Entrez Gene

Basic Information
Gene ID	84678
Name	KDM2B
Synonymous	lysine (K)-specific demethylase 2B;KDM2B;lysine (K)-specific demethylase 2B
Definition	CXXC-type zinc finger protein 2\|F-box and leucine-rich repeat protein 10\|F-box protein FBL10\|F-box/LRR-repeat protein 10\|JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein\|[Histone-H3]-lysine-36 demethylase 1B\|jmjC domain-containing
Position	12q24.31
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2251T>C; p.S751P; 12:121441184-121441184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2251T>C; p.S751P; 12:121441184-121441184	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1275G>A; p.P425P; 12:121444105-121444105	skin	malignant_melanoma	Substitution - coding silent
c.2777C>T; p.S926F; 12:121430439-121430439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1350G>T; p.E450D; 12:121444030-121444030	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2381T>C; p.V794A; 12:121440962-121440962	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.967A>T; p.M323L; 12:121445328-121445328	liver	carcinoma	Substitution - Missense
c.967A>T; p.M323L; 12:121445328-121445328	liver	carcinoma	Substitution - Missense
c.1711_1713delAAG; p.K571delK; 12:121442645-121442647	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Deletion - In frame
c.1150G>T; p.G384C; 12:121444230-121444230	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1775A>G; p.E592G; 12:121442583-121442583	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1933_1934insC; p.R645fs*48; 12:121442424-121442425	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.898G>A; p.V300M; 12:121445397-121445397	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>T; p.G68G; 12:121509927-121509927	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1273C>T; p.P425S; 12:121444107-121444107	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2063G>T; p.S688I; 12:121442295-121442295	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2304C>A; p.L768L; 12:121441131-121441131	breast	carcinoma	Substitution - coding silent
c.2361G>T; p.L787L; 12:121441074-121441074	breast	carcinoma	Substitution - coding silent
c.1933delC; p.R645fs*37; 12:121442425-121442425	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1755G>C; p.L585L; 12:121442603-121442603	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2362C>A; p.P788T; 12:121441073-121441073	liver	carcinoma	Substitution - Missense
c.2070_2071insC; p.D692fs*1; 12:121442287-121442288	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.2860A>G; p.I954V; 12:121430356-121430356	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2362C>A; p.P788T; 12:121441073-121441073	liver	carcinoma	Substitution - Missense
c.2098G>A; p.A700T; 12:121442260-121442260	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.450G>T; p.E150D; 12:121509681-121509681	prostate	carcinoma	Substitution - Missense
c.933C>T; p.D311D; 12:121445362-121445362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.745C>T; p.R249W; 12:121453251-121453251	soft_tissue; fibrous_tissue_and_uncertain_o	synovial_sarcoma	Substitution - Missense
c.2487G>A; p.Q829Q; 12:121440856-121440856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1861G>A; p.E621K; 12:121442497-121442497	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1273C>A; p.P425T; 12:121444107-121444107	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_associated_with_MDS	Substitution - Missense
c.321C>T; p.F107F; 12:121509810-121509810	skin	malignant_melanoma	Substitution - coding silent
c.1351C>T; p.L451L; 12:121444029-121444029	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.831C>A; p.G277G; 12:121453165-121453165	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.199G>T; p.E67*; 12:121509932-121509932	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1639G>A; p.D547N; 12:121442719-121442719	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2011C>T; p.P671S; 12:121442347-121442347	skin	malignant_melanoma	Substitution - Missense
c.1335C>T; p.Y445Y; 12:121444045-121444045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1335C>T; p.Y445Y; 12:121444045-121444045	breast	carcinoma	Substitution - coding silent
c.418G>C; p.E140Q; 12:121509713-121509713	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2016C>T; p.P672P; 12:121442342-121442342	skin	malignant_melanoma	Substitution - coding silent
c.2857T>C; p.F953L; 12:121430359-121430359	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.409C>T; p.P137S; 12:121509722-121509722	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.196G>A; p.E66K; 12:121509935-121509935	breast	carcinoma	Substitution - Missense
c.1027G>T; p.E343*; 12:121444530-121444530	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.478G>A; p.V160M; 12:121509653-121509653	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2893C>A; p.Q965K; 12:121430323-121430323	breast	carcinoma	Substitution - Missense
c.1520delA; p.K507fs*66; 12:121442993-121442993	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1704G>A; p.E568E; 12:121442654-121442654	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.210C>T; p.G70G; 12:121509921-121509921	ovary	other; neoplasm	Substitution - coding silent
c.1114C>T; p.R372C; 12:121444266-121444266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.102G>A; p.R34R; 12:121510029-121510029	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1114C>T; p.R372C; 12:121444266-121444266	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1114C>T; p.R372C; 12:121444266-121444266	bone; fibula	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.765C>T; p.C255C; 12:121453231-121453231	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.72G>C; p.Q24H; 12:121513295-121513295	pancreas	carcinoma	Substitution - Missense
c.2131G>A; p.A711T; 12:121442227-121442227	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.619C>T; p.P207S; 12:121494611-121494611	skin	malignant_melanoma	Substitution - Missense
c.155A>T; p.E52V; 12:121509976-121509976	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2461T>A; p.W821R; 12:121440882-121440882	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.713C>T; p.A238V; 12:121453283-121453283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2490G>A; p.M830I; 12:121440853-121440853	pancreas	carcinoma	Substitution - Missense
c.393G>T; p.K131N; 12:121509738-121509738	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1877C>T; p.P626L; 12:121442481-121442481	skin	malignant_melanoma	Substitution - Missense
c.1313A>G; p.H438R; 12:121444067-121444067	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1313A>G; p.H438R; 12:121444067-121444067	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1387_1388insC; p.G465fs*38; 12:121443774-121443775	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Insertion - Frameshift
c.1703_1705delAGA; p.K571delK; 12:121442653-121442655	ovary	carcinoma	Deletion - In frame
c.1696C>T; p.P566S; 12:121442662-121442662	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.208G>T; p.G70C; 12:121509923-121509923	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2736C>A; p.I912I; 12:121439867-121439867	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2714C>A; p.T905N; 12:121439889-121439889	thyroid	carcinoma	Substitution - Missense
c.329G>A; p.R110K; 12:121509802-121509802	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.831C>G; p.G277G; 12:121453165-121453165	liver	carcinoma	Substitution - coding silent
c.2411C>T; p.S804L; 12:121440932-121440932	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2562C>T; p.I854I; 12:121440041-121440041	skin	malignant_melanoma	Substitution - coding silent
c.2562C>T; p.I854I; 12:121440041-121440041	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.698C>T; p.A233V; 12:121453298-121453298	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1549C>T; p.R517C; 12:121442809-121442809	oesophagus	carcinoma	Substitution - Missense
c.2412G>A; p.S804S; 12:121440931-121440931	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1903C>T; p.R635C; 12:121442455-121442455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>A; p.A95A; 12:121509846-121509846	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.525_526GG>AA; p.G176S; 12:121509605-121509606	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2396C>T; p.S799L; 12:121440947-121440947	pancreas	carcinoma	Substitution - Missense
c.742C>G; p.R248G; 12:121453254-121453254	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.400A>C; p.T134P; 12:121509731-121509731	pancreas	carcinoma	Substitution - Missense
c.806G>A; p.C269Y; 12:121453190-121453190	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1585A>G; p.K529E; 12:121442773-121442773	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.521C>T; p.P174L; 12:121509610-121509610	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.788G>A; p.C263Y; 12:121453208-121453208	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.788G>A; p.C263Y; 12:121453208-121453208	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1767G>A; p.L589L; 12:121442591-121442591	skin	malignant_melanoma	Substitution - coding silent
c.1575C>T; p.L525L; 12:121442783-121442783	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1841C>T; p.S614L; 12:121442517-121442517	skin	malignant_melanoma	Substitution - Missense
c.1235C>T; p.A412V; 12:121444145-121444145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1641C>T; p.D547D; 12:121442717-121442717	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1376C>T; p.S459L; 12:121443786-121443786	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.A220T; 12:121453338-121453338	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.2526A>G; p.P842P; 12:121440817-121440817	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2746G>A; p.D916N; 12:121439857-121439857	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1943G>A; p.R648Q; 12:121442415-121442415	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2785A>G; p.K929E; 12:121430431-121430431	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2140A>T; p.S714C; 12:121442218-121442218	liver	carcinoma	Substitution - Missense
c.980G>C; p.C327S; 12:121445315-121445315	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2391C>T; p.G797G; 12:121440952-121440952	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1273_1274CC>AG; p.P425>?; 12:121444106-121444107	large_intestine; caecum	carcinoma; adenocarcinoma	Complex
c.2491C>T; p.R831W; 12:121440852-121440852	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1624_1625insCC; p.K542fs*32; 12:121442733-121442734	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.317G>A; p.R106Q; 12:121509814-121509814	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1810C>A; p.L604M; 12:121442548-121442548	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.752G>A; p.R251Q; 12:121453244-121453244	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.752G>A; p.R251Q; 12:121453244-121453244	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2672C>T; p.T891I; 12:121439931-121439931	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_associated_with_MDS	Substitution - Missense
c.2865C>A; p.A955A; 12:121430351-121430351	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.365C>G; p.S122C; 12:121509766-121509766	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1998A>G; p.P666P; 12:121442360-121442360	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.1831C>T; p.P611S; 12:121442527-121442527	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1343C>T; p.P448L; 12:121444037-121444037	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2107G>A; p.V703I; 12:121442251-121442251	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2444G>A; p.R815Q; 12:121440899-121440899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2196C>T; p.N732N; 12:121442162-121442162	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2643G>T; p.K881N; 12:121439960-121439960	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.2919delA; p.K973fs*2; 12:121430297-121430297	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2609G>A; p.R870Q; 12:121439994-121439994	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2587G>T; p.D863Y; 12:121440016-121440016	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.814A>G; p.M272V; 12:121453182-121453182	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1724G>A; p.R575H; 12:121442634-121442634	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2527G>C; p.G843R; 12:121440816-121440816	ovary	other; neoplasm	Substitution - Missense
c.609C>T; p.I203I; 12:121494621-121494621	skin	malignant_melanoma	Substitution - coding silent
c.2158G>C; p.D720H; 12:121442200-121442200	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1666G>A; p.A556T; 12:121442692-121442692	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1666G>A; p.A556T; 12:121442692-121442692	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1666G>A; p.A556T; 12:121442692-121442692	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1080_1081GT>AG; p.C361G; 12:121444476-121444477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.746G>A; p.R249Q; 12:121453250-121453250	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.401C>T; p.T134I; 12:121509730-121509730	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.2300C>T; p.S767F; 12:121441135-121441135	skin	malignant_melanoma	Substitution - Missense
c.2300C>T; p.S767F; 12:121441135-121441135	skin	malignant_melanoma	Substitution - Missense
c.1292G>A; p.R431H; 12:121444088-121444088	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2527+2T>G; p.?; 12:121440814-121440814	skin	malignant_melanoma	Unknown
c.39G>T; p.V13V; 12:121513328-121513328	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1309G>A; p.V437M; 12:121444071-121444071	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1623C>T; p.P541P; 12:121442735-121442735	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.468G>A; p.L156L; 12:121509663-121509663	skin	malignant_melanoma	Substitution - coding silent
c.2170_2171delTG; p.C724fs*14; 12:121442187-121442188	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1161C>G; p.L387L; 12:121444219-121444219	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2288G>A; p.R763Q; 12:121441147-121441147	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.431A>G; p.K144R; 12:121509700-121509700	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.2400G>A; p.W800*; 12:121440943-121440943	bone; scapula	chondrosarcoma	Substitution - Nonsense
c.1327C>T; p.R443W; 12:121444053-121444053	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.596C>T; p.P199L; 12:121494634-121494634	skin	malignant_melanoma	Substitution - Missense
c.839G>A; p.R280H; 12:121453157-121453157	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2228G>A; p.R743H; 12:121441207-121441207	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.839G>A; p.R280H; 12:121453157-121453157	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2584C>A; p.L862M; 12:121440019-121440019	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1557G>A; p.A519A; 12:121442801-121442801	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1576C>T; p.R526W; 12:121442782-121442782	breast	carcinoma	Substitution - Missense
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1066T>C; p.W356R; 12:121444491-121444491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.2805delT; p.H936fs*4; 12:121430411-121430411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1522C>T; p.R508W; 12:121442836-121442836	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2305G>T; p.D769Y; 12:121441130-121441130	ovary	carcinoma	Substitution - Missense
c.345G>A; p.E115E; 12:121509786-121509786	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]