Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

3486

Name

IGFBP3

Synonymous

insulin-like growth factor binding protein 3;IGFBP3;insulin-like growth factor binding protein 3

Definition

IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3

Position

7p12.3

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.754C>T; p.R252C; 7:45914942-45914942

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.754C>T; p.R252C; 7:45914942-45914942

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.839A>T; p.K280M; 7:45914857-45914857

 prostatecarcinomaSubstitution - Missense

c.839A>T; p.K280M; 7:45914857-45914857

 prostatecarcinomaSubstitution - Missense

c.712C>A; p.P238T; 7:45916586-45916586

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.641G>A; p.R214H; 7:45916657-45916657

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.570C>T; p.Y190Y; 7:45917273-45917273

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.570C>T; p.Y190Y; 7:45917273-45917273

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.471G>A; p.T157T; 7:45917372-45917372

 breastcarcinomaSubstitution - coding silent

c.619G>C; p.E207Q; 7:45917224-45917224

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.752G>A; p.C251Y; 7:45914944-45914944

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.554G>A; p.R185H; 7:45917289-45917289

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.646G>T; p.E216*; 7:45916652-45916652

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.869G>A; p.S290N; 7:45914827-45914827

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.615G>A; p.K205K; 7:45917228-45917228

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.617G>A; p.R206Q; 7:45917226-45917226

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.766G>T; p.G256C; 7:45914930-45914930

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.436G>A; p.A146T; 7:45917407-45917407

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.773A>C; p.K258T; 7:45914923-45914923

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.470C>A; p.T157K; 7:45917373-45917373

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.683A>G; p.N228S; 7:45916615-45916615

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.265G>T; p.G89C; 7:45920876-45920876

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.438C>A; p.A146A; 7:45917405-45917405

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.797A>G; p.D266G; 7:45914899-45914899

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.419C>T; p.S140L; 7:45917424-45917424

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.419C>T; p.S140L; 7:45917424-45917424

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.605C>T; p.S202F; 7:45917238-45917238

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.755G>A; p.R252H; 7:45914941-45914941

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.755G>A; p.R252H; 7:45914941-45914941

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.867G>T; p.Q289H; 7:45914829-45914829

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.473A>C; p.H158P; 7:45917370-45917370

 thyroidother; neoplasmSubstitution - Missense

c.473A>C; p.H158P; 7:45917370-45917370

 thyroidother; neoplasmSubstitution - Missense

c.419C>A; p.S140*; 7:45917424-45917424

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.746A>T; p.K249M; 7:45916552-45916552

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.439G>A; p.G147S; 7:45917404-45917404

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.521T>G; p.I174S; 7:45917322-45917322

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.717C>T; p.N239N; 7:45916581-45916581

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.404-1G>C; p.?; 7:45917440-45917440

 kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.423G>A; p.E141E; 7:45917420-45917420

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.431G>A; p.R144H; 7:45917412-45917412

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.864G>A; p.M288I; 7:45914832-45914832

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.800A>C; p.K267T; 7:45914896-45914896

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.20C>T; p.T7M; 7:45921121-45921121

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.28G>T; p.A10S; 7:45921113-45921113

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.600C>A; p.F200L; 7:45917243-45917243

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.685G>A; p.V229M; 7:45916613-45916613

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.739A>G; p.K247E; 7:45916559-45916559

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.95C>G; p.A32G; 7:45921046-45921046

 thyroidother; neoplasmSubstitution - Missense

c.606C>T; p.S202S; 7:45917237-45917237

 prostatecarcinomaSubstitution - coding silent

c.499C>T; p.P167S; 7:45917344-45917344

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.499C>T; p.P167S; 7:45917344-45917344

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.475C>T; p.R159W; 7:45917368-45917368

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.404G>A; p.G135E; 7:45917439-45917439

 skinmalignant_melanomaSubstitution - Missense

c.757C>T; p.P253S; 7:45914939-45914939

 skinmalignant_melanomaSubstitution - Missense

c.553C>T; p.R185C; 7:45917290-45917290

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.430C>T; p.R144C; 7:45917413-45917413

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.553C>T; p.R185C; 7:45917290-45917290

 pancreascarcinomaSubstitution - Missense

c.553C>T; p.R185C; 7:45917290-45917290

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.553C>T; p.R185C; 7:45917290-45917290

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.504C>G; p.L168L; 7:45917339-45917339

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.497A>G; p.H166R; 7:45917346-45917346

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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