Entrez Gene

Basic Information
Gene ID	59277
Name	NTN4
Synonymous	netrin 4;NTN4;netrin 4
Definition	beta-netrin\|hepar-derived netrin-like protein\|netrin-4
Position	12q22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.823C>T; p.H275Y; 12:95737907-95737907	prostate	adenoma	Substitution - Missense
c.823C>T; p.H275Y; 12:95737907-95737907	skin	malignant_melanoma	Substitution - Missense
c.1678T>A; p.F560I; 12:95665882-95665882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1394+1G>A; p.?; 12:95683497-95683497	skin; face	carcinoma; squamous_cell_carcinoma	Unknown
c.464A>C; p.K155T; 12:95787060-95787060	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1671G>A; p.L557L; 12:95665889-95665889	skin	malignant_melanoma	Substitution - coding silent
c.134G>A; p.R45Q; 12:95787390-95787390	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1216C>T; p.P406S; 12:95683676-95683676	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1649A>T; p.K550M; 12:95665911-95665911	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1103G>A; p.G368E; 12:95710518-95710518	skin	malignant_melanoma	Substitution - Missense
c.435C>A; p.D145E; 12:95787089-95787089	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1029C>T; p.F343F; 12:95710592-95710592	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1029C>T; p.F343F; 12:95710592-95710592	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.938A>T; p.D313V; 12:95713265-95713265	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.E59K; 12:95787349-95787349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.E59K; 12:95787349-95787349	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.E59K; 12:95787349-95787349	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.987C>T; p.C329C; 12:95713216-95713216	prostate	carcinoma	Substitution - coding silent
c.209T>A; p.L70Q; 12:95787315-95787315	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1780G>A; p.D594N; 12:95659193-95659193	NS	malignant_melanoma	Substitution - Missense
c.323C>G; p.S108C; 12:95787201-95787201	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - Missense
c.900A>C; p.A300A; 12:95713303-95713303	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.900A>C; p.A300A; 12:95713303-95713303	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.217C>T; p.R73W; 12:95787307-95787307	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.217C>T; p.R73W; 12:95787307-95787307	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.806A>C; p.D269A; 12:95737924-95737924	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.914A>G; p.Q305R; 12:95713289-95713289	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1285C>T; p.R429*; 12:95683607-95683607	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1210G>A; p.V404I; 12:95683682-95683682	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1202G>A; p.G401E; 12:95683690-95683690	skin	malignant_melanoma	Substitution - Missense
c.1084T>A; p.C362S; 12:95710537-95710537	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.326C>T; p.A109V; 12:95787198-95787198	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.613T>C; p.Y205H; 12:95738117-95738117	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.787T>A; p.F263I; 12:95737943-95737943	skin	malignant_melanoma	Substitution - Missense
c.1122C>T; p.C374C; 12:95710499-95710499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.568C>T; p.P190S; 12:95786956-95786956	skin	malignant_melanoma	Substitution - Missense
c.568C>T; p.P190S; 12:95786956-95786956	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1681C>T; p.R561*; 12:95665879-95665879	skin	malignant_melanoma	Substitution - Nonsense
c.265C>T; p.H89Y; 12:95787259-95787259	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.265C>T; p.H89Y; 12:95787259-95787259	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.265C>T; p.H89Y; 12:95787259-95787259	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1441G>A; p.V481M; 12:95682776-95682776	prostate	carcinoma	Substitution - Missense
c.1138C>T; p.R380C; 12:95710483-95710483	skin	malignant_melanoma	Substitution - Missense
c.1138C>T; p.R380C; 12:95710483-95710483	skin	malignant_melanoma	Substitution - Missense
c.1628A>G; p.E543G; 12:95665932-95665932	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1652T>C; p.V551A; 12:95665908-95665908	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1236C>T; p.F412F; 12:95683656-95683656	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1236C>T; p.F412F; 12:95683656-95683656	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.91G>A; p.E31K; 12:95787433-95787433	skin	malignant_melanoma	Substitution - Missense
c.1012G>A; p.A338T; 12:95710609-95710609	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1516T>C; p.C506R; 12:95670141-95670141	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1425T>C; p.V475V; 12:95682792-95682792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1753T>G; p.L585V; 12:95659220-95659220	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.676G>T; p.V226L; 12:95738054-95738054	liver	carcinoma	Substitution - Missense
c.1518C>T; p.C506C; 12:95670139-95670139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1181C>T; p.P394L; 12:95683711-95683711	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1181C>T; p.P394L; 12:95683711-95683711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1181C>T; p.P394L; 12:95683711-95683711	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1473G>A; p.W491*; 12:95682744-95682744	skin	malignant_melanoma	Substitution - Nonsense
c.1473G>A; p.W491*; 12:95682744-95682744	skin	malignant_melanoma	Substitution - Nonsense
c.1060C>T; p.R354C; 12:95710561-95710561	skin	malignant_melanoma	Substitution - Missense
c.802G>C; p.A268P; 12:95737928-95737928	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1276delG; p.V426fs*44; 12:95683616-95683616	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.981C>T; p.N327N; 12:95713222-95713222	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1141G>A; p.D381N; 12:95710480-95710480	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.490T>C; p.C164R; 12:95787034-95787034	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.203C>T; p.T68M; 12:95787321-95787321	central_nervous_system; brain	glioma	Substitution - Missense
c.203C>T; p.T68M; 12:95787321-95787321	central_nervous_system; brain	glioma	Substitution - Missense
c.361C>T; p.L121L; 12:95787163-95787163	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.982G>A; p.E328K; 12:95713221-95713221	skin	malignant_melanoma	Substitution - Missense
c.982G>A; p.E328K; 12:95713221-95713221	skin	malignant_melanoma	Substitution - Missense
c.982G>A; p.E328K; 12:95713221-95713221	skin	malignant_melanoma	Substitution - Missense
c.982G>A; p.E328K; 12:95713221-95713221	skin	malignant_melanoma	Substitution - Missense
c.1168G>T; p.D390Y; 12:95710453-95710453	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.133C>T; p.R45*; 12:95787391-95787391	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.768C>T; p.F256F; 12:95737962-95737962	skin	malignant_melanoma	Substitution - coding silent
c.1883A>G; p.K628R; 12:95659090-95659090	skin	malignant_melanoma	Substitution - Missense
c.703C>G; p.P235A; 12:95738027-95738027	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.381C>A; p.F127L; 12:95787143-95787143	NS	NS	Substitution - Missense
c.940C>T; p.R314W; 12:95713263-95713263	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1182G>A; p.P394P; 12:95683710-95683710	breast	carcinoma	Substitution - coding silent
c.1369C>A; p.P457T; 12:95683523-95683523	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1369C>A; p.P457T; 12:95683523-95683523	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1379G>A; p.G460E; 12:95683513-95683513	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.275C>T; p.S92F; 12:95787249-95787249	breast	carcinoma	Substitution - Missense
c.364G>A; p.E122K; 12:95787160-95787160	skin	malignant_melanoma	Substitution - Missense
c.1134C>G; p.F378L; 12:95710487-95710487	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1680C>T; p.F560F; 12:95665880-95665880	skin	malignant_melanoma	Substitution - coding silent
c.328G>A; p.E110K; 12:95787196-95787196	skin	malignant_melanoma	Substitution - Missense
c.1712G>A; p.W571*; 12:95665848-95665848	skin	malignant_melanoma	Substitution - Nonsense
c.20T>G; p.L7R; 12:95790290-95790290	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1007G>C; p.G336A; 12:95710614-95710614	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1308G>A; p.V436V; 12:95683584-95683584	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1030G>A; p.D344N; 12:95710591-95710591	skin	malignant_melanoma	Substitution - Missense
c.1777G>A; p.E593K; 12:95659196-95659196	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1777G>A; p.E593K; 12:95659196-95659196	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1301G>C; p.C434S; 12:95683591-95683591	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1838C>A; p.P613H; 12:95659135-95659135	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1148G>A; p.R383Q; 12:95710473-95710473	skin	malignant_melanoma	Substitution - Missense
c.1148G>A; p.R383Q; 12:95710473-95710473	skin	malignant_melanoma	Substitution - Missense
c.658A>G; p.K220E; 12:95738072-95738072	skin; trunk	malignant_melanoma	Substitution - Missense
c.338A>C; p.H113P; 12:95787186-95787186	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.109C>T; p.R37W; 12:95787415-95787415	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.114G>A; p.M38I; 12:95787410-95787410	skin	malignant_melanoma	Substitution - Missense
c.1456G>A; p.E486K; 12:95682761-95682761	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.408C>T; p.S136S; 12:95787116-95787116	skin	malignant_melanoma	Substitution - coding silent
c.1325G>A; p.G442E; 12:95683567-95683567	skin	malignant_melanoma	Substitution - Missense
c.999G>T; p.K333N; 12:95710622-95710622	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.999G>T; p.K333N; 12:95710622-95710622	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1355C>T; p.A452V; 12:95683537-95683537	pancreas	carcinoma	Substitution - Missense
c.1355C>T; p.A452V; 12:95683537-95683537	pancreas	carcinoma	Substitution - Missense
c.622G>A; p.E208K; 12:95738108-95738108	skin	malignant_melanoma	Substitution - Missense
c.1149G>A; p.R383R; 12:95710472-95710472	skin	malignant_melanoma	Substitution - coding silent
c.506G>A; p.G169D; 12:95787018-95787018	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1165C>T; p.P389S; 12:95710456-95710456	skin	malignant_melanoma	Substitution - Missense
c.375C>A; p.F125L; 12:95787149-95787149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2T>C; p.M1T; 12:95790308-95790308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1418A>C; p.H473P; 12:95682799-95682799	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.733C>A; p.P245T; 12:95737997-95737997	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1418A>C; p.H473P; 12:95682799-95682799	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.417G>T; p.P139P; 12:95787107-95787107	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1220C>T; p.A407V; 12:95683672-95683672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.333T>G; p.D111E; 12:95787191-95787191	thyroid	carcinoma	Substitution - Missense
c.1723G>A; p.G575R; 12:95665837-95665837	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1843C>T; p.L615F; 12:95659130-95659130	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.304C>T; p.P102S; 12:95787220-95787220	skin	malignant_melanoma	Substitution - Missense
c.949G>A; p.E317K; 12:95713254-95713254	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.949G>A; p.E317K; 12:95713254-95713254	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1600T>C; p.S534P; 12:95665960-95665960	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1515A>G; p.K505K; 12:95670142-95670142	breast	carcinoma	Substitution - coding silent
c.615C>A; p.Y205*; 12:95738115-95738115	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.95A>G; p.K32R; 12:95787429-95787429	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1356G>A; p.A452A; 12:95683536-95683536	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.535G>A; p.A179T; 12:95786989-95786989	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1838C>G; p.P613R; 12:95659135-95659135	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1172C>G; p.A391G; 12:95710449-95710449	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.751T>C; p.Y251H; 12:95737979-95737979	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1142A>G; p.D381G; 12:95710479-95710479	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]