Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

4091

Name

SMAD6

Synonymous

SMAD family member 6;SMAD6;SMAD family member 6

Definition

MAD homolog 6|SMAD, mothers against DPP homolog 6|mothers against decapentaplegic homolog 6|mothers against decapentaplegic, drosophila, homolog of, 6

Position

15q22.31

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1390G>A; p.V464I; 15:66781434-66781434

 skinmalignant_melanomaSubstitution - Missense

c.1412G>A; p.G471D; 15:66781456-66781456

 skinmalignant_melanomaSubstitution - Missense

c.1051G>A; p.D351N; 15:66781095-66781095

 skinmalignant_melanomaSubstitution - Missense

c.363C>A; p.C121*; 15:66703621-66703621

 oesophaguscarcinoma; adenocarcinomaSubstitution - Nonsense

c.432C>T; p.P144P; 15:66703690-66703690

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1440C>T; p.F480F; 15:66781484-66781484

 skinmalignant_melanomaSubstitution - coding silent

c.863A>G; p.Y288C; 15:66711713-66711713

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.35G>A; p.R12Q; 15:66703293-66703293

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.35G>A; p.R12Q; 15:66703293-66703293

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; hairy_cell_leukaemiaSubstitution - Missense

c.1227C>T; p.P409P; 15:66781271-66781271

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1159A>T; p.I387F; 15:66781203-66781203

 central_nervous_system; braingliomaSubstitution - Missense

c.1306A>T; p.I436F; 15:66781350-66781350

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1439_1441delTCA; p.I481delI; 15:66781483-66781485

 pleurapulmonary_blastomaDeletion - In frame

c.1411G>A; p.G471S; 15:66781455-66781455

 skin; abdomenmalignant_melanomaSubstitution - Missense

c.1266C>T; p.G422G; 15:66781310-66781310

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1282C>T; p.R428C; 15:66781326-66781326

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1279G>A; p.V427M; 15:66781323-66781323

 breastcarcinomaSubstitution - Missense

c.826C>T; p.P276S; 15:66711676-66711676

 skinmalignant_melanomaSubstitution - Missense

c.826C>T; p.P276S; 15:66711676-66711676

 skinmalignant_melanomaSubstitution - Missense

c.1276G>T; p.V426F; 15:66781320-66781320

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.953-9G>T; p.?; 15:66780988-66780988

 oesophaguscarcinoma; adenocarcinomaUnknown

c.1318G>A; p.D440N; 15:66781362-66781362

 skinmalignant_melanomaSubstitution - Missense

c.1137G>A; p.S379S; 15:66781181-66781181

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1192G>A; p.D398N; 15:66781236-66781236

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.516C>G; p.L172L; 15:66703774-66703774

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.939G>C; p.P313P; 15:66716485-66716485

 livercarcinomaSubstitution - coding silent

c.1141C>A; p.R381R; 15:66781185-66781185

 oesophaguscarcinomaSubstitution - coding silent

c.1253A>T; p.D418V; 15:66781297-66781297

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1323C>T; p.F441F; 15:66781367-66781367

 skinmalignant_melanomaSubstitution - coding silent

c.1327C>T; p.R443C; 15:66781371-66781371

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1291delC; p.G433fs*>64; 15:66781335-66781335

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.1161C>T; p.I387I; 15:66781205-66781205

 skinmalignant_melanomaSubstitution - coding silent

c.833C>T; p.P278L; 15:66711683-66711683

 skinmalignant_melanomaSubstitution - Missense

c.1151G>A; p.R384H; 15:66781195-66781195

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1025G>A; p.R342H; 15:66781069-66781069

 breastcarcinomaSubstitution - Missense

c.1254C>T; p.D418D; 15:66781298-66781298

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1254C>T; p.D418D; 15:66781298-66781298

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1148C>T; p.T383M; 15:66781192-66781192

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.952+2T>C; p.?; 15:66716500-66716500

 stomachcarcinoma; adenocarcinomaUnknown

c.1297G>A; p.G433S; 15:66781341-66781341

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1433G>A; p.R478Q; 15:66781477-66781477

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1167C>T; p.F389F; 15:66781211-66781211

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1219G>A; p.E407K; 15:66781263-66781263

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1351G>A; p.E451K; 15:66781395-66781395

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.866A>T; p.K289M; 15:66711716-66711716

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.1393C>T; p.R465C; 15:66781437-66781437

 livercarcinomaSubstitution - Missense

c.1393C>T; p.R465C; 15:66781437-66781437

 livercarcinomaSubstitution - Missense

c.635A>C; p.D212A; 15:66703893-66703893

 pancreascarcinomaSubstitution - Missense

c.882C>A; p.S294S; 15:66716428-66716428

 pancreascarcinoid-endocrine_tumourSubstitution - coding silent

c.1261G>T; p.G421C; 15:66781305-66781305

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1278C>T; p.V426V; 15:66781322-66781322

 skinmalignant_melanomaSubstitution - coding silent

c.1430C>A; p.S477Y; 15:66781474-66781474

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1421C>T; p.P474L; 15:66781465-66781465

 skinmalignant_melanomaSubstitution - Missense

c.74_79delGCGGCA; p.S27_G28delSG; 15:66703332-66703337

 oesophaguscarcinoma; adenocarcinomaDeletion - In frame

c.1433G>T; p.R478L; 15:66781477-66781477

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

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