Entrez Gene

Basic Information
Gene ID	3579
Name	CXCR2
Synonymous	chemokine (C-X-C motif) receptor 2;CXCR2;chemokine (C-X-C motif) receptor 2
Definition	C-X-C chemokine receptor type 2\|CXC-R2\|CXCR-2\|CXCR2 gene for IL8 receptor type B\|GRO/MGSA receptor\|IL-8 receptor type 2\|IL-8R B\|chemokine (CXC) receptor 2\|high affinity interleukin-8 receptor B\|interleukin 8 receptor B\|interleukin 8 receptor type 2\|interl
Position	2q35
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.651C>T; p.S217S; 2:218135452-218135452	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.651C>T; p.S217S; 2:218135452-218135452	skin	malignant_melanoma	Substitution - coding silent
c.993A>G; p.I331M; 2:218135794-218135794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.865C>T; p.R289C; 2:218135666-218135666	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.721G>T; p.A241S; 2:218135522-218135522	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.279C>A; p.A93A; 2:218135080-218135080	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.234C>T; p.V78V; 2:218135035-218135035	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.876C>T; p.I292I; 2:218135677-218135677	skin	malignant_melanoma	Substitution - coding silent
c.689G>A; p.C230Y; 2:218135490-218135490	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.900G>A; p.E300E; 2:218135701-218135701	skin	malignant_melanoma	Substitution - coding silent
c.316G>A; p.A106T; 2:218135117-218135117	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.316G>A; p.A106T; 2:218135117-218135117	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.316G>A; p.A106T; 2:218135117-218135117	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.843G>A; p.V281V; 2:218135644-218135644	skin	malignant_melanoma	Substitution - coding silent
c.875_876TC>CT; p.I292T; 2:218135676-218135677	skin; mucosal	malignant_melanoma	Substitution - Missense
c.537T>A; p.P179P; 2:218135338-218135338	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.506T>G; p.I169S; 2:218135307-218135307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.293C>T; p.A98V; 2:218135094-218135094	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.787T>C; p.C263R; 2:218135588-218135588	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.862C>A; p.R288S; 2:218135663-218135663	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.710C>T; p.T237M; 2:218135511-218135511	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.883G>C; p.A295P; 2:218135684-218135684	central_nervous_system; brain	glioma	Substitution - Missense
c.584C>A; p.A195D; 2:218135385-218135385	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.378G>A; p.K126K; 2:218135179-218135179	skin	malignant_melanoma	Substitution - coding silent
c.492C>A; p.F164L; 2:218135293-218135293	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.567A>G; p.S189S; 2:218135368-218135368	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.678C>T; p.I226I; 2:218135479-218135479	skin	malignant_melanoma	Substitution - coding silent
c.239G>A; p.R80H; 2:218135040-218135040	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.239G>A; p.R80H; 2:218135040-218135040	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.239G>A; p.R80H; 2:218135040-218135040	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.239G>A; p.R80H; 2:218135040-218135040	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.113C>T; p.P38L; 2:218134914-218134914	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.113C>T; p.P38L; 2:218134914-218134914	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.279C>T; p.A93A; 2:218135080-218135080	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.578G>T; p.S193I; 2:218135379-218135379	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>A; p.V187I; 2:218135360-218135360	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>A; p.V187I; 2:218135360-218135360	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.390C>A; p.F130L; 2:218135191-218135191	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.328A>G; p.N110D; 2:218135129-218135129	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.786C>T; p.L262L; 2:218135587-218135587	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.786C>T; p.L262L; 2:218135587-218135587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.786C>T; p.L262L; 2:218135587-218135587	thyroid	other; neoplasm	Substitution - coding silent
c.4G>A; p.E2K; 2:218134805-218134805	skin	malignant_melanoma	Substitution - Missense
c.920G>T; p.S307I; 2:218135721-218135721	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.933C>T; p.P311P; 2:218135734-218135734	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.933C>T; p.P311P; 2:218135734-218135734	breast	carcinoma	Substitution - coding silent
c.147T>C; p.Y49Y; 2:218134948-218134948	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.668C>A; p.P223Q; 2:218135469-218135469	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>T; p.L68L; 2:218135005-218135005	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.109G>A; p.A37T; 2:218134910-218134910	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>T; p.L68L; 2:218135005-218135005	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.109G>A; p.A37T; 2:218134910-218134910	central_nervous_system; brain	glioma	Substitution - Missense
c.18G>A; p.M6I; 2:218134819-218134819	skin	malignant_melanoma	Substitution - Missense
c.18G>A; p.M6I; 2:218134819-218134819	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.280G>A; p.D94N; 2:218135081-218135081	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.694G>A; p.G232R; 2:218135495-218135495	central_nervous_system; brain	glioma	Substitution - Missense
c.971G>A; p.G324E; 2:218135772-218135772	skin	malignant_melanoma	Substitution - Missense
c.108C>T; p.A36A; 2:218134909-218134909	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.49G>A; p.G17S; 2:218134850-218134850	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.70A>G; p.S24G; 2:218134871-218134871	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.975C>T; p.L325L; 2:218135776-218135776	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.959A>C; p.K320T; 2:218135760-218135760	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.964C>T; p.R322C; 2:218135765-218135765	skin	malignant_melanoma	Substitution - Missense
c.964C>T; p.R322C; 2:218135765-218135765	skin	malignant_melanoma	Substitution - Missense
c.964C>T; p.R322C; 2:218135765-218135765	skin	malignant_melanoma	Substitution - Missense
c.964C>T; p.R322C; 2:218135765-218135765	skin	malignant_melanoma	Substitution - Missense
c.964C>T; p.R322C; 2:218135765-218135765	skin	malignant_melanoma	Substitution - Missense
c.964C>T; p.R322C; 2:218135765-218135765	skin	malignant_melanoma	Substitution - Missense
c.964C>T; p.R322C; 2:218135765-218135765	skin	malignant_melanoma	Substitution - Missense
c.981G>T; p.K327N; 2:218135782-218135782	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.610A>G; p.T204A; 2:218135411-218135411	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.610A>G; p.T204A; 2:218135411-218135411	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.624G>A; p.R208R; 2:218135425-218135425	skin	malignant_melanoma	Substitution - coding silent
c.744G>A; p.R248R; 2:218135545-218135545	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.862C>T; p.R288C; 2:218135663-218135663	pancreas	carcinoma	Substitution - Missense
c.862C>T; p.R288C; 2:218135663-218135663	urinary_tract; bladder	carcinoma	Substitution - Missense
c.661_662insT; p.V222fs*19; 2:218135462-218135463	liver	carcinoma	Insertion - Frameshift
c.707G>A; p.R236H; 2:218135508-218135508	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.451G>A; p.A151T; 2:218135252-218135252	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.707G>A; p.R236H; 2:218135508-218135508	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.898G>A; p.E300K; 2:218135699-218135699	skin	malignant_melanoma	Substitution - Missense
c.333C>A; p.G111G; 2:218135134-218135134	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.193G>A; p.G65R; 2:218134994-218134994	skin	malignant_melanoma	Substitution - Missense
c.235G>A; p.G79S; 2:218135036-218135036	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.236G>A; p.G79D; 2:218135037-218135037	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.570C>G; p.S190S; 2:218135371-218135371	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.486C>T; p.V162V; 2:218135287-218135287	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.346A>G; p.T116A; 2:218135147-218135147	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.57T>A; p.D19E; 2:218134858-218134858	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.315C>T; p.A105A; 2:218135116-218135116	breast	carcinoma; ER-PR-positive_carcinoma	Substitution - coding silent
c.17T>C; p.M6T; 2:218134818-218134818	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.118G>A; p.E40K; 2:218134919-218134919	skin	malignant_melanoma	Substitution - Missense
c.573T>C; p.N191N; 2:218135374-218135374	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.884C>T; p.A295V; 2:218135685-218135685	skin	malignant_melanoma	Substitution - Missense
c.884C>T; p.A295V; 2:218135685-218135685	skin	malignant_melanoma	Substitution - Missense
c.335G>A; p.W112*; 2:218135136-218135136	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Nonsense
c.313G>C; p.A105P; 2:218135114-218135114	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1040C>T; p.S347F; 2:218135841-218135841	skin	malignant_melanoma	Substitution - Missense
c.58C>A; p.L20I; 2:218134859-218134859	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.248C>T; p.T83I; 2:218135049-218135049	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1060G>T; p.G354W; 2:218135861-218135861	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.489A>C; p.K163N; 2:218135290-218135290	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.518C>T; p.S173F; 2:218135319-218135319	skin	malignant_melanoma	Substitution - Missense
c.201C>T; p.S67S; 2:218135002-218135002	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.931C>T; p.P311S; 2:218135732-218135732	skin	malignant_melanoma	Substitution - Missense
c.303G>C; p.L101F; 2:218135104-218135104	pancreas	carcinoma	Substitution - Missense
c.303G>C; p.L101F; 2:218135104-218135104	pancreas	carcinoma	Substitution - Missense
c.303G>C; p.L101F; 2:218135104-218135104	pancreas	carcinoma	Substitution - Missense
c.303G>C; p.L101F; 2:218135104-218135104	pancreas	carcinoma	Substitution - Missense
c.431G>A; p.R144H; 2:218135232-218135232	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1016C>T; p.S339F; 2:218135817-218135817	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.916C>T; p.H306Y; 2:218135717-218135717	skin	malignant_melanoma	Substitution - Missense
c.850G>A; p.E284K; 2:218135651-218135651	NS	malignant_melanoma	Substitution - Missense
c.985C>A; p.L329I; 2:218135786-218135786	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.850G>A; p.E284K; 2:218135651-218135651	NS	malignant_melanoma	Substitution - Missense
c.128C>T; p.S43F; 2:218134929-218134929	skin	malignant_melanoma	Substitution - Missense
c.622C>T; p.R208W; 2:218135423-218135423	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>T; p.R208W; 2:218135423-218135423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.422G>A; p.S141N; 2:218135223-218135223	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1063C>A; p.H355N; 2:218135864-218135864	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.106G>A; p.A36T; 2:218134907-218134907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.78C>A; p.S26R; 2:218134879-218134879	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.457C>T; p.R153C; 2:218135258-218135258	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>T; p.A255V; 2:218135565-218135565	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.764C>T; p.A255V; 2:218135565-218135565	skin	malignant_melanoma	Substitution - Missense
c.27C>T; p.D9D; 2:218134828-218134828	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.754G>T; p.V252F; 2:218135555-218135555	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.319T>A; p.S107T; 2:218135120-218135120	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.856T>C; p.C286R; 2:218135657-218135657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.137T>C; p.I46T; 2:218134938-218134938	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense

COSMIC somatic mutation [Top]