Entrez Gene

Basic Information
Gene ID	3620
Name	IDO1
Synonymous	indoleamine 2,3-dioxygenase 1;IDO1;indoleamine 2,3-dioxygenase 1
Definition	indolamine 2,3 dioxygenase\|indole 2,3-dioxygenase\|indoleamine-pyrrole 2,3-dioxygenase
Position	8p12-p11
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.142G>A; p.D48N; 8:39917929-39917929	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.868C>T; p.Q290*; 8:39927841-39927841	skin	malignant_melanoma	Substitution - Nonsense
c.1099A>G; p.T367A; 8:39928072-39928072	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1099A>G; p.T367A; 8:39928072-39928072	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.147C>T; p.L49L; 8:39917934-39917934	skin	malignant_melanoma	Substitution - coding silent
c.1107A>C; p.E369D; 8:39928080-39928080	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1081C>T; p.Q361*; 8:39928054-39928054	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.719A>G; p.N240S; 8:39925234-39925234	skin	malignant_melanoma	Substitution - Missense
c.986G>T; p.R329L; 8:39927959-39927959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10G>A; p.A4T; 8:39913932-39913932	breast	carcinoma	Substitution - Missense
c.621G>A; p.L207L; 8:39923552-39923552	skin	malignant_melanoma	Substitution - coding silent
c.1047C>T; p.I349I; 8:39928020-39928020	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.328C>T; p.P110S; 8:39918839-39918839	skin	malignant_melanoma	Substitution - Missense
c.437+1G>A; p.?; 8:39920115-39920115	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.579G>A; p.R193R; 8:39923510-39923510	skin	malignant_melanoma	Substitution - coding silent
c.9C>T; p.H3H; 8:39913931-39913931	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.384C>A; p.D128E; 8:39918895-39918895	pancreas	carcinoma	Substitution - Missense
c.474C>T; p.D158D; 8:39922588-39922588	skin	malignant_melanoma	Substitution - coding silent
c.1075A>G; p.S359G; 8:39928048-39928048	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.654C>T; p.H218H; 8:39923585-39923585	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.265G>A; p.A89T; 8:39918169-39918169	skin	malignant_melanoma	Substitution - Missense
c.401G>A; p.W134*; 8:39918912-39918912	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1175G>T; p.R392I; 8:39928148-39928148	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.361_363delCCT; p.P122delP; 8:39918872-39918874	liver	carcinoma; hepatocellular_carcinoma	Deletion - In frame
c.355G>A; p.E119K; 8:39918866-39918866	skin	malignant_melanoma	Substitution - Missense
c.807C>A; p.V269V; 8:39925322-39925322	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.299G>A; p.R100H; 8:39918203-39918203	thyroid	carcinoma	Substitution - Missense
c.469G>A; p.G157R; 8:39922583-39922583	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1101C>T; p.T367T; 8:39928074-39928074	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.507G>A; p.L169L; 8:39922621-39922621	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.229C>T; p.R77C; 8:39918133-39918133	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.815G>T; p.C272F; 8:39925330-39925330	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1193C>T; p.S398F; 8:39928166-39928166	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.544C>T; p.P182S; 8:39923475-39923475	skin	malignant_melanoma	Substitution - Missense
c.820G>A; p.D274N; 8:39925335-39925335	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.999C>T; p.D333D; 8:39927972-39927972	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.762A>G; p.E254E; 8:39925277-39925277	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.35G>A; p.S12N; 8:39913957-39913957	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.325G>T; p.V109F; 8:39918836-39918836	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.935C>G; p.S312*; 8:39927908-39927908	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.678T>C; p.F226F; 8:39924743-39924743	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1067T>C; p.I356T; 8:39928040-39928040	skin	malignant_melanoma	Substitution - Missense
c.364C>T; p.P122S; 8:39918875-39918875	skin	malignant_melanoma	Substitution - Missense
c.965C>G; p.S322*; 8:39927938-39927938	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.467A>G; p.D156G; 8:39922581-39922581	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1161C>T; p.F387F; 8:39928134-39928134	skin	malignant_melanoma	Substitution - coding silent
c.981C>T; p.G327G; 8:39927954-39927954	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1090G>A; p.E364K; 8:39928063-39928063	skin	malignant_melanoma	Substitution - Missense
c.1000G>A; p.A334T; 8:39927973-39927973	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.524C>A; p.A175D; 8:39922638-39922638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993T>G; p.A331A; 8:39927966-39927966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.328C>A; p.P110T; 8:39918839-39918839	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.856+2T>C; p.?; 8:39925373-39925373	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.459A>G; p.S153S; 8:39922573-39922573	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.463C>T; p.R155C; 8:39922577-39922577	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.805G>A; p.V269I; 8:39925320-39925320	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.463C>T; p.R155C; 8:39922577-39922577	skin	malignant_melanoma	Substitution - Missense
c.463C>T; p.R155C; 8:39922577-39922577	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1018G>C; p.V340L; 8:39927991-39927991	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.89A>G; p.E30G; 8:39917876-39917876	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.100G>A; p.D34N; 8:39917887-39917887	skin	malignant_melanoma	Substitution - Missense
c.534C>T; p.I178I; 8:39922648-39922648	skin	malignant_melanoma	Substitution - coding silent
c.772G>A; p.E258K; 8:39925287-39925287	skin	malignant_melanoma	Substitution - Missense
c.772G>A; p.E258K; 8:39925287-39925287	skin	malignant_melanoma	Substitution - Missense
c.577C>G; p.R193G; 8:39923508-39923508	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1122G>A; p.L374L; 8:39928095-39928095	skin	malignant_melanoma	Substitution - coding silent
c.250G>A; p.G84R; 8:39918154-39918154	skin	malignant_melanoma	Substitution - Missense
c.250G>A; p.G84R; 8:39918154-39918154	skin	malignant_melanoma	Substitution - Missense
c.998A>G; p.D333G; 8:39927971-39927971	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.184-1G>A; p.?; 8:39918087-39918087	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1159T>G; p.F387V; 8:39928132-39928132	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.919C>T; p.L307L; 8:39927892-39927892	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.717C>T; p.G239G; 8:39925232-39925232	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.485G>A; p.G162E; 8:39922599-39922599	skin	malignant_melanoma	Substitution - Missense
c.348G>T; p.K116N; 8:39918859-39918859	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.859C>T; p.H287Y; 8:39927832-39927832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.228G>T; p.Q76H; 8:39918132-39918132	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.228G>T; p.Q76H; 8:39918132-39918132	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.228G>T; p.Q76H; 8:39918132-39918132	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1154T>C; p.M385T; 8:39928127-39928127	liver	carcinoma	Substitution - Missense
c.1154T>C; p.M385T; 8:39928127-39928127	liver	carcinoma	Substitution - Missense
c.1101C>A; p.T367T; 8:39928074-39928074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.785G>A; p.G262D; 8:39925300-39925300	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.181A>G; p.K61E; 8:39917968-39917968	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.159C>T; p.G53G; 8:39917946-39917946	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.552A>G; p.V184V; 8:39923483-39923483	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.841C>T; p.Q281*; 8:39925356-39925356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.214G>A; p.D72N; 8:39918118-39918118	skin	malignant_melanoma	Substitution - Missense
c.766C>T; p.P256S; 8:39925281-39925281	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.691C>T; p.R231C; 8:39924756-39924756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.578G>A; p.R193Q; 8:39923509-39923509	liver	carcinoma	Substitution - Missense
c.578G>A; p.R193Q; 8:39923509-39923509	skin	malignant_melanoma	Substitution - Missense
c.578G>A; p.R193Q; 8:39923509-39923509	liver	carcinoma	Substitution - Missense
c.691C>T; p.R231C; 8:39924756-39924756	skin	malignant_melanoma	Substitution - Missense
c.510G>A; p.V170V; 8:39922624-39922624	skin	malignant_melanoma	Substitution - coding silent
c.1022C>T; p.S341F; 8:39927995-39927995	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.174A>T; p.R58S; 8:39917961-39917961	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.775T>A; p.F259I; 8:39925290-39925290	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.167G>T; p.R56L; 8:39917954-39917954	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.302A>T; p.K101M; 8:39918206-39918206	pancreas	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]