Entrez Gene

Basic Information
Gene ID	4790
Name	NFKB1
Synonymous	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1;NFKB1;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Definition	DNA binding factor KBF1\|DNA-binding factor KBF1\|NF-kappabeta\|nuclear factor NF-kappa-B p105 subunit\|nuclear factor NF-kappa-B p50 subunit\|nuclear factor kappa-B DNA binding subunit
Position	4q24
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1813G>A; p.A605T; 4:102606556-102606556	liver	carcinoma	Substitution - Missense
c.1813G>A; p.A605T; 4:102606556-102606556	liver	carcinoma	Substitution - Missense
c.40-1G>A; p.?; 4:102529835-102529835	breast	carcinoma; ductal_carcinoma	Unknown
c.923G>T; p.R308I; 4:102582953-102582953	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.474G>A; p.M158I; 4:102576942-102576942	liver	carcinoma	Substitution - Missense
c.474G>A; p.M158I; 4:102576942-102576942	liver	carcinoma	Substitution - Missense
c.192C>T; p.G64G; 4:102537890-102537890	skin	malignant_melanoma	Substitution - coding silent
c.574C>T; p.R192W; 4:102578883-102578883	breast	carcinoma	Substitution - Missense
c.506G>A; p.G169E; 4:102576974-102576974	skin	malignant_melanoma	Substitution - Missense
c.40-1G>A; p.?; 4:102529835-102529835	breast	carcinoma; ductal_carcinoma	Unknown
c.1297C>G; p.H433D; 4:102594978-102594978	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.210A>G; p.L70L; 4:102537908-102537908	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.210A>G; p.L70L; 4:102537908-102537908	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.169C>T; p.R57C; 4:102537867-102537867	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1032_1033insC; p.P347fs*7; 4:102584786-102584787	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1115C>T; p.S372L; 4:102593473-102593473	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1125C>T; p.F375F; 4:102593483-102593483	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2803C>T; p.R935C; 4:102616487-102616487	skin	malignant_melanoma	Substitution - Missense
c.1003C>A; p.R335R; 4:102584757-102584757	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.868G>T; p.E290*; 4:102582898-102582898	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1237C>T; p.P413S; 4:102594918-102594918	skin	malignant_melanoma	Substitution - Missense
c.1715C>T; p.S572F; 4:102600972-102600972	breast	carcinoma	Substitution - Missense
c.174C>T; p.F58F; 4:102537872-102537872	skin	malignant_melanoma	Substitution - coding silent
c.961G>T; p.D321Y; 4:102584715-102584715	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.424A>G; p.I142V; 4:102576892-102576892	liver	carcinoma	Substitution - Missense
c.424A>G; p.I142V; 4:102576892-102576892	liver	carcinoma	Substitution - Missense
c.2778C>T; p.C926C; 4:102616462-102616462	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2691G>A; p.K897K; 4:102613523-102613523	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.981A>G; p.P327P; 4:102584735-102584735	liver	carcinoma	Substitution - coding silent
c.407G>A; p.G136D; 4:102567135-102567135	skin; trunk	malignant_melanoma	Substitution - Missense
c.1291A>C; p.M431L; 4:102594972-102594972	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1948G>A; p.G650R; 4:102606691-102606691	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.182T>C; p.V61A; 4:102537880-102537880	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.524A>T; p.D175V; 4:102576992-102576992	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.796G>T; p.G266W; 4:102580600-102580600	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.33T>C; p.P11P; 4:102525551-102525551	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2521_2522GG>TT; p.G841F; 4:102612535-102612536	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1474G>T; p.E492*; 4:102596311-102596311	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1311C>A; p.D437E; 4:102596148-102596148	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.222T>G; p.S74S; 4:102537920-102537920	skin	malignant_melanoma	Substitution - coding silent
c.1820C>T; p.A607V; 4:102606563-102606563	skin	malignant_melanoma	Substitution - Missense
c.1852T>G; p.S618A; 4:102606595-102606595	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1004G>A; p.R335Q; 4:102584758-102584758	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1004G>A; p.R335Q; 4:102584758-102584758	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2811C>G; p.L937L; 4:102616495-102616495	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2023G>T; p.G675W; 4:102607218-102607218	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2711C>T; p.S904L; 4:102613543-102613543	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2510C>T; p.A837V; 4:102612524-102612524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1841G>A; p.R614H; 4:102606584-102606584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1841G>A; p.R614H; 4:102606584-102606584	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.569G>A; p.G190E; 4:102577037-102577037	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1378G>T; p.G460W; 4:102596215-102596215	skin	malignant_melanoma	Substitution - Missense
c.1196G>A; p.G399E; 4:102593554-102593554	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1137T>C; p.S379S; 4:102593495-102593495	liver	carcinoma	Substitution - coding silent
c.2648C>T; p.T883I; 4:102613480-102613480	urinary_tract; bladder	carcinoma	Substitution - Missense
c.733G>A; p.A245T; 4:102580537-102580537	breast	carcinoma	Substitution - Missense
c.1137T>C; p.S379S; 4:102593495-102593495	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.851G>T; p.R284L; 4:102582881-102582881	stomach	adenocarcinoma	Substitution - Missense
c.1137T>C; p.S379S; 4:102593495-102593495	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.209T>C; p.L70P; 4:102537907-102537907	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2116C>T; p.L706F; 4:102607311-102607311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2401G>A; p.D801N; 4:102612092-102612092	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2749+3_2749+4insA; p.?; 4:102613584-102613585	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Unknown
c.978A>C; p.K326N; 4:102584732-102584732	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.930T>G; p.F310L; 4:102584684-102584684	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.906C>T; p.S302S; 4:102582936-102582936	skin	malignant_melanoma	Substitution - coding silent
c.315A>T; p.K105N; 4:102567043-102567043	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2269C>T; p.L757L; 4:102610616-102610616	kidney	other; neoplasm	Substitution - coding silent
c.1974A>G; p.L658L; 4:102607169-102607169	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1698C>G; p.V566V; 4:102600955-102600955	breast	carcinoma	Substitution - coding silent
c.1861C>T; p.H621Y; 4:102606604-102606604	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2488G>A; p.D830N; 4:102612502-102612502	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2422G>A; p.D808N; 4:102612436-102612436	skin	malignant_melanoma	Substitution - Missense
c.655G>A; p.A219T; 4:102578964-102578964	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.16C>T; p.P6S; 4:102525534-102525534	skin	malignant_melanoma	Substitution - Missense
c.106G>A; p.A36T; 4:102529902-102529902	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1969C>T; p.H657Y; 4:102607164-102607164	liver	carcinoma	Substitution - Missense
c.1969C>T; p.H657Y; 4:102607164-102607164	liver	carcinoma	Substitution - Missense
c.1827G>A; p.L609L; 4:102606570-102606570	breast	carcinoma	Substitution - coding silent
c.1155C>T; p.G385G; 4:102593513-102593513	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1840C>T; p.R614C; 4:102606583-102606583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1840C>T; p.R614C; 4:102606583-102606583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2410C>G; p.L804V; 4:102612101-102612101	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2236C>T; p.P746S; 4:102610583-102610583	skin	malignant_melanoma	Substitution - Missense
c.2104G>A; p.A702T; 4:102607299-102607299	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1831C>T; p.L611F; 4:102606574-102606574	skin; neck	malignant_melanoma	Substitution - Missense
c.666G>A; p.P222P; 4:102578975-102578975	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1129G>A; p.G377S; 4:102593487-102593487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1348A>C; p.S450R; 4:102596185-102596185	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2779G>A; p.D927N; 4:102616463-102616463	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.666G>A; p.P222P; 4:102578975-102578975	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1395C>T; p.T465T; 4:102596232-102596232	skin	malignant_melanoma	Substitution - coding silent
c.1184G>T; p.G395V; 4:102593542-102593542	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2325G>A; p.T775T; 4:102610672-102610672	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.838G>T; p.D280Y; 4:102582868-102582868	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1848T>C; p.G616G; 4:102606591-102606591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2791G>A; p.E931K; 4:102616475-102616475	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2819C>T; p.T940I; 4:102616503-102616503	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.134T>C; p.L45P; 4:102533860-102533860	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2187G>T; p.G729G; 4:102607711-102607711	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.332C>T; p.A111V; 4:102567060-102567060	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2765G>T; p.S922I; 4:102616449-102616449	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1555G>A; p.D519N; 4:102597579-102597579	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.715G>A; p.A239T; 4:102579024-102579024	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2505T>C; p.T835T; 4:102612519-102612519	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1343A>G; p.D448G; 4:102596180-102596180	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1754C>T; p.T585M; 4:102606497-102606497	breast	carcinoma	Substitution - Missense
c.2516A>G; p.K839R; 4:102612530-102612530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.566T>G; p.L189R; 4:102577034-102577034	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2843C>T; p.S948L; 4:102616527-102616527	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1594G>A; p.V532I; 4:102597618-102597618	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1594G>A; p.V532I; 4:102597618-102597618	breast	carcinoma; luminal_NS_carcinoma	Substitution - Missense
c.1338T>C; p.G446G; 4:102596175-102596175	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.604C>A; p.L202M; 4:102578913-102578913	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2455C>T; p.Q819*; 4:102612469-102612469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1105C>T; p.P369S; 4:102593463-102593463	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1670C>T; p.S557F; 4:102600927-102600927	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1894C>T; p.L632F; 4:102606637-102606637	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1174_1176delGGC; p.G397delG; 4:102593532-102593534	skin; hip	malignant_melanoma	Deletion - In frame
c.1466G>T; p.G489V; 4:102596303-102596303	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1722C>T; p.D574D; 4:102600979-102600979	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.647T>G; p.M216R; 4:102578956-102578956	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.541G>T; p.A181S; 4:102577009-102577009	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.964A>G; p.I322V; 4:102584718-102584718	liver	carcinoma	Substitution - Missense
c.964A>G; p.I322V; 4:102584718-102584718	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.964A>G; p.I322V; 4:102584718-102584718	liver	carcinoma	Substitution - Missense
c.2043G>T; p.Q681H; 4:102607238-102607238	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2032G>A; p.V678I; 4:102607227-102607227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.221C>G; p.S74C; 4:102537919-102537919	breast	carcinoma	Substitution - Missense
c.774G>T; p.R258S; 4:102580578-102580578	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1674A>G; p.Q558Q; 4:102600931-102600931	liver	carcinoma	Substitution - coding silent
c.1214A>C; p.Y405S; 4:102594895-102594895	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.541G>C; p.A181P; 4:102577009-102577009	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.408-1G>T; p.?; 4:102576875-102576875	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.2504C>A; p.T835N; 4:102612518-102612518	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.809A>G; p.Y270C; 4:102580613-102580613	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.346G>T; p.G116*; 4:102567074-102567074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.877G>A; p.G293R; 4:102582907-102582907	pancreas	carcinoma	Substitution - Missense
c.312_313insA; p.N106fs*15; 4:102567040-102567041	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.2723C>T; p.S908L; 4:102613555-102613555	skin	malignant_melanoma	Substitution - Missense
c.2054C>T; p.S685F; 4:102607249-102607249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2148T>C; p.T716T; 4:102607672-102607672	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2190A>G; p.R730R; 4:102607714-102607714	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent

COSMIC somatic mutation [Top]