616286	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1734G>T; p.V578V; 6:129584092-129584092	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1807G>T; p.D603Y; 6:129584019-129584019	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1428G>C; p.M476I; 6:129600786-129600786	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1428G>C; p.M476I; 6:129600786-129600786	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1713+1G>C; p.?; 6:129599215-129599215	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Unknown
c.346G>A; p.E116K; 6:129638600-129638600	breast	carcinoma	Substitution - Missense
c.651G>T; p.L217L; 6:129629488-129629488	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.490A>G; p.K164E; 6:129638456-129638456	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.528T>A; p.A176A; 6:129638418-129638418	central_nervous_system; brain	glioma	Substitution - coding silent
c.1399A>C; p.N467H; 6:129600815-129600815	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1060G>A; p.E354K; 6:129611595-129611595	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.32T>C; p.V11A; 6:129710105-129710105	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.102A>C; p.E34D; 6:129710035-129710035	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1747G>A; p.A583T; 6:129584079-129584079	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1734G>C; p.V578V; 6:129584092-129584092	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.837C>T; p.L279L; 6:129618802-129618802	breast	carcinoma	Substitution - coding silent
c.1135G>T; p.E379*; 6:129608040-129608040	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.197C>T; p.S66F; 6:129641935-129641935	skin	malignant_melanoma	Substitution - Missense
c.787-1G>T; p.?; 6:129618853-129618853	skin; hand	malignant_melanoma	Unknown
c.1693C>T; p.Q565*; 6:129599236-129599236	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1022G>A; p.R341Q; 6:129616234-129616234	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.289G>T; p.E97*; 6:129641843-129641843	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1928A>C; p.Y643S; 6:129578577-129578577	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1928A>C; p.Y643S; 6:129578577-129578577	urinary_tract; bladder	carcinoma	Substitution - Missense
c.922C>T; p.Q308*; 6:129618717-129618717	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.67A>G; p.T23A; 6:129710070-129710070	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1126C>A; p.L376I; 6:129608049-129608049	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1126C>A; p.L376I; 6:129608049-129608049	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1316T>G; p.L439W; 6:129605926-129605926	skin	malignant_melanoma	Substitution - Missense
c.116G>A; p.R39H; 6:129642016-129642016	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1919A>T; p.D640V; 6:129578586-129578586	pancreas	carcinoma	Substitution - Missense
c.1919A>T; p.D640V; 6:129578586-129578586	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1827C>T; p.L609L; 6:129583999-129583999	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.731_734delAAGA; p.K244fs*40; 6:129629405-129629408	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Deletion - Frameshift
c.1027C>T; p.P343S; 6:129616229-129616229	breast	carcinoma	Substitution - Missense
c.252C>T; p.N84N; 6:129641880-129641880	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]