Entrez Gene

Basic Information
Gene ID	57472
Name	CNOT6
Synonymous	CCR4-NOT transcription complex, subunit 6;CNOT6;CCR4-NOT transcription complex, subunit 6
Definition	CCR4-NOT transcription complex subunit 6\|carbon catabolite repression 4 protein\|carbon catabolite repressor protein 4 homolog\|cytoplasmic deadenylase
Position	5q35.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1217C>T; p.P406L; 5:180569299-180569299	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1072G>T; p.A358S; 5:180569154-180569154	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1025C>T; p.P342L; 5:180568001-180568001	stomach	adenocarcinoma	Substitution - Missense
c.1417G>C; p.E473Q; 5:180571388-180571388	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.684C>G; p.I228M; 5:180565944-180565944	skin	malignant_melanoma	Substitution - Missense
c.614A>G; p.Q205R; 5:180565874-180565874	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.972T>C; p.D324D; 5:180567948-180567948	liver	carcinoma	Substitution - coding silent
c.1004G>A; p.R335Q; 5:180567980-180567980	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.R87C; 5:180550077-180550077	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.R87C; 5:180550077-180550077	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.R87C; 5:180550077-180550077	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.461T>C; p.L154P; 5:180564564-180564564	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.26C>T; p.P9L; 5:180529302-180529302	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.452A>G; p.N151S; 5:180564555-180564555	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1244C>A; p.S415Y; 5:180569326-180569326	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1244C>A; p.S415Y; 5:180569326-180569326	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1515C>A; p.I505I; 5:180574041-180574041	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.605C>T; p.A202V; 5:180565865-180565865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1487C>A; p.S496Y; 5:180574013-180574013	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1355A>G; p.H452R; 5:180571326-180571326	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.748T>C; p.F250L; 5:180567118-180567118	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.684C>A; p.I228I; 5:180565944-180565944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.773G>T; p.G258V; 5:180567143-180567143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1629T>G; p.P543P; 5:180574155-180574155	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1577T>C; p.L526P; 5:180574103-180574103	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.612G>A; p.R204R; 5:180565872-180565872	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.200C>T; p.P67L; 5:180550018-180550018	skin	malignant_melanoma	Substitution - Missense
c.1571A>C; p.H524P; 5:180574097-180574097	breast	carcinoma	Substitution - Missense
c.1314G>A; p.K438K; 5:180571285-180571285	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.759G>A; p.E253E; 5:180567129-180567129	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.883G>C; p.V295L; 5:180567859-180567859	ovary	other; neoplasm	Substitution - Missense
c.883G>C; p.V295L; 5:180567859-180567859	ovary	other; neoplasm	Substitution - Missense
c.185C>T; p.S62F; 5:180550003-180550003	skin	malignant_melanoma	Substitution - Missense
c.482C>G; p.A161G; 5:180564585-180564585	thyroid	other; neoplasm	Substitution - Missense
c.1066C>A; p.L356I; 5:180569148-180569148	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1172C>T; p.S391F; 5:180569254-180569254	breast	carcinoma	Substitution - Missense
c.743_744insT; p.L251fs*10; 5:180567113-180567114	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.772G>T; p.G258C; 5:180567142-180567142	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.87C>T; p.S29S; 5:180529363-180529363	skin	malignant_melanoma	Substitution - coding silent
c.132C>A; p.S44R; 5:180549950-180549950	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1066C>G; p.L356V; 5:180569148-180569148	breast	carcinoma	Substitution - Missense
c.464A>C; p.D155A; 5:180564567-180564567	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1144G>A; p.E382K; 5:180569226-180569226	skin	malignant_melanoma	Substitution - Missense
c.898G>C; p.V300L; 5:180567874-180567874	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.55T>G; p.S19A; 5:180529331-180529331	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.244T>C; p.S82P; 5:180550062-180550062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1558_1559delAG; p.S520fs*10; 5:180574084-180574085	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1190G>C; p.S397T; 5:180569272-180569272	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1507delT; p.L503fs*1; 5:180574033-180574033	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.991C>T; p.L331L; 5:180567967-180567967	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.80A>G; p.K27R; 5:180529356-180529356	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.873-2A>T; p.?; 5:180567847-180567847	autonomic_ganglia	neuroblastoma	Unknown
c.873-2A>T; p.?; 5:180567847-180567847	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.910C>T; p.Q304*; 5:180567886-180567886	skin	malignant_melanoma	Substitution - Nonsense
c.1283G>A; p.G428D; 5:180571254-180571254	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1345T>G; p.F449V; 5:180571316-180571316	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.755T>C; p.V252A; 5:180567125-180567125	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.272C>T; p.A91V; 5:180550090-180550090	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.576G>T; p.M192I; 5:180565836-180565836	skin	malignant_melanoma	Substitution - Missense
c.463G>A; p.D155N; 5:180564566-180564566	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1648G>A; p.G550S; 5:180574174-180574174	breast	carcinoma	Substitution - Missense
c.1445A>G; p.Y482C; 5:180571416-180571416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606G>A; p.A202A; 5:180565866-180565866	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.641C>T; p.A214V; 5:180565901-180565901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1142C>G; p.S381*; 5:180569224-180569224	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.769C>T; p.R257C; 5:180567139-180567139	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.698C>A; p.A233D; 5:180565958-180565958	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.602A>G; p.Y201C; 5:180565862-180565862	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1182C>T; p.L394L; 5:180569264-180569264	skin	malignant_melanoma	Substitution - coding silent
c.1425C>T; p.G475G; 5:180571396-180571396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1465A>C; p.I489L; 5:180573991-180573991	urinary_tract; bladder	carcinoma	Substitution - Missense
c.574A>G; p.M192V; 5:180565834-180565834	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1434T>G; p.P478P; 5:180571405-180571405	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.922G>A; p.A308T; 5:180567898-180567898	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.491-2A>G; p.?; 5:180564673-180564673	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1014G>A; p.S338S; 5:180567990-180567990	skin	malignant_melanoma	Substitution - coding silent
c.491T>A; p.I164N; 5:180564675-180564675	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.475G>T; p.G159C; 5:180564578-180564578	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1004G>T; p.R335L; 5:180567980-180567980	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1079C>T; p.A360V; 5:180569161-180569161	skin	malignant_melanoma	Substitution - Missense
c.1191T>C; p.S397S; 5:180569273-180569273	breast	carcinoma	Substitution - coding silent
c.1088_1089insT; p.W364fs*4; 5:180569170-180569171	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.328C>T; p.R110*; 5:180553414-180553414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.328C>T; p.R110*; 5:180553414-180553414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.328C>T; p.R110*; 5:180553414-180553414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.973A>G; p.N325D; 5:180567949-180567949	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1462G>T; p.G488C; 5:180573988-180573988	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1121T>C; p.V374A; 5:180569203-180569203	thyroid	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]