Entrez Gene

Basic Information
Gene ID	701
Name	BUB1B
Synonymous	BUB1 mitotic checkpoint serine/threonine kinase B;BUB1B;BUB1 mitotic checkpoint serine/threonine kinase B
Definition	MAD3/BUB1-related protein kinase\|budding uninhibited by benzimidazoles 1 homolog beta\|mitotic checkpoint kinase MAD3L\|mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Position	15q15
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1925A>G; p.E642G; 15:40206374-40206374	stomach	carcinoma	Substitution - Missense
c.659C>G; p.S220C; 15:40183791-40183791	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1378C>G; p.Q460E; 15:40199704-40199704	breast	carcinoma	Substitution - Missense
c.2536G>A; p.D846N; 15:40213332-40213332	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2191C>T; p.L731L; 15:40209682-40209682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1545G>A; p.W515*; 15:40200958-40200958	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1923A>C; p.E641D; 15:40206372-40206372	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.186T>C; p.F62F; 15:40170068-40170068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.923T>C; p.L308P; 15:40185336-40185336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1246C>T; p.R416W; 15:40196732-40196732	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1006G>T; p.V336L; 15:40185590-40185590	liver	carcinoma	Substitution - Missense
c.1006G>T; p.V336L; 15:40185590-40185590	liver	carcinoma	Substitution - Missense
c.2553T>C; p.S851S; 15:40213349-40213349	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2179C>T; p.R727C; 15:40209670-40209670	urinary_tract; bladder	carcinoma	Substitution - Missense
c.858G>A; p.E286E; 15:40185271-40185271	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.452T>G; p.L151R; 15:40176544-40176544	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2678G>A; p.R893K; 15:40213474-40213474	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.588C>G; p.F196L; 15:40183720-40183720	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2784C>T; p.S928S; 15:40217601-40217601	central_nervous_system; brain	glioma	Substitution - coding silent
c.2570A>G; p.E857G; 15:40213366-40213366	liver	carcinoma	Substitution - Missense
c.2570A>G; p.E857G; 15:40213366-40213366	liver	carcinoma	Substitution - Missense
c.2176T>C; p.Y726H; 15:40209667-40209667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2570A>G; p.E857G; 15:40213366-40213366	liver	carcinoma	Substitution - Missense
c.1065A>G; p.P355P; 15:40196551-40196551	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2093T>A; p.I698N; 15:40208720-40208720	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1856C>G; p.S619C; 15:40206305-40206305	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1630C>T; p.P544S; 15:40202590-40202590	skin	malignant_melanoma	Substitution - Missense
c.1642C>T; p.P548S; 15:40202602-40202602	liver	carcinoma	Substitution - Missense
c.1872G>A; p.E624E; 15:40206321-40206321	breast	carcinoma	Substitution - coding silent
c.652G>C; p.E218Q; 15:40183784-40183784	breast	carcinoma	Substitution - Missense
c.1642C>T; p.P548S; 15:40202602-40202602	liver	carcinoma	Substitution - Missense
c.1828G>C; p.D610H; 15:40206277-40206277	skin; neck	malignant_melanoma	Substitution - Missense
c.2015T>G; p.I672S; 15:40208642-40208642	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1568-5T>C; p.?; 15:40202400-40202400	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.2738C>A; p.S913Y; 15:40217555-40217555	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.194A>G; p.E65G; 15:40170076-40170076	liver	carcinoma	Substitution - Missense
c.2524T>C; p.F842L; 15:40212637-40212637	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1647A>T; p.P549P; 15:40202607-40202607	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2534A>C; p.Q845P; 15:40212647-40212647	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.726C>T; p.I242I; 15:40183858-40183858	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1283delG; p.E429fs*5; 15:40196769-40196769	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.86T>A; p.V29E; 15:40165103-40165103	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.338A>C; p.K113T; 15:40170635-40170635	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2791C>T; p.R931W; 15:40217608-40217608	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2006T>C; p.L669P; 15:40206455-40206455	breast	carcinoma	Substitution - Missense
c.2967T>C; p.D989D; 15:40220573-40220573	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.388C>T; p.R130C; 15:40176480-40176480	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.388C>T; p.R130C; 15:40176480-40176480	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2800C>T; p.Q934*; 15:40217617-40217617	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2246C>T; p.P749L; 15:40209737-40209737	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1852G>C; p.V618L; 15:40206301-40206301	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1519G>A; p.E507K; 15:40200932-40200932	skin	malignant_melanoma	Substitution - Missense
c.1453G>A; p.E485K; 15:40200295-40200295	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.238A>T; p.R80W; 15:40170120-40170120	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1762A>G; p.S588G; 15:40206211-40206211	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2738C>T; p.S913F; 15:40217555-40217555	skin; scalp	malignant_melanoma	Substitution - Missense
c.1762A>G; p.S588G; 15:40206211-40206211	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1875A>G; p.I625M; 15:40206324-40206324	stomach	carcinoma	Substitution - Missense
c.242A>G; p.Y81C; 15:40170539-40170539	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.242A>G; p.Y81C; 15:40170539-40170539	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1187T>G; p.M396R; 15:40196673-40196673	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.343T>C; p.Y115H; 15:40170640-40170640	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.925C>T; p.Q309*; 15:40185338-40185338	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.1384G>A; p.E462K; 15:40199710-40199710	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2589T>G; p.I863M; 15:40213385-40213385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1230C>G; p.F410L; 15:40196716-40196716	urinary_tract; bladder	carcinoma	Substitution - Missense
c.111C>G; p.I37M; 15:40165128-40165128	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.111C>G; p.I37M; 15:40165128-40165128	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.365T>A; p.L122H; 15:40170662-40170662	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1894C>T; p.P632S; 15:40206343-40206343	skin	malignant_melanoma	Substitution - Missense
c.2690C>T; p.P897L; 15:40217507-40217507	skin	malignant_melanoma	Substitution - Missense
c.79G>A; p.E27K; 15:40165096-40165096	breast	carcinoma	Substitution - Missense
c.2523C>A; p.C841*; 15:40212636-40212636	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.613C>T; p.L205L; 15:40183745-40183745	skin	malignant_melanoma	Substitution - coding silent
c.357T>C; p.P119P; 15:40170654-40170654	skin	malignant_melanoma	Substitution - coding silent
c.1118A>C; p.K373T; 15:40196604-40196604	skin	malignant_melanoma	Substitution - Missense
c.2113G>A; p.E705K; 15:40208740-40208740	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2113G>A; p.E705K; 15:40208740-40208740	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2113G>A; p.E705K; 15:40208740-40208740	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.574C>T; p.Q192*; 15:40176666-40176666	skin	malignant_melanoma	Substitution - Nonsense
c.2229G>A; p.L743L; 15:40209720-40209720	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2437G>T; p.E813*; 15:40212550-40212550	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1977C>T; p.I659I; 15:40206426-40206426	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2996G>A; p.R999Q; 15:40220602-40220602	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.277G>A; p.G93R; 15:40170574-40170574	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2115G>T; p.E705D; 15:40208742-40208742	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1571C>T; p.P524L; 15:40202408-40202408	skin	malignant_melanoma	Substitution - Missense
c.1691C>G; p.S564*; 15:40202651-40202651	breast	carcinoma	Substitution - Nonsense
c.41C>T; p.A14V; 15:40165058-40165058	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1764C>T; p.S588S; 15:40206213-40206213	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1764C>T; p.S588S; 15:40206213-40206213	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1764C>T; p.S588S; 15:40206213-40206213	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1764C>T; p.S588S; 15:40206213-40206213	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.51_52GG>AA; p.E18K; 15:40165068-40165069	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2352G>A; p.A784A; 15:40210177-40210177	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.190T>A; p.Y64N; 15:40170072-40170072	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.3112G>A; p.V1038I; 15:40220718-40220718	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2660G>T; p.C887F; 15:40213456-40213456	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.208A>T; p.T70S; 15:40170090-40170090	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1552C>A; p.Q518K; 15:40200965-40200965	central_nervous_system; thalamus	glioma; astrocytoma_Grade_III	Substitution - Missense
c.3135G>A; p.G1045G; 15:40220741-40220741	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.3135G>A; p.G1045G; 15:40220741-40220741	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1587C>T; p.S529S; 15:40202424-40202424	skin	malignant_melanoma	Substitution - coding silent
c.2906T>C; p.L969P; 15:40218511-40218511	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.54G>T; p.E18D; 15:40165071-40165071	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2821A>T; p.I941F; 15:40217638-40217638	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2668C>A; p.L890I; 15:40213464-40213464	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1290C>T; p.A430A; 15:40199616-40199616	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1308A>C; p.A436A; 15:40199634-40199634	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3065delT; p.F1023fs*9; 15:40220671-40220671	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.538C>A; p.Q180K; 15:40176630-40176630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2792G>A; p.R931Q; 15:40217609-40217609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.627G>A; p.E209E; 15:40183759-40183759	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2361_2362delCT; p.S788fs*29; 15:40210186-40210187	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Deletion - Frameshift
c.2361_2362delCT; p.S788fs*29; 15:40210186-40210187	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.1859C>G; p.T620S; 15:40206308-40206308	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1846C>T; p.R616C; 15:40206295-40206295	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3016G>A; p.E1006K; 15:40220622-40220622	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2385+4G>A; p.?; 15:40210214-40210214	ovary	other; neoplasm	Unknown
c.2488G>T; p.D830Y; 15:40212601-40212601	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2110C>T; p.P704S; 15:40208737-40208737	skin	malignant_melanoma	Substitution - Missense
c.2351C>T; p.A784V; 15:40210176-40210176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2611G>A; p.E871K; 15:40213407-40213407	urinary_tract; bladder	carcinoma	Substitution - Missense
c.217G>T; p.D73Y; 15:40170099-40170099	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1363G>T; p.E455*; 15:40199689-40199689	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2988C>A; p.F996L; 15:40220594-40220594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.736G>A; p.G246R; 15:40183868-40183868	skin	malignant_melanoma	Substitution - Missense
c.2988C>A; p.F996L; 15:40220594-40220594	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.736G>A; p.G246R; 15:40183868-40183868	skin	malignant_melanoma	Substitution - Missense
c.2734T>C; p.F912L; 15:40217551-40217551	skin	malignant_melanoma	Substitution - Missense
c.2508C>T; p.H836H; 15:40212621-40212621	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.341G>A; p.R114Q; 15:40170638-40170638	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2030G>A; p.R677H; 15:40208657-40208657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1045C>A; p.R349R; 15:40185629-40185629	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.159T>C; p.N53N; 15:40165176-40165176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.327A>G; p.L109L; 15:40170624-40170624	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1152C>G; p.S384R; 15:40196638-40196638	liver	carcinoma	Substitution - Missense
c.1152C>G; p.S384R; 15:40196638-40196638	liver	carcinoma	Substitution - Missense
c.730C>T; p.R244C; 15:40183862-40183862	skin	malignant_melanoma	Substitution - Missense
c.276T>G; p.G92G; 15:40170573-40170573	breast	carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]