Entrez Gene

Basic Information
Gene ID	4478
Name	MSN
Synonymous	moesin;MSN;moesin
Definition	epididymis luminal protein 70\|membrane-organizing extension spike protein
Position	Xq11.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.897C>T; p.T299T; 23:65735368-65735368	skin	malignant_melanoma	Substitution - coding silent
c.519G>T; p.Q173H; 23:65731158-65731158	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.497A>G; p.D166G; 23:65731136-65731136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1050G>T; p.R350S; 23:65736885-65736885	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.445G>A; p.G149R; 23:65729690-65729690	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.480G>T; p.Q160H; 23:65731119-65731119	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1153G>A; p.E385K; 23:65737240-65737240	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.855G>A; p.M285I; 23:65735326-65735326	breast	carcinoma	Substitution - Missense
c.1649G>A; p.R550Q; 23:65739808-65739808	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1689G>A; p.R563R; 23:65739848-65739848	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1254C>A; p.A418A; 23:65738527-65738527	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.959G>A; p.R320H; 23:65735430-65735430	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1002G>A; p.E334E; 23:65736837-65736837	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.884G>A; p.R295H; 23:65735355-65735355	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1002G>A; p.E334E; 23:65736837-65736837	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1002G>A; p.E334E; 23:65736837-65736837	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1002G>A; p.E334E; 23:65736837-65736837	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1002G>A; p.E334E; 23:65736837-65736837	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1002G>A; p.E334E; 23:65736837-65736837	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1344G>T; p.K448N; 23:65738617-65738617	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1344G>T; p.K448N; 23:65738617-65738617	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.44A>G; p.E15G; 23:65716849-65716849	breast	carcinoma	Substitution - Missense
c.1555C>A; p.Q519K; 23:65739180-65739180	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.270C>T; p.S90S; 23:65729515-65729515	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.681C>A; p.I227I; 23:65731967-65731967	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.270C>T; p.S90S; 23:65729515-65729515	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.754G>A; p.D252N; 23:65733239-65733239	pancreas	carcinoma	Substitution - Missense
c.193-10C>T; p.?; 23:65729428-65729428	prostate	carcinoma	Unknown
c.1036_1038delGAG; p.E346delE; 23:65736871-65736873	soft_tissue; striated_muscle	rhabdomyosarcoma	Deletion - In frame
c.1734A>C; p.*578Y; 23:65739893-65739893	skin; head_neck	carcinoma; squamous_cell_carcinoma	Nonstop extension
c.1531G>T; p.E511*; 23:65739156-65739156	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Nonsense
c.1595C>A; p.A532D; 23:65739754-65739754	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1507C>T; p.R503C; 23:65739132-65739132	breast	carcinoma	Substitution - Missense
c.1031_1033delAGG; p.E346delE; 23:65736866-65736868	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1716C>G; p.D572E; 23:65739875-65739875	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.546G>A; p.M182I; 23:65731185-65731185	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>G; p.S249C; 23:65733231-65733231	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1441G>C; p.D481H; 23:65739066-65739066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1716C>T; p.D572D; 23:65739875-65739875	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.620G>A; p.S207N; 23:65731906-65731906	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1717G>A; p.E573K; 23:65739876-65739876	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1717G>A; p.E573K; 23:65739876-65739876	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1717G>A; p.E573K; 23:65739876-65739876	skin	malignant_melanoma	Substitution - Missense
c.1347C>T; p.A449A; 23:65738972-65738972	breast	carcinoma	Substitution - coding silent
c.1717G>A; p.E573K; 23:65739876-65739876	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.125T>C; p.V42A; 23:65727842-65727842	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.681C>T; p.I227I; 23:65731967-65731967	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.336T>C; p.N112N; 23:65729581-65729581	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.878G>A; p.R293H; 23:65735349-65735349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1001A>G; p.E334G; 23:65736836-65736836	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.118A>G; p.R40G; 23:65727835-65727835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.355C>A; p.P119T; 23:65729600-65729600	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1218C>G; p.A406A; 23:65737305-65737305	skin	malignant_melanoma	Substitution - coding silent
c.1421A>T; p.E474V; 23:65739046-65739046	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.269C>T; p.S90F; 23:65729514-65729514	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.807C>T; p.F269F; 23:65735278-65735278	skin	malignant_melanoma	Substitution - coding silent
c.1608C>T; p.S536S; 23:65739767-65739767	skin	malignant_melanoma	Substitution - coding silent
c.1679G>A; p.R560H; 23:65739838-65739838	ovary	carcinoma	Substitution - Missense
c.1189G>A; p.E397K; 23:65737276-65737276	breast	carcinoma	Substitution - Missense
c.1586T>A; p.L529Q; 23:65739745-65739745	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.335A>C; p.N112T; 23:65729580-65729580	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.539G>A; p.R180H; 23:65731178-65731178	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.22C>T; p.R8C; 23:65716827-65716827	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.12+2T>C; p.?; 23:65667855-65667855	stomach	carcinoma; adenocarcinoma	Unknown
c.22C>T; p.R8C; 23:65716827-65716827	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.885_886insA; p.P297fs*2; 23:65735356-65735357	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1656C>G; p.G552G; 23:65739815-65739815	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1678C>T; p.R560C; 23:65739837-65739837	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1678C>T; p.R560C; 23:65739837-65739837	breast	carcinoma	Substitution - Missense
c.1304G>T; p.R435L; 23:65738577-65738577	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.290T>C; p.I97T; 23:65729535-65729535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.196A>G; p.T66A; 23:65729441-65729441	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1046A>G; p.E349G; 23:65736881-65736881	skin; extremity	malignant_melanoma	Substitution - Missense
c.1046A>G; p.E349G; 23:65736881-65736881	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1046A>G; p.E349G; 23:65736881-65736881	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1046A>G; p.E349G; 23:65736881-65736881	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1541A>T; p.K514M; 23:65739166-65739166	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1468G>C; p.A490P; 23:65739093-65739093	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.242G>A; p.R81H; 23:65729487-65729487	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1636G>T; p.A546S; 23:65739795-65739795	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.554A>T; p.E185V; 23:65731840-65731840	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.554A>T; p.E185V; 23:65731840-65731840	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1231A>G; p.K411E; 23:65737318-65737318	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.193G>C; p.V65L; 23:65729438-65729438	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.264T>C; p.D88D; 23:65729509-65729509	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.877C>T; p.R293C; 23:65735348-65735348	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.263A>C; p.D88A; 23:65729508-65729508	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.540T>C; p.R180R; 23:65731179-65731179	ovary	other; neoplasm	Substitution - coding silent
c.856G>T; p.G286W; 23:65735327-65735327	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.589G>T; p.D197Y; 23:65731875-65731875	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1090+1G>T; p.?; 23:65736926-65736926	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.589G>T; p.D197Y; 23:65731875-65731875	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1465G>A; p.E489K; 23:65739090-65739090	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1183G>T; p.E395*; 23:65737270-65737270	pancreas	carcinoma	Substitution - Nonsense
c.361A>G; p.T121A; 23:65729606-65729606	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1137G>A; p.R379R; 23:65737224-65737224	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1508G>A; p.R503H; 23:65739133-65739133	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.425A>G; p.H142R; 23:65729670-65729670	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.801C>T; p.F267F; 23:65735272-65735272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.823C>T; p.R275W; 23:65735294-65735294	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.536A>G; p.H179R; 23:65731175-65731175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>T; p.V157F; 23:65731108-65731108	ovary	other; neoplasm	Substitution - Missense
c.23G>C; p.R8P; 23:65716828-65716828	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1681C>T; p.Q561*; 23:65739840-65739840	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1304G>A; p.R435Q; 23:65738577-65738577	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1135C>T; p.R379W; 23:65737222-65737222	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1156G>A; p.A386T; 23:65737243-65737243	skin	malignant_melanoma	Substitution - Missense
c.825G>A; p.R275R; 23:65735296-65735296	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.51G>T; p.E17D; 23:65716856-65716856	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.51G>T; p.E17D; 23:65716856-65716856	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1129C>T; p.Q377*; 23:65737216-65737216	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Nonsense
c.1600G>T; p.D534Y; 23:65739759-65739759	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.735C>T; p.I245I; 23:65733220-65733220	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1388T>A; p.L463Q; 23:65739013-65739013	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1671G>A; p.K557K; 23:65739830-65739830	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1258G>C; p.E420Q; 23:65738531-65738531	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1648C>T; p.R550*; 23:65739807-65739807	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.538C>T; p.R180C; 23:65731177-65731177	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1142G>A; p.R381H; 23:65737229-65737229	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.91G>C; p.D31H; 23:65716896-65716896	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1126G>C; p.E376Q; 23:65737213-65737213	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1126G>C; p.E376Q; 23:65737213-65737213	urinary_tract; bladder	carcinoma	Substitution - Missense
c.553G>T; p.E185*; 23:65731839-65731839	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1522C>T; p.R508C; 23:65739147-65739147	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1461_1466delGGCAGA; p.E489_A490del; 23:65739086-65739091	ovary	carcinoma; serous_carcinoma	Deletion - In frame
c.306C>T; p.F102F; 23:65729551-65729551	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.722C>T; p.P241L; 23:65733207-65733207	skin; extremity	malignant_melanoma	Substitution - Missense
c.157A>G; p.K53E; 23:65727874-65727874	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.416A>C; p.K139T; 23:65729661-65729661	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.262G>C; p.D88H; 23:65729507-65729507	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1108C>T; p.R370C; 23:65737195-65737195	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.845C>T; p.A282V; 23:65735316-65735316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1246C>G; p.Q416E; 23:65737333-65737333	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1183G>A; p.E395K; 23:65737270-65737270	skin	malignant_melanoma	Substitution - Missense
c.160G>A; p.G54S; 23:65727877-65727877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1122A>C; p.E374D; 23:65737209-65737209	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.429G>A; p.K143K; 23:65729674-65729674	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent

COSMIC somatic mutation [Top]