Entrez Gene

Basic Information
Gene ID	6257
Name	RXRB
Synonymous	retinoid X receptor, beta;RXRB;retinoid X receptor, beta
Definition	MHC class I promoter binding protein\|nuclear receptor subfamily 2 group B member 2\|retinoic acid receptor RXR-beta
Position	6p21.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1476T>G; p.R492R; 6:33194808-33194808	thyroid	other; neoplasm	Substitution - coding silent
c.706G>T; p.D236Y; 6:33197876-33197876	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1187T>C; p.L396P; 6:33195639-33195639	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.751A>G; p.K251E; 6:33197831-33197831	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.753G>A; p.K251K; 6:33197829-33197829	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.491C>G; p.S164*; 6:33198457-33198457	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.754C>T; p.R252C; 6:33197828-33197828	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1207G>T; p.V403L; 6:33195619-33195619	liver	carcinoma	Substitution - Missense
c.1207G>T; p.V403L; 6:33195619-33195619	liver	carcinoma	Substitution - Missense
c.1214G>A; p.R405H; 6:33195612-33195612	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.292C>T; p.P98S; 6:33199360-33199360	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.285C>T; p.V95V; 6:33199367-33199367	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.141G>A; p.A47A; 6:33200336-33200336	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1273G>A; p.V425M; 6:33195438-33195438	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1536C>T; p.L512L; 6:33194748-33194748	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.433C>G; p.L145V; 6:33199219-33199219	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1453C>T; p.R485W; 6:33194946-33194946	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.719C>G; p.S240C; 6:33197863-33197863	urinary_tract; bladder	carcinoma	Substitution - Missense
c.133C>T; p.P45S; 6:33200344-33200344	skin	malignant_melanoma	Substitution - Missense
c.1349-1G>T; p.?; 6:33195051-33195051	lung	carcinoma; adenocarcinoma	Unknown
c.980delG; p.G327fs*10; 6:33196447-33196447	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1107C>T; p.V369V; 6:33195923-33195923	skin	malignant_melanoma	Substitution - coding silent
c.807C>T; p.G269G; 6:33197775-33197775	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1351G>A; p.A451T; 6:33195048-33195048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.403G>T; p.V135F; 6:33199249-33199249	thyroid	other; neoplasm	Substitution - Missense
c.1476T>C; p.R492R; 6:33194808-33194808	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1220C>G; p.S407*; 6:33195606-33195606	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.629A>G; p.D210G; 6:33198319-33198319	liver	carcinoma	Substitution - Missense
c.1286delG; p.R429fs*3; 6:33195425-33195425	liver	carcinoma	Deletion - Frameshift
c.1501C>T; p.L501F; 6:33194783-33194783	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.1389G>A; p.L463L; 6:33195010-33195010	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1093C>G; p.L365V; 6:33195937-33195937	urinary_tract; bladder	carcinoma	Substitution - Missense
c.484A>T; p.I162F; 6:33198464-33198464	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1328C>T; p.A443V; 6:33195383-33195383	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.747G>A; p.V249V; 6:33197835-33197835	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.581C>T; p.P194L; 6:33198367-33198367	skin	malignant_melanoma	Substitution - Missense
c.1230A>G; p.S410S; 6:33195596-33195596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1229C>T; p.S410L; 6:33195597-33195597	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.527delC; p.P176fs*4; 6:33198421-33198421	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.271C>T; p.L91F; 6:33199381-33199381	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.79G>T; p.E27*; 6:33200398-33200398	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.881G>C; p.G294A; 6:33196546-33196546	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.964_965CC>TT; p.P322F; 6:33196462-33196463	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.701G>A; p.R234H; 6:33197881-33197881	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.762G>A; p.R254R; 6:33197820-33197820	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1524T>A; p.F508L; 6:33194760-33194760	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1319G>A; p.C440Y; 6:33195392-33195392	liver	carcinoma	Substitution - Missense
c.1257G>A; p.R419R; 6:33195454-33195454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.401C>T; p.P134L; 6:33199251-33199251	skin	malignant_melanoma	Substitution - Missense
c.602G>A; p.G201D; 6:33198346-33198346	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.658T>C; p.Y220H; 6:33197924-33197924	liver	carcinoma	Substitution - Missense
c.1152C>T; p.F384F; 6:33195674-33195674	thyroid	other; neoplasm	Substitution - coding silent
c.167G>A; p.G56E; 6:33200310-33200310	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1021C>T; p.Q341*; 6:33196009-33196009	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1454+8G>A; p.?; 6:33194937-33194937	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1434G>A; p.K478K; 6:33194965-33194965	liver	carcinoma	Substitution - coding silent
c.1222G>A; p.A408T; 6:33195604-33195604	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.656T>G; p.V219G; 6:33197926-33197926	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1174C>A; p.R392R; 6:33195652-33195652	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1554C>T; p.I518I; 6:33194730-33194730	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1215C>T; p.R405R; 6:33195611-33195611	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.580C>T; p.P194S; 6:33198368-33198368	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.838C>T; p.Q280*; 6:33196589-33196589	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.806G>A; p.G269D; 6:33197776-33197776	pleura	pulmonary_blastoma	Substitution - Missense
c.1582G>A; p.A528T; 6:33194702-33194702	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1582G>A; p.A528T; 6:33194702-33194702	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.845delG; p.G282fs*55; 6:33196582-33196582	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1071C>T; p.I357I; 6:33195959-33195959	urinary_tract; bladder	carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]