Entrez Gene

Basic Information
Gene ID	7316
Name	UBC
Synonymous	ubiquitin C;UBC;ubiquitin C
Definition	polyubiquitin-C
Position	12q24.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1990C>A; p.L664M; 12:124911782-124911782	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1117C>A; p.L373M; 12:124912655-124912655	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.508G>A; p.E170K; 12:124913264-124913264	liver	carcinoma	Substitution - Missense
c.60T>C; p.S20S; 12:124913712-124913712	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.307A>T; p.K103*; 12:124913465-124913465	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.949A>G; p.I317V; 12:124912823-124912823	thyroid	carcinoma	Substitution - Missense
c.1082C>G; p.S361C; 12:124912690-124912690	breast	carcinoma	Substitution - Missense
c.1849A>C; p.T617P; 12:124911923-124911923	breast	carcinoma	Substitution - Missense
c.195C>T; p.S65S; 12:124913577-124913577	thyroid	other; neoplasm	Substitution - coding silent
c.1049C>T; p.A350V; 12:124912723-124912723	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1049C>T; p.A350V; 12:124912723-124912723	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.335T>C; p.I112T; 12:124913437-124913437	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.982G>C; p.E328Q; 12:124912790-124912790	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.982G>C; p.E328Q; 12:124912790-124912790	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1587T>C; p.L529L; 12:124912185-124912185	breast	carcinoma	Substitution - coding silent
c.1544A>T; p.Y515F; 12:124912228-124912228	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.274G>T; p.E92*; 12:124913498-124913498	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.124A>C; p.R42R; 12:124913648-124913648	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.750T>C; p.T250T; 12:124913022-124913022	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2052_2053insG; p.V685fs*>2; 12:124911719-124911720	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.2027A>G; p.H676R; 12:124911745-124911745	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.849C>T; p.T283T; 12:124912923-124912923	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.366C>T; p.A122A; 12:124913406-124913406	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1455G>A; p.K485K; 12:124912317-124912317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.754G>C; p.E252Q; 12:124913018-124913018	breast	carcinoma	Substitution - Missense
c.1665T>C; p.I555I; 12:124912107-124912107	thyroid	other; neoplasm	Substitution - coding silent
c.491C>T; p.T164I; 12:124913281-124913281	skin	malignant_melanoma	Substitution - Missense
c.634A>G; p.N212D; 12:124913138-124913138	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.634A>G; p.N212D; 12:124913138-124913138	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1953G>A; p.L651L; 12:124911819-124911819	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.243G>A; p.V81V; 12:124913529-124913529	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2003_2005delACA; p.N668delN; 12:124911767-124911769	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.9C>A; p.I3I; 12:124913763-124913763	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.873A>G; p.K291K; 12:124912899-124912899	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1272C>A; p.I424I; 12:124912500-124912500	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.154G>A; p.D52N; 12:124913618-124913618	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1255G>T; p.D419Y; 12:124912517-124912517	breast	carcinoma	Substitution - Missense
c.411C>G; p.I137M; 12:124913361-124913361	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.700A>G; p.K234E; 12:124913072-124913072	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1165A>G; p.T389A; 12:124912607-124912607	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1941T>C; p.D647D; 12:124911831-124911831	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.46G>C; p.E16Q; 12:124913726-124913726	oesophagus	carcinoma	Substitution - Missense
c.622C>A; p.L208M; 12:124913150-124913150	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>A; p.L208M; 12:124913150-124913150	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>A; p.L208M; 12:124913150-124913150	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>A; p.L208M; 12:124913150-124913150	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2029T>C; p.L677L; 12:124911743-124911743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2029T>C; p.L677L; 12:124911743-124911743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.655T>C; p.L219L; 12:124913117-124913117	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.969G>C; p.P323P; 12:124912803-124912803	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1257C>T; p.D419D; 12:124912515-124912515	breast	carcinoma	Substitution - coding silent
c.783G>T; p.K261N; 12:124912989-124912989	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1257C>T; p.D419D; 12:124912515-124912515	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1257C>T; p.D419D; 12:124912515-124912515	thyroid	other; neoplasm	Substitution - coding silent
c.2006T>A; p.I669N; 12:124911766-124911766	stomach	adenocarcinoma	Substitution - Missense
c.61G>A; p.D21N; 12:124913711-124913711	urinary_tract; bladder	carcinoma	Substitution - Missense
c.61G>A; p.D21N; 12:124913711-124913711	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2051_2052insG; p.V685fs*>2; 12:124911720-124911721	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2051_2052insG; p.V685fs*>2; 12:124911720-124911721	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.416_419delAAGA; p.K139fs*18; 12:124913353-124913356	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1157A>G; p.K386R; 12:124912615-124912615	breast	carcinoma	Substitution - Missense
c.1210G>C; p.E404Q; 12:124912562-124912562	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1477C>A; p.P493T; 12:124912295-124912295	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1918G>T; p.D640Y; 12:124911854-124911854	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.958G>T; p.E320*; 12:124912814-124912814	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1683G>T; p.K561N; 12:124912089-124912089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1925_1928delAAGG; p.E642fs*9; 12:124911844-124911847	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.730G>C; p.E244Q; 12:124913042-124913042	breast	carcinoma	Substitution - Missense
c.155A>G; p.D52G; 12:124913617-124913617	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.21T>C; p.T7T; 12:124913751-124913751	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1905G>A; p.K635K; 12:124911867-124911867	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.1880C>T; p.P627L; 12:124911892-124911892	skin	malignant_melanoma	Substitution - Missense
c.715A>G; p.K239E; 12:124913057-124913057	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.715A>G; p.K239E; 12:124913057-124913057	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.365C>T; p.A122V; 12:124913407-124913407	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.624G>A; p.L208L; 12:124913148-124913148	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1413C>T; p.L471L; 12:124912359-124912359	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1995_1996insT; p.D666fs*1; 12:124911776-124911777	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.340C>T; p.P114S; 12:124913432-124913432	skin	malignant_melanoma	Substitution - Missense
c.960A>G; p.E320E; 12:124912812-124912812	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.954T>C; p.T318T; 12:124912818-124912818	breast	carcinoma	Substitution - coding silent
c.954T>C; p.T318T; 12:124912818-124912818	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.294C>T; p.T98T; 12:124913478-124913478	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.294C>T; p.T98T; 12:124913478-124913478	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.396G>C; p.L132L; 12:124913376-124913376	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1074T>C; p.R358R; 12:124912698-124912698	thyroid	other; neoplasm	Substitution - coding silent
c.1911G>C; p.K637N; 12:124911861-124911861	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.512C>T; p.P171L; 12:124913260-124913260	skin	malignant_melanoma	Substitution - Missense
c.1815C>T; p.L605L; 12:124911957-124911957	skin	malignant_melanoma	Substitution - coding silent
c.1815C>T; p.L605L; 12:124911957-124911957	prostate	carcinoma	Substitution - coding silent
c.666A>G; p.V222V; 12:124913106-124913106	skin	malignant_melanoma	Substitution - coding silent
c.666A>G; p.V222V; 12:124913106-124913106	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.666A>G; p.V222V; 12:124913106-124913106	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.501C>T; p.L167L; 12:124913271-124913271	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.993G>A; p.K331K; 12:124912779-124912779	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.442C>T; p.R148C; 12:124913330-124913330	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1830A>G; p.Q610Q; 12:124911942-124911942	thyroid	other; neoplasm	Substitution - coding silent
c.1830A>G; p.Q610Q; 12:124911942-124911942	thyroid	other; neoplasm	Substitution - coding silent
c.1830A>G; p.Q610Q; 12:124911942-124911942	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.828G>A; p.K276K; 12:124912944-124912944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.968C>T; p.P323L; 12:124912804-124912804	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.828G>A; p.K276K; 12:124912944-124912944	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1354C>T; p.R452C; 12:124912418-124912418	breast	carcinoma	Substitution - Missense
c.204C>T; p.H68H; 12:124913568-124913568	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1133G>C; p.R378T; 12:124912639-124912639	breast	carcinoma	Substitution - Missense
c.1171A>G; p.K391E; 12:124912601-124912601	central_nervous_system; brain	glioma	Substitution - Missense
c.1666G>A; p.E556K; 12:124912106-124912106	urinary_tract; bladder	carcinoma	Substitution - Missense
c.622C>G; p.L208V; 12:124913150-124913150	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.88A>G; p.I30V; 12:124913684-124913684	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.88A>G; p.I30V; 12:124913684-124913684	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.156T>C; p.D52D; 12:124913616-124913616	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.315G>C; p.K105N; 12:124913457-124913457	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.903C>T; p.L301L; 12:124912869-124912869	skin	malignant_melanoma	Substitution - coding silent
c.1131C>T; p.L377L; 12:124912641-124912641	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.332_357del26; p.G111fs*15; 12:124913415-124913440	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.883C>T; p.L295L; 12:124912889-124912889	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.527A>C; p.E176A; 12:124913245-124913245	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.373C>G; p.Q125E; 12:124913399-124913399	breast	carcinoma	Substitution - Missense
c.372G>A; p.K124K; 12:124913400-124913400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.372G>A; p.K124K; 12:124913400-124913400	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.105C>A; p.G35G; 12:124913667-124913667	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1205C>T; p.T402I; 12:124912567-124912567	skin	malignant_melanoma	Substitution - Missense
c.288T>C; p.S96S; 12:124913484-124913484	breast	carcinoma	Substitution - coding silent
c.2051delG; p.G684fs*>2; 12:124911721-124911721	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1800C>T; p.H600H; 12:124911972-124911972	skin	malignant_melanoma	Substitution - coding silent
c.783_784GG>AA; p.E262K; 12:124912988-124912989	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2051delG; p.G684fs*>2; 12:124911721-124911721	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.228G>A; p.G76G; 12:124913544-124913544	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1977A>T; p.E659D; 12:124911795-124911795	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.413A>G; p.Q138R; 12:124913359-124913359	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.718A>G; p.T240A; 12:124913054-124913054	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.368G>C; p.G123A; 12:124913404-124913404	breast	carcinoma	Substitution - Missense
c.1687_1688insC; p.Q563fs*9; 12:124912084-124912085	breast	carcinoma	Insertion - Frameshift
c.1854_1855insT; p.K619fs*1; 12:124911917-124911918	pancreas	carcinoma; ductal_carcinoma	Insertion - Frameshift
c.1361G>C; p.R454T; 12:124912411-124912411	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1631_1632insC; p.I545fs*9; 12:124912140-124912141	breast	carcinoma	Insertion - Frameshift
c.544A>G; p.I182V; 12:124913228-124913228	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.388C>T; p.R130C; 12:124913384-124913384	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.777A>G; p.Q259Q; 12:124912995-124912995	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.328G>A; p.E110K; 12:124913444-124913444	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.317_329del13; p.I106fs*10; 12:124913443-124913455	breast	carcinoma	Deletion - Frameshift
c.1945C>T; p.Q649*; 12:124911827-124911827	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1020C>T; p.I340I; 12:124912752-124912752	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1020C>T; p.I340I; 12:124912752-124912752	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1071T>C; p.G357G; 12:124912701-124912701	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1351C>T; p.L451F; 12:124912421-124912421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1866C>T; p.T622T; 12:124911906-124911906	skin	malignant_melanoma	Substitution - coding silent
c.619A>G; p.T207A; 12:124913153-124913153	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1416A>G; p.E472E; 12:124912356-124912356	breast	carcinoma	Substitution - coding silent
c.1018A>T; p.I340F; 12:124912754-124912754	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1018A>T; p.I340F; 12:124912754-124912754	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1814T>C; p.L605P; 12:124911958-124911958	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.297C>T; p.I99I; 12:124913475-124913475	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.438G>T; p.V146V; 12:124913334-124913334	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1632_1633insC; p.I545fs*9; 12:124912139-124912140	breast	carcinoma	Insertion - Frameshift

COSMIC somatic mutation [Top]