Entrez Gene

Basic Information
Gene ID	51433
Name	ANAPC5
Synonymous	anaphase promoting complex subunit 5;ANAPC5;anaphase promoting complex subunit 5
Definition	anaphase-promoting complex subunit 5\|cyclosome subunit 5
Position	12q24.31
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1550A>G; p.D517G; 12:121319784-121319784	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.759G>A; p.A253A; 12:121337291-121337291	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2257A>G; p.N753D; 12:121308491-121308491	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1799C>T; p.A600V; 12:121318371-121318371	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1797C>T; p.I599I; 12:121318373-121318373	breast	carcinoma	Substitution - coding silent
c.1073A>G; p.Y358C; 12:121330632-121330632	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.1073A>G; p.Y358C; 12:121330632-121330632	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1969A>G; p.I657V; 12:121309788-121309788	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1310T>C; p.M437T; 12:121327226-121327226	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.214G>C; p.D72H; 12:121347875-121347875	pancreas	carcinoma	Substitution - Missense
c.2213G>A; p.R738Q; 12:121308535-121308535	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1984C>T; p.R662C; 12:121309773-121309773	breast	carcinoma	Substitution - Missense
c.1988C>T; p.A663V; 12:121309769-121309769	skin	malignant_melanoma	Substitution - Missense
c.2202G>A; p.A734A; 12:121308546-121308546	breast	carcinoma	Substitution - coding silent
c.1509C>T; p.H503H; 12:121320391-121320391	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.637G>T; p.E213*; 12:121342023-121342023	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.697C>A; p.P233T; 12:121337353-121337353	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1095G>A; p.V365V; 12:121330610-121330610	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.353C>T; p.S118F; 12:121346940-121346940	skin	malignant_melanoma	Substitution - Missense
c.1515+2T>A; p.?; 12:121320383-121320383	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.623C>T; p.S208F; 12:121342037-121342037	skin	malignant_melanoma	Substitution - Missense
c.951-8G>A; p.?; 12:121331436-121331436	pancreas	carcinoma	Unknown
c.951-8G>A; p.?; 12:121331436-121331436	pancreas	carcinoma	Unknown
c.1148C>T; p.S383F; 12:121328472-121328472	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1404C>T; p.V468V; 12:121327132-121327132	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1909C>T; p.P637S; 12:121309848-121309848	skin	malignant_melanoma	Substitution - Missense
c.2163C>T; p.Y721Y; 12:121308585-121308585	skin	malignant_melanoma	Substitution - coding silent
c.1516-9delT; p.?; 12:121319827-121319827	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.770G>A; p.S257N; 12:121335713-121335713	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.630delA; p.K210fs*14; 12:121342030-121342030	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.69G>C; p.V23V; 12:121352272-121352272	central_nervous_system; brain	glioma	Substitution - coding silent
c.1926T>A; p.S642R; 12:121309831-121309831	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.582A>G; p.V194V; 12:121345847-121345847	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.788G>A; p.R263H; 12:121335695-121335695	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.891C>T; p.G297G; 12:121335592-121335592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1515+1G>T; p.?; 12:121320384-121320384	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.65A>G; p.N22S; 12:121352276-121352276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.677A>T; p.D226V; 12:121337373-121337373	breast	carcinoma	Substitution - Missense
c.1651T>C; p.L551L; 12:121318595-121318595	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2253G>C; p.L751F; 12:121308495-121308495	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1746-7C>T; p.?; 12:121318431-121318431	pancreas	carcinoma	Unknown
c.1746-7C>T; p.?; 12:121318431-121318431	pancreas	carcinoma	Unknown
c.1746-7C>T; p.?; 12:121318431-121318431	pancreas	carcinoma	Unknown
c.1516-9_1516-8insT; p.?; 12:121319826-121319827	skin	malignant_melanoma	Unknown
c.610A>G; p.S204G; 12:121342050-121342050	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1630G>A; p.V544I; 12:121319704-121319704	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.610A>G; p.S204G; 12:121342050-121342050	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2118C>T; p.C706C; 12:121308630-121308630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1258A>G; p.I420V; 12:121328362-121328362	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1256A>G; p.D419G; 12:121328364-121328364	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.725A>C; p.N242T; 12:121337325-121337325	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.422T>G; p.L141W; 12:121346007-121346007	liver	carcinoma	Substitution - Missense
c.422T>G; p.L141W; 12:121346007-121346007	liver	carcinoma	Substitution - Missense
c.1091_1118del28; p.S364fs*26; 12:121330587-121330614	skin	malignant_melanoma	Deletion - Frameshift
c.858C>G; p.A286A; 12:121335625-121335625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1313C>T; p.A438V; 12:121327223-121327223	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1006G>A; p.D336N; 12:121331373-121331373	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2035delG; p.D679fs*73; 12:121309722-121309722	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1519T>C; p.W507R; 12:121319815-121319815	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.821T>C; p.L274P; 12:121335662-121335662	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.887A>G; p.Y296C; 12:121335596-121335596	liver	carcinoma	Substitution - Missense
c.887A>G; p.Y296C; 12:121335596-121335596	liver	carcinoma	Substitution - Missense
c.2185G>T; p.E729*; 12:121308563-121308563	breast	carcinoma	Substitution - Nonsense
c.1832C>T; p.S611F; 12:121318338-121318338	skin	malignant_melanoma	Substitution - Missense
c.724A>T; p.N242Y; 12:121337326-121337326	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.288-5T>G; p.?; 12:121347010-121347010	liver	carcinoma	Unknown
c.1745+3A>G; p.?; 12:121318498-121318498	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1208A>T; p.K403M; 12:121328412-121328412	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.652C>A; p.Q218K; 12:121342008-121342008	skin	malignant_melanoma	Substitution - Missense
c.271A>C; p.N91H; 12:121347818-121347818	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1209G>A; p.K403K; 12:121328411-121328411	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1651T>G; p.L551V; 12:121318595-121318595	skin	malignant_melanoma	Substitution - Missense
c.1300C>T; p.R434C; 12:121328320-121328320	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3G>A; p.M1I; 12:121352338-121352338	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.230A>T; p.K77I; 12:121347859-121347859	breast	carcinoma	Substitution - Missense
c.1492C>T; p.P498S; 12:121320408-121320408	skin	malignant_melanoma	Substitution - Missense
c.521A>G; p.D174G; 12:121345908-121345908	liver	carcinoma	Substitution - Missense
c.1195A>T; p.M399L; 12:121328425-121328425	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.521A>G; p.D174G; 12:121345908-121345908	liver	carcinoma	Substitution - Missense
c.705C>A; p.S235S; 12:121337345-121337345	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1851G>T; p.Q617H; 12:121318319-121318319	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.2159T>C; p.L720P; 12:121308589-121308589	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1851G>T; p.Q617H; 12:121318319-121318319	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1165G>A; p.A389T; 12:121328455-121328455	thyroid	carcinoma	Substitution - Missense
c.1592T>G; p.L531R; 12:121319742-121319742	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2245G>A; p.V749I; 12:121308503-121308503	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.909C>T; p.A303A; 12:121335574-121335574	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1074T>C; p.Y358Y; 12:121330631-121330631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1230G>A; p.W410*; 12:121328390-121328390	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.145G>T; p.E49*; 12:121352196-121352196	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1576C>T; p.H526Y; 12:121319758-121319758	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1076T>C; p.V359A; 12:121330629-121330629	ovary	other; neoplasm	Substitution - Missense
c.1800G>A; p.A600A; 12:121318370-121318370	breast	carcinoma	Substitution - coding silent
c.1800G>A; p.A600A; 12:121318370-121318370	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1259T>C; p.I420T; 12:121328361-121328361	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1255G>T; p.D419Y; 12:121328365-121328365	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2079C>A; p.N693K; 12:121308669-121308669	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.410G>A; p.R137H; 12:121346019-121346019	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1170delT; p.F390fs*9; 12:121328450-121328450	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1980A>G; p.K660K; 12:121309777-121309777	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1980A>G; p.K660K; 12:121309777-121309777	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1624G>C; p.E542Q; 12:121319710-121319710	breast	carcinoma	Substitution - Missense
c.2201C>T; p.A734V; 12:121308547-121308547	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2201C>T; p.A734V; 12:121308547-121308547	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2201C>T; p.A734V; 12:121308547-121308547	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.15C>T; p.H5H; 12:121352326-121352326	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.299T>G; p.M100R; 12:121346994-121346994	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.195G>A; p.L65L; 12:121352146-121352146	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1011C>T; p.H337H; 12:121331368-121331368	central_nervous_system; brain	glioma	Substitution - coding silent
c.1504C>T; p.Q502*; 12:121320396-121320396	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1431C>T; p.H477H; 12:121327105-121327105	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1453_1454GC>AT; p.A485I; 12:121320446-121320447	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.529C>T; p.L177L; 12:121345900-121345900	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.861A>G; p.E287E; 12:121335622-121335622	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.653A>G; p.Q218R; 12:121342007-121342007	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.271A>G; p.N91D; 12:121347818-121347818	breast	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]