Entrez Gene

Basic Information
Gene ID	4692
Name	NDN
Synonymous	necdin, melanoma antigen (MAGE) family member;NDN;necdin, melanoma antigen (MAGE) family member
Definition	Prader-Willi syndrome chromosome region\|necdin\|necdin homolog
Position	15q11.2-q12
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.837G>T; p.L279L; 15:23686381-23686381	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.252C>T; p.S84S; 15:23686966-23686966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.424C>T; p.R142C; 15:23686794-23686794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.768C>A; p.P256P; 15:23686450-23686450	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.457C>A; p.L153M; 15:23686761-23686761	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.249G>T; p.P83P; 15:23686969-23686969	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.348G>T; p.K116N; 15:23686870-23686870	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.523G>A; p.E175K; 15:23686695-23686695	skin	malignant_melanoma	Substitution - Missense
c.663C>G; p.P221P; 15:23686555-23686555	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.48G>T; p.E16D; 15:23687170-23687170	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.325G>C; p.V109L; 15:23686893-23686893	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.195C>T; p.G65G; 15:23687023-23687023	pancreas	carcinoid-endocrine_tumour	Substitution - coding silent
c.20A>G; p.D7G; 15:23687198-23687198	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.698A>C; p.K233T; 15:23686520-23686520	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.851A>G; p.K284R; 15:23686367-23686367	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.851A>C; p.K284T; 15:23686367-23686367	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.654G>T; p.G218G; 15:23686564-23686564	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.684C>T; p.F228F; 15:23686534-23686534	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.851A>G; p.K284R; 15:23686367-23686367	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.284C>T; p.P95L; 15:23686934-23686934	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.284C>T; p.P95L; 15:23686934-23686934	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.392G>T; p.S131I; 15:23686826-23686826	liver	carcinoma	Substitution - Missense
c.392G>T; p.S131I; 15:23686826-23686826	liver	carcinoma	Substitution - Missense
c.780C>A; p.F260L; 15:23686438-23686438	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.784T>C; p.W262R; 15:23686434-23686434	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.563C>A; p.T188K; 15:23686655-23686655	liver	carcinoma	Substitution - Missense
c.563C>A; p.T188K; 15:23686655-23686655	liver	carcinoma	Substitution - Missense
c.88delG; p.E30fs*17; 15:23687130-23687130	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.425G>A; p.R142H; 15:23686793-23686793	breast	carcinoma	Substitution - Missense
c.357C>G; p.I119M; 15:23686861-23686861	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.357C>G; p.I119M; 15:23686861-23686861	urinary_tract; bladder	carcinoma	Substitution - Missense
c.533G>T; p.R178M; 15:23686685-23686685	pancreas	carcinoma	Substitution - Missense
c.609C>T; p.R203R; 15:23686609-23686609	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.609C>T; p.R203R; 15:23686609-23686609	liver	carcinoma	Substitution - coding silent
c.609C>T; p.R203R; 15:23686609-23686609	liver	carcinoma	Substitution - coding silent
c.624C>A; p.S208R; 15:23686594-23686594	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.603G>A; p.K201K; 15:23686615-23686615	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.551G>A; p.R184H; 15:23686667-23686667	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.685G>T; p.G229W; 15:23686533-23686533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626C>T; p.A209V; 15:23686592-23686592	large_intestine; colon	carcinoma	Substitution - Missense
c.803G>A; p.R268H; 15:23686415-23686415	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.659G>C; p.R220P; 15:23686559-23686559	skin	malignant_melanoma	Substitution - Missense
c.661C>A; p.P221T; 15:23686557-23686557	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.864G>A; p.Q288Q; 15:23686354-23686354	skin	malignant_melanoma	Substitution - coding silent
c.102G>A; p.P34P; 15:23687116-23687116	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.607C>T; p.R203C; 15:23686611-23686611	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.926C>T; p.P309L; 15:23686292-23686292	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.483C>T; p.H161H; 15:23686735-23686735	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.774C>T; p.Y258Y; 15:23686444-23686444	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.746G>A; p.R249H; 15:23686472-23686472	pancreas	carcinoma	Substitution - Missense
c.666G>A; p.W222*; 15:23686552-23686552	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.101C>T; p.P34L; 15:23687117-23687117	central_nervous_system; brain	glioma	Substitution - Missense
c.666G>A; p.W222*; 15:23686552-23686552	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.731A>G; p.Y244C; 15:23686487-23686487	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.555G>A; p.M185I; 15:23686663-23686663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.624C>T; p.S208S; 15:23686594-23686594	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.137T>C; p.L46P; 15:23687081-23687081	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.5C>G; p.S2*; 15:23687213-23687213	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.86C>T; p.S29L; 15:23687132-23687132	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.86C>T; p.S29L; 15:23687132-23687132	skin	malignant_melanoma	Substitution - Missense
c.829G>A; p.E277K; 15:23686389-23686389	skin	malignant_melanoma	Substitution - Missense
c.59C>T; p.S20F; 15:23687159-23687159	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.388G>A; p.G130S; 15:23686830-23686830	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.254C>T; p.A85V; 15:23686964-23686964	ovary	other; neoplasm	Substitution - Missense
c.300G>A; p.Q100Q; 15:23686918-23686918	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.927C>T; p.P309P; 15:23686291-23686291	skin	malignant_melanoma	Substitution - coding silent
c.107C>T; p.A36V; 15:23687111-23687111	central_nervous_system; brain	glioma	Substitution - Missense
c.769G>A; p.E257K; 15:23686449-23686449	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.534_535GG>AA; p.V179M; 15:23686683-23686684	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.960G>A; p.E320E; 15:23686258-23686258	skin	malignant_melanoma	Substitution - coding silent
c.825C>A; p.I275I; 15:23686393-23686393	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.608G>A; p.R203H; 15:23686610-23686610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.R203H; 15:23686610-23686610	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.R203H; 15:23686610-23686610	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.14G>T; p.S5I; 15:23687204-23687204	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.51C>A; p.A17A; 15:23687167-23687167	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.908C>T; p.A303V; 15:23686310-23686310	skin	malignant_melanoma	Substitution - Missense
c.222G>A; p.A74A; 15:23686996-23686996	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.825C>T; p.I275I; 15:23686393-23686393	skin	malignant_melanoma	Substitution - coding silent
c.726G>A; p.M242I; 15:23686492-23686492	skin	malignant_melanoma	Substitution - Missense
c.726G>A; p.M242I; 15:23686492-23686492	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.462C>T; p.H154H; 15:23686756-23686756	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.745C>T; p.R249C; 15:23686473-23686473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.745C>T; p.R249C; 15:23686473-23686473	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.805G>A; p.E269K; 15:23686413-23686413	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.805G>A; p.E269K; 15:23686413-23686413	skin; trunk	malignant_melanoma	Substitution - Missense
c.805G>A; p.E269K; 15:23686413-23686413	breast	carcinoma	Substitution - Missense
c.805G>A; p.E269K; 15:23686413-23686413	skin	malignant_melanoma	Substitution - Missense
c.923A>C; p.N308T; 15:23686295-23686295	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.621G>T; p.E207D; 15:23686597-23686597	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.288G>A; p.A96A; 15:23686930-23686930	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.241C>T; p.Q81*; 15:23686977-23686977	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Nonsense
c.828G>A; p.M276I; 15:23686390-23686390	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.828G>A; p.M276I; 15:23686390-23686390	skin	malignant_melanoma	Substitution - Missense
c.659G>A; p.R220Q; 15:23686559-23686559	large_intestine; colon	carcinoma	Substitution - Missense
c.828G>A; p.M276I; 15:23686390-23686390	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.913C>T; p.R305W; 15:23686305-23686305	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.271G>C; p.A91P; 15:23686947-23686947	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.121C>T; p.P41S; 15:23687097-23687097	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.427A>C; p.T143P; 15:23686791-23686791	urinary_tract; bladder	carcinoma	Substitution - Missense
c.517C>T; p.P173S; 15:23686701-23686701	ovary	other; neoplasm	Substitution - Missense
c.69C>T; p.H23H; 15:23687149-23687149	thyroid	carcinoma; anaplastic_carcinoma	Substitution - coding silent
c.69C>T; p.H23H; 15:23687149-23687149	thyroid	carcinoma; anaplastic_carcinoma	Substitution - coding silent
c.794G>A; p.R265Q; 15:23686424-23686424	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.614C>G; p.A205G; 15:23686604-23686604	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.765G>A; p.P255P; 15:23686453-23686453	breast	carcinoma	Substitution - coding silent
c.262C>A; p.P88T; 15:23686956-23686956	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.262C>A; p.P88T; 15:23686956-23686956	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.877C>G; p.R293G; 15:23686341-23686341	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.162C>T; p.A54A; 15:23687056-23687056	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.936C>T; p.H312H; 15:23686282-23686282	skin	malignant_melanoma	Substitution - coding silent
c.497C>T; p.A166V; 15:23686721-23686721	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.324C>A; p.Y108*; 15:23686894-23686894	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.297G>A; p.V99V; 15:23686921-23686921	breast	carcinoma	Substitution - coding silent
c.453C>T; p.F151F; 15:23686765-23686765	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.681C>T; p.T227T; 15:23686537-23686537	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.285G>A; p.P95P; 15:23686933-23686933	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.872C>A; p.P291H; 15:23686346-23686346	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.627C>T; p.A209A; 15:23686591-23686591	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.599T>A; p.V200E; 15:23686619-23686619	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.734T>C; p.L245P; 15:23686484-23686484	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.877C>T; p.R293*; 15:23686341-23686341	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.94delG; p.V32fs*15; 15:23687124-23687124	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.628G>A; p.V210I; 15:23686590-23686590	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.247C>T; p.P83S; 15:23686971-23686971	skin	malignant_melanoma	Substitution - Missense
c.717C>A; p.F239L; 15:23686501-23686501	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.105C>T; p.S35S; 15:23687113-23687113	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.619G>A; p.E207K; 15:23686599-23686599	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.63G>T; p.E21D; 15:23687155-23687155	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487A>G; p.M163V; 15:23686731-23686731	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.505A>G; p.K169E; 15:23686713-23686713	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.690C>T; p.D230D; 15:23686528-23686528	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.950G>A; p.S317N; 15:23686268-23686268	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.248C>T; p.P83L; 15:23686970-23686970	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.669G>A; p.K223K; 15:23686549-23686549	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.876C>T; p.S292S; 15:23686342-23686342	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.876C>T; p.S292S; 15:23686342-23686342	skin	malignant_melanoma	Substitution - coding silent
c.612C>T; p.G204G; 15:23686606-23686606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.796G>C; p.A266P; 15:23686422-23686422	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.875C>T; p.S292F; 15:23686343-23686343	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.375G>A; p.V125V; 15:23686843-23686843	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.251G>T; p.S84I; 15:23686967-23686967	ovary	other; neoplasm	Substitution - Missense
c.251G>T; p.S84I; 15:23686967-23686967	ovary	other; neoplasm	Substitution - Missense
c.874T>C; p.S292P; 15:23686344-23686344	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.389G>A; p.G130D; 15:23686829-23686829	large_intestine; colon	carcinoma	Substitution - Missense
c.102G>T; p.P34P; 15:23687116-23687116	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.510G>C; p.A170A; 15:23686708-23686708	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.625G>A; p.A209T; 15:23686593-23686593	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.566G>A; p.G189D; 15:23686652-23686652	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>A; p.A209T; 15:23686593-23686593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.21T>C; p.D7D; 15:23687197-23687197	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.717C>T; p.F239F; 15:23686501-23686501	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.717C>T; p.F239F; 15:23686501-23686501	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.717C>T; p.F239F; 15:23686501-23686501	skin	malignant_melanoma	Substitution - coding silent
c.717C>T; p.F239F; 15:23686501-23686501	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.246C>A; p.A82A; 15:23686972-23686972	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.253G>A; p.A85T; 15:23686965-23686965	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.309C>T; p.H103H; 15:23686909-23686909	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.309C>T; p.H103H; 15:23686909-23686909	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.108G>A; p.A36A; 15:23687110-23687110	skin	malignant_melanoma	Substitution - coding silent
c.858C>T; p.D286D; 15:23686360-23686360	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.88G>T; p.E30*; 15:23687130-23687130	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.523G>C; p.E175Q; 15:23686695-23686695	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.128G>A; p.S43N; 15:23687090-23687090	skin	malignant_melanoma	Substitution - Missense
c.616A>G; p.R206G; 15:23686602-23686602	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.249G>A; p.P83P; 15:23686969-23686969	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.509C>T; p.A170V; 15:23686709-23686709	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]