Entrez Gene

Basic Information
Gene ID	6876
Name	TAGLN
Synonymous	transgelin;TAGLN;transgelin
Definition	22 kDa actin-binding protein\|SM22-alpha\|smooth muscle protein 22-alpha\|transgelin variant 2
Position	11q23.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.104T>C; p.I35T; 11:117203117-117203117	urinary_tract; bladder	carcinoma	Substitution - Missense
c.277C>T; p.Q93*; 11:117203403-117203403	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.446C>T; p.P149L; 11:117203869-117203869	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.467C>T; p.A156V; 11:117204220-117204220	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.70G>A; p.E24K; 11:117203083-117203083	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.70G>A; p.E24K; 11:117203083-117203083	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.252C>T; p.P84P; 11:117203378-117203378	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.5C>T; p.A2V; 11:117203018-117203018	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.474G>A; p.E158E; 11:117204227-117204227	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.497G>A; p.S166N; 11:117204250-117204250	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.459G>A; p.M153I; 11:117203882-117203882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.436C>T; p.R146C; 11:117203859-117203859	large_intestine; colon	adenoma	Substitution - Missense
c.54C>T; p.I18I; 11:117203067-117203067	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.54C>T; p.I18I; 11:117203067-117203067	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.54C>T; p.I18I; 11:117203067-117203067	pancreas	carcinoma	Substitution - coding silent
c.7delA; p.N3fs*8; 11:117203020-117203020	prostate	carcinoma; adenocarcinoma	Deletion - Frameshift
c.267G>A; p.K89K; 11:117203393-117203393	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.267G>A; p.K89K; 11:117203393-117203393	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.16C>T; p.P6S; 11:117203029-117203029	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.48_49insA; p.I18fs*6; 11:117203061-117203062	skin	malignant_melanoma	Insertion - Frameshift
c.203G>T; p.S68I; 11:117203329-117203329	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.69C>T; p.D23D; 11:117203082-117203082	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.111G>A; p.Q37Q; 11:117203124-117203124	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.78G>A; p.L26L; 11:117203091-117203091	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.580G>A; p.G194R; 11:117204333-117204333	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.596T>C; p.I199T; 11:117204349-117204349	breast	carcinoma	Substitution - Missense
c.37G>A; p.E13K; 11:117203050-117203050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.227C>T; p.P76L; 11:117203353-117203353	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.322A>G; p.K108E; 11:117203448-117203448	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.92T>G; p.V31G; 11:117203105-117203105	thyroid	other; neoplasm	Substitution - Missense
c.92T>G; p.V31G; 11:117203105-117203105	thyroid	other; neoplasm	Substitution - Missense
c.92T>G; p.V31G; 11:117203105-117203105	thyroid	other; neoplasm	Substitution - Missense
c.92T>G; p.V31G; 11:117203105-117203105	thyroid	other; neoplasm	Substitution - Missense
c.564C>A; p.A188A; 11:117204317-117204317	breast	carcinoma	Substitution - coding silent
c.312T>C; p.Y104Y; 11:117203438-117203438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]