Entrez Gene

Basic Information
Gene ID	8900
Name	CCNA1
Synonymous	cyclin A1;CCNA1;cyclin A1
Definition	cyclin-A1
Position	13q12.3-q13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.44T>C; p.I15T; 13:36432665-36432665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.944C>A; p.T315N; 13:36440029-36440029	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1132C>T; p.P378S; 13:36441151-36441151	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.462G>A; p.E154E; 13:36437793-36437793	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.369T>C; p.P123P; 13:36437700-36437700	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.18C>A; p.P6P; 13:36432639-36432639	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.1045C>T; p.L349F; 13:36440130-36440130	skin	malignant_melanoma	Substitution - Missense
c.1279C>T; p.H427Y; 13:36442237-36442237	skin	malignant_melanoma	Substitution - Missense
c.1355G>A; p.C452Y; 13:36442622-36442622	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.814C>A; p.L272M; 13:36438788-36438788	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1089delC; p.L364fs*5; 13:36440174-36440174	liver	carcinoma	Deletion - Frameshift
c.108G>A; p.Q36Q; 13:36432729-36432729	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.781C>T; p.R261*; 13:36438755-36438755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1015C>A; p.L339M; 13:36440100-36440100	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1354T>C; p.C452R; 13:36442621-36442621	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1354T>C; p.C452R; 13:36442621-36442621	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.180C>T; p.A60A; 13:36433104-36433104	skin	malignant_melanoma	Substitution - coding silent
c.150C>T; p.P50P; 13:36433074-36433074	skin; arm	malignant_melanoma	Substitution - coding silent
c.207C>T; p.L69L; 13:36433131-36433131	liver	carcinoma	Substitution - coding silent
c.755T>G; p.V252G; 13:36438729-36438729	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755T>G; p.V252G; 13:36438729-36438729	thyroid	other; neoplasm	Substitution - Missense
c.755T>G; p.V252G; 13:36438729-36438729	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755T>G; p.V252G; 13:36438729-36438729	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755T>G; p.V252G; 13:36438729-36438729	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755T>G; p.V252G; 13:36438729-36438729	thyroid	other; neoplasm	Substitution - Missense
c.755T>G; p.V252G; 13:36438729-36438729	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.207C>T; p.L69L; 13:36433131-36433131	liver	carcinoma	Substitution - coding silent
c.755T>G; p.V252G; 13:36438729-36438729	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755T>G; p.V252G; 13:36438729-36438729	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.367C>T; p.P123S; 13:36437698-36437698	skin	malignant_melanoma	Substitution - Missense
c.649C>A; p.Q217K; 13:36438171-36438171	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.413A>G; p.Y138C; 13:36437744-36437744	liver	carcinoma	Substitution - Missense
c.433G>A; p.G145R; 13:36437764-36437764	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.127G>A; p.E43K; 13:36433051-36433051	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1202A>G; p.K401R; 13:36441221-36441221	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.325G>C; p.G109R; 13:36437656-36437656	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.969A>G; p.Q323Q; 13:36440054-36440054	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.357G>A; p.K119K; 13:36437688-36437688	skin	malignant_melanoma	Substitution - coding silent
c.700A>C; p.K234Q; 13:36438674-36438674	skin	malignant_melanoma	Substitution - Missense
c.357G>A; p.K119K; 13:36437688-36437688	skin	malignant_melanoma	Substitution - coding silent
c.909A>G; p.I303M; 13:36439994-36439994	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.384A>C; p.Q128H; 13:36437715-36437715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.330A>G; p.S110S; 13:36437661-36437661	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.301_309delATCACAAGA; p.T102_I104delTRI; 13:36437632-36437640	breast	carcinoma	Deletion - In frame
c.726C>T; p.G242G; 13:36438700-36438700	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.730C>T; p.R244C; 13:36438704-36438704	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.418G>A; p.D140N; 13:36437749-36437749	skin	malignant_melanoma	Substitution - Missense
c.418G>A; p.D140N; 13:36437749-36437749	skin	malignant_melanoma	Substitution - Missense
c.102C>T; p.V34V; 13:36432723-36432723	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.764G>T; p.G255V; 13:36438738-36438738	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1129G>C; p.D377H; 13:36441148-36441148	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.463G>A; p.G155R; 13:36437794-36437794	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.350C>T; p.A117V; 13:36437681-36437681	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.432delG; p.D146fs*19; 13:36437763-36437763	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1252G>A; p.E418K; 13:36442210-36442210	skin; trunk	malignant_melanoma	Substitution - Missense
c.188C>T; p.P63L; 13:36433112-36433112	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.332A>G; p.E111G; 13:36437663-36437663	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1385T>G; p.L462R; 13:36442652-36442652	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.421G>T; p.E141*; 13:36437752-36437752	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.715A>C; p.I239L; 13:36438689-36438689	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.253G>T; p.G85W; 13:36433177-36433177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.344C>A; p.P115H; 13:36437675-36437675	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.550C>T; p.P184S; 13:36438072-36438072	skin	malignant_melanoma	Substitution - Missense
c.1080G>T; p.R360S; 13:36440165-36440165	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1173delT; p.C393fs*7; 13:36441192-36441192	thyroid	carcinoma; anaplastic_carcinoma	Deletion - Frameshift
c.1210T>C; p.W404R; 13:36441229-36441229	central_nervous_system; brain	glioma	Substitution - Missense
c.913C>T; p.P305S; 13:36439998-36439998	skin	malignant_melanoma	Substitution - Missense
c.29A>G; p.Y10C; 13:36432650-36432650	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.946G>A; p.D316N; 13:36440031-36440031	skin	malignant_melanoma	Substitution - Missense
c.946G>A; p.D316N; 13:36440031-36440031	skin	malignant_melanoma	Substitution - Missense
c.1075G>A; p.V359I; 13:36440160-36440160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1075G>A; p.V359I; 13:36440160-36440160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.149C>T; p.P50L; 13:36433073-36433073	skin; arm	malignant_melanoma	Substitution - Missense
c.1314G>T; p.Q438H; 13:36442272-36442272	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1038G>A; p.Q346Q; 13:36440123-36440123	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.784G>T; p.A262S; 13:36438758-36438758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.945C>T; p.T315T; 13:36440030-36440030	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.945C>T; p.T315T; 13:36440030-36440030	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1065A>C; p.Q355H; 13:36440150-36440150	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.732C>T; p.R244R; 13:36438706-36438706	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.337G>T; p.A113S; 13:36437668-36437668	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.298-7T>G; p.?; 13:36437622-36437622	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.949G>A; p.D317N; 13:36440034-36440034	skin	malignant_melanoma	Substitution - Missense
c.321T>C; p.Y107Y; 13:36437652-36437652	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.238C>T; p.Q80*; 13:36433162-36433162	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.464_465GG>AA; p.G155E; 13:36437795-36437796	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.928G>A; p.E310K; 13:36440013-36440013	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.417G>A; p.M139I; 13:36437748-36437748	skin	malignant_melanoma	Substitution - Missense
c.322T>A; p.S108T; 13:36437653-36437653	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.589G>T; p.D197Y; 13:36438111-36438111	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1156C>G; p.L386V; 13:36441175-36441175	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1287G>A; p.A429A; 13:36442245-36442245	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1287G>A; p.A429A; 13:36442245-36442245	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1287G>A; p.A429A; 13:36442245-36442245	stomach	adenocarcinoma	Substitution - coding silent
c.305C>G; p.T102R; 13:36437636-36437636	skin	malignant_melanoma	Substitution - Missense
c.1102G>A; p.V368I; 13:36441121-36441121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.64T>A; p.Y22N; 13:36432685-36432685	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.274C>T; p.Q92*; 13:36433198-36433198	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.525C>T; p.F175F; 13:36437856-36437856	skin	malignant_melanoma	Substitution - coding silent
c.440G>A; p.R147K; 13:36437771-36437771	skin	malignant_melanoma	Substitution - Missense
c.956_957delAC; p.T320fs*18; 13:36440041-36440042	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1307G>T; p.R436L; 13:36442265-36442265	liver	carcinoma	Substitution - Missense
c.1307G>T; p.R436L; 13:36442265-36442265	liver	carcinoma	Substitution - Missense
c.108+3A>T; p.?; 13:36432732-36432732	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.1217A>C; p.E406A; 13:36442175-36442175	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.181C>T; p.R61*; 13:36433105-36433105	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.719C>T; p.T240M; 13:36438693-36438693	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1173T>A; p.A391A; 13:36441192-36441192	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1173T>A; p.A391A; 13:36441192-36441192	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1061G>A; p.R354Q; 13:36440146-36440146	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1061G>A; p.R354Q; 13:36440146-36440146	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1039T>C; p.F347L; 13:36440124-36440124	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.906G>A; p.E302E; 13:36439991-36439991	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1286C>T; p.A429V; 13:36442244-36442244	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1387C>T; p.L463F; 13:36442654-36442654	skin	malignant_melanoma	Substitution - Missense
c.1286C>T; p.A429V; 13:36442244-36442244	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.981G>T; p.M327I; 13:36440066-36440066	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1090C>T; p.L364L; 13:36440175-36440175	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.640G>T; p.E214*; 13:36438162-36438162	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1363C>T; p.L455F; 13:36442630-36442630	skin	malignant_melanoma	Substitution - Missense
c.234C>T; p.P78P; 13:36433158-36433158	skin	malignant_melanoma	Substitution - coding silent
c.731G>A; p.R244H; 13:36438705-36438705	large_intestine; colon	NS	Substitution - Missense
c.1312C>A; p.Q438K; 13:36442270-36442270	skin	malignant_melanoma	Substitution - Missense
c.731G>A; p.R244H; 13:36438705-36438705	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.809A>G; p.N270S; 13:36438783-36438783	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.901G>A; p.E301K; 13:36439986-36439986	skin	malignant_melanoma	Substitution - Missense
c.809A>G; p.N270S; 13:36438783-36438783	urinary_tract; bladder	carcinoma	Substitution - Missense
c.197G>A; p.C66Y; 13:36433121-36433121	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.785C>T; p.A262V; 13:36438759-36438759	liver	carcinoma	Substitution - Missense
c.785C>T; p.A262V; 13:36438759-36438759	liver	carcinoma	Substitution - Missense
c.1276C>A; p.L426I; 13:36442234-36442234	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1368G>A; p.M456I; 13:36442635-36442635	skin	malignant_melanoma	Substitution - Missense
c.855A>G; p.K285K; 13:36438829-36438829	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.608C>A; p.T203K; 13:36438130-36438130	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1099-2A>T; p.?; 13:36441116-36441116	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1349A>G; p.Y450C; 13:36442616-36442616	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1099-2A>T; p.?; 13:36441116-36441116	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1099-2A>T; p.?; 13:36441116-36441116	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.366_367CC>TT; p.P123>S; 13:36437697-36437698	lung	carcinoma; non_small_cell_carcinoma	Complex - compound substitution
c.259C>T; p.L87L; 13:36433183-36433183	large_intestine; colon	NS	Substitution - coding silent
c.377G>C; p.G126A; 13:36437708-36437708	liver	carcinoma	Substitution - Missense
c.377G>C; p.G126A; 13:36437708-36437708	liver	carcinoma	Substitution - Missense
c.761T>G; p.V254G; 13:36438735-36438735	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.761T>G; p.V254G; 13:36438735-36438735	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.76G>A; p.E26K; 13:36432697-36432697	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.76G>A; p.E26K; 13:36432697-36432697	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.281G>T; p.R94M; 13:36433205-36433205	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.958A>G; p.T320A; 13:36440043-36440043	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.821G>T; p.R274M; 13:36438795-36438795	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.41T>G; p.F14C; 13:36432662-36432662	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.778C>A; p.L260I; 13:36438752-36438752	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.217C>A; p.P73T; 13:36433141-36433141	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.559G>A; p.V187I; 13:36438081-36438081	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1218A>G; p.E406E; 13:36442176-36442176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.304A>C; p.T102P; 13:36437635-36437635	pleura	pulmonary_blastoma	Substitution - Missense
c.790A>G; p.T264A; 13:36438764-36438764	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1021G>A; p.V341I; 13:36440106-36440106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.108G>T; p.Q36H; 13:36432729-36432729	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.366C>T; p.L122L; 13:36437697-36437697	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.366C>T; p.L122L; 13:36437697-36437697	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.366C>T; p.L122L; 13:36437697-36437697	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1117C>A; p.L373I; 13:36441136-36441136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.982G>T; p.E328*; 13:36440067-36440067	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.38C>T; p.S13F; 13:36432659-36432659	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.574C>A; p.L192I; 13:36438096-36438096	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.758A>G; p.E253G; 13:36438732-36438732	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1244C>A; p.S415*; 13:36442202-36442202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.368C>T; p.P123L; 13:36437699-36437699	skin	malignant_melanoma	Substitution - Missense
c.701A>C; p.K234T; 13:36438675-36438675	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.507C>T; p.L169L; 13:36437838-36437838	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.232C>T; p.P78S; 13:36433156-36433156	liver	carcinoma	Substitution - Missense
c.514G>C; p.D172H; 13:36437845-36437845	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.514G>C; p.D172H; 13:36437845-36437845	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1079G>A; p.R360K; 13:36440164-36440164	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.232C>T; p.P78S; 13:36433156-36433156	liver	carcinoma	Substitution - Missense
c.1220C>A; p.T407N; 13:36442178-36442178	breast	carcinoma	Substitution - Missense
c.793C>A; p.L265M; 13:36438767-36438767	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.700A>T; p.K234*; 13:36438674-36438674	thyroid	other; neoplasm	Substitution - Nonsense
c.965G>A; p.R322Q; 13:36440050-36440050	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.381C>T; p.V127V; 13:36437712-36437712	urinary_tract; bladder	carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]