Entrez Gene

Basic Information
Gene ID	3428
Name	IFI16
Synonymous	interferon, gamma-inducible protein 16;IFI16;interferon, gamma-inducible protein 16
Definition	gamma-interferon-inducible protein 16\|interferon-gamma induced protein IFI 16\|interferon-inducible myeloid differentiation transcriptional activator
Position	1q22
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1190A>G; p.N397S; 1:159032552-159032552	breast	carcinoma	Substitution - Missense
c.1838C>T; p.A613V; 1:159052019-159052019	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.878A>C; p.K293T; 1:159018557-159018557	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1725C>G; p.A575A; 1:159051906-159051906	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.387_388insA; p.S132fs*12; 1:159016538-159016539	central_nervous_system; brainstem	glioma; astrocytoma_Grade_IV	Insertion - Frameshift
c.1675G>A; p.V559I; 1:159051856-159051856	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.661C>G; p.P221A; 1:159018340-159018340	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.247delA; p.E85fs*3; 1:159014927-159014927	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1435G>A; p.E479K; 1:159045402-159045402	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1600G>T; p.V534L; 1:159051781-159051781	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1843G>A; p.V615I; 1:159052024-159052024	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1449C>A; p.H483Q; 1:159045416-159045416	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.590G>A; p.R197K; 1:159018269-159018269	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1225C>A; p.R409S; 1:159032587-159032587	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.394T>C; p.S132P; 1:159016545-159016545	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.919C>G; p.L307V; 1:159018598-159018598	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.92A>C; p.N31T; 1:159014772-159014772	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.287G>T; p.R96I; 1:159015893-159015893	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1044A>C; p.T348T; 1:159020412-159020412	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.510G>T; p.K170N; 1:159016661-159016661	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1103G>A; p.R368Q; 1:159020471-159020471	thyroid	carcinoma	Substitution - Missense
c.1320C>A; p.F440L; 1:159032682-159032682	prostate	carcinoma	Substitution - Missense
c.146C>T; p.A49V; 1:159014826-159014826	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1735_1736delTA; p.Y579fs*17; 1:159051916-159051917	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Deletion - Frameshift
c.1167_1168insA; p.T392fs*7; 1:159032529-159032530	pancreas	carcinoma; ductal_carcinoma	Insertion - Frameshift
c.967C>T; p.H323Y; 1:159018646-159018646	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2074G>T; p.G692W; 1:159053689-159053689	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.599T>C; p.L200P; 1:159018278-159018278	liver	carcinoma	Substitution - Missense
c.717C>A; p.F239L; 1:159018396-159018396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1245A>G; p.S415S; 1:159032607-159032607	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.315T>C; p.T105T; 1:159015921-159015921	breast	carcinoma	Substitution - coding silent
c.1656T>C; p.N552N; 1:159051837-159051837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1168A>T; p.K390*; 1:159032530-159032530	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2084G>C; p.R695T; 1:159053699-159053699	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1003G>A; p.E335K; 1:159020371-159020371	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1134G>T; p.L378L; 1:159020502-159020502	liver	carcinoma	Substitution - coding silent
c.1022G>A; p.G341E; 1:159020390-159020390	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.633T>A; p.S211R; 1:159018312-159018312	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.114A>T; p.K38N; 1:159014794-159014794	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2037C>T; p.L679L; 1:159053652-159053652	skin	malignant_melanoma	Substitution - coding silent
c.68G>A; p.R23K; 1:159014748-159014748	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.46G>T; p.V16F; 1:159014726-159014726	breast	carcinoma	Substitution - Missense
c.572G>A; p.C191Y; 1:159018251-159018251	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.986A>G; p.Q329R; 1:159020354-159020354	liver	carcinoma	Substitution - Missense
c.1458G>T; p.Q486H; 1:159045425-159045425	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.986A>G; p.Q329R; 1:159020354-159020354	liver	carcinoma	Substitution - Missense
c.1822G>T; p.G608*; 1:159052003-159052003	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.919C>A; p.L307I; 1:159018598-159018598	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.45G>T; p.E15D; 1:159014725-159014725	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.814G>A; p.E272K; 1:159018493-159018493	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2067G>A; p.G689G; 1:159053682-159053682	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.361G>C; p.E121Q; 1:159015967-159015967	urinary_tract; bladder	carcinoma	Substitution - Missense
c.913G>A; p.D305N; 1:159018592-159018592	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.526C>T; p.P176S; 1:159016677-159016677	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1802G>A; p.R601Q; 1:159051983-159051983	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2109+6A>T; p.?; 1:159053730-159053730	liver	carcinoma	Unknown
c.376G>T; p.A126S; 1:159015982-159015982	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1475C>A; p.P492Q; 1:159045442-159045442	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.376G>T; p.A126S; 1:159015982-159015982	liver	carcinoma	Substitution - Missense
c.2109+6A>T; p.?; 1:159053730-159053730	liver	carcinoma	Unknown
c.1475C>A; p.P492Q; 1:159045442-159045442	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1661T>C; p.V554A; 1:159051842-159051842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1554G>A; p.Q518Q; 1:159051735-159051735	breast	carcinoma	Substitution - coding silent
c.1554G>A; p.Q518Q; 1:159051735-159051735	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1210C>G; p.L404V; 1:159032572-159032572	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1994_1999delGACTGA; p.R665_T667>P; 1:159053609-159053614	prostate	carcinoma	Complex - deletion inframe
c.658A>G; p.T220A; 1:159018337-159018337	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.211G>A; p.D71N; 1:159014891-159014891	pancreas	carcinoma	Substitution - Missense
c.6delA; p.K4fs*8; 1:159014686-159014686	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1061delT; p.I354fs*25; 1:159020429-159020429	central_nervous_system; brain	glioma	Deletion - Frameshift
c.1885A>C; p.S629R; 1:159052066-159052066	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.6delA; p.K4fs*8; 1:159014686-159014686	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.785C>T; p.S262L; 1:159018464-159018464	central_nervous_system; brain	glioma	Substitution - Missense
c.1954C>G; p.Q652E; 1:159053569-159053569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.897G>A; p.K299K; 1:159018576-159018576	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.575A>C; p.Q192P; 1:159018254-159018254	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1209G>C; p.K403N; 1:159032571-159032571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2167A>T; p.T723S; 1:159054878-159054878	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.435C>T; p.S145S; 1:159016586-159016586	oesophagus	carcinoma	Substitution - coding silent
c.1086C>T; p.L362L; 1:159020454-159020454	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1518_1519TG>CT; p.E507*; 1:159051699-159051700	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.268A>C; p.K90Q; 1:159015874-159015874	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1099T>G; p.F367V; 1:159020467-159020467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.362A>G; p.E121G; 1:159015968-159015968	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1872A>G; p.S624S; 1:159052053-159052053	breast	carcinoma	Substitution - coding silent
c.620T>C; p.V207A; 1:159018299-159018299	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.885C>T; p.I295I; 1:159018564-159018564	skin	malignant_melanoma	Substitution - coding silent
c.346A>C; p.K116Q; 1:159015952-159015952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1489T>G; p.L497V; 1:159045456-159045456	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2009A>C; p.N670T; 1:159053624-159053624	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.265G>C; p.V89L; 1:159014945-159014945	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1154T>G; p.F385C; 1:159020522-159020522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.100A>T; p.K34*; 1:159014780-159014780	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.606A>G; p.K202K; 1:159018285-159018285	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2115C>G; p.I705M; 1:159054826-159054826	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.478T>A; p.S160T; 1:159016629-159016629	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1214C>T; p.P405L; 1:159032576-159032576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1102C>T; p.R368*; 1:159020470-159020470	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.717C>T; p.F239F; 1:159018396-159018396	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1623G>T; p.K541N; 1:159051804-159051804	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1921A>C; p.N641H; 1:159053536-159053536	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.539C>A; p.S180Y; 1:159016690-159016690	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1339G>T; p.D447Y; 1:159045306-159045306	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.427A>T; p.K143*; 1:159016578-159016578	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.1745G>A; p.R582H; 1:159051926-159051926	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.672_673insA; p.I227fs*42; 1:159018351-159018352	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1745G>A; p.R582H; 1:159051926-159051926	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.94G>A; p.D32N; 1:159014774-159014774	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1669G>C; p.V557L; 1:159051850-159051850	breast	carcinoma	Substitution - Missense
c.417C>A; p.P139P; 1:159016568-159016568	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.952G>T; p.G318W; 1:159018631-159018631	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1277T>G; p.L426R; 1:159032639-159032639	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1277T>G; p.L426R; 1:159032639-159032639	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1089A>G; p.Q363Q; 1:159020457-159020457	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1089A>G; p.Q363Q; 1:159020457-159020457	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1277T>G; p.L426R; 1:159032639-159032639	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1089A>G; p.Q363Q; 1:159020457-159020457	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2014G>T; p.E672*; 1:159053629-159053629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1240C>A; p.P414T; 1:159032602-159032602	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.246_247insA; p.E85fs*34; 1:159014926-159014927	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.982A>T; p.N328Y; 1:159020350-159020350	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>A; p.E70K; 1:159014888-159014888	large_intestine; caecum	adenoma	Substitution - Missense
c.618A>G; p.I206M; 1:159018297-159018297	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.62A>T; p.H21L; 1:159014742-159014742	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.291G>C; p.K97N; 1:159015897-159015897	breast	carcinoma	Substitution - Missense
c.611C>A; p.P204Q; 1:159018290-159018290	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1450A>C; p.T484P; 1:159045417-159045417	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2058G>A; p.P686P; 1:159053673-159053673	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1345A>C; p.I449L; 1:159045312-159045312	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1237T>A; p.Y413N; 1:159032599-159032599	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1530A>C; p.E510D; 1:159051711-159051711	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1530A>C; p.E510D; 1:159051711-159051711	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1530A>C; p.E510D; 1:159051711-159051711	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1209G>A; p.K403K; 1:159032571-159032571	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1842C>T; p.S614S; 1:159052023-159052023	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1310C>T; p.S437F; 1:159032672-159032672	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1873C>A; p.Q625K; 1:159052054-159052054	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1345A>G; p.I449V; 1:159045312-159045312	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.673_674insA; p.I227fs*42; 1:159018352-159018353	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.1801C>T; p.R601*; 1:159051982-159051982	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1801C>T; p.R601*; 1:159051982-159051982	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1786G>A; p.D596N; 1:159051967-159051967	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.471C>G; p.A157A; 1:159016622-159016622	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.392A>C; p.K131T; 1:159016543-159016543	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1253G>A; p.S418N; 1:159032615-159032615	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2052G>T; p.L684F; 1:159053667-159053667	liver	carcinoma	Substitution - Missense
c.2052G>T; p.L684F; 1:159053667-159053667	liver	carcinoma	Substitution - Missense
c.2082G>C; p.L694F; 1:159053697-159053697	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1928G>T; p.R643M; 1:159053543-159053543	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1585G>A; p.A529T; 1:159051766-159051766	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1673A>T; p.K558M; 1:159051854-159051854	breast	carcinoma	Substitution - Missense
c.1585G>A; p.A529T; 1:159051766-159051766	pancreas	carcinoma	Substitution - Missense
c.1585G>A; p.A529T; 1:159051766-159051766	pancreas	carcinoma	Substitution - Missense
c.1585G>A; p.A529T; 1:159051766-159051766	pancreas	carcinoma	Substitution - Missense
c.1256C>A; p.T419K; 1:159032618-159032618	liver	carcinoma	Substitution - Missense
c.1256C>A; p.T419K; 1:159032618-159032618	liver	carcinoma	Substitution - Missense
c.409G>T; p.A137S; 1:159016560-159016560	prostate	carcinoma	Substitution - Missense
c.528A>C; p.P176P; 1:159016679-159016679	breast	carcinoma	Substitution - coding silent
c.830C>A; p.S277Y; 1:159018509-159018509	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1406G>A; p.G469E; 1:159045373-159045373	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.211G>T; p.D71Y; 1:159014891-159014891	breast	carcinoma	Substitution - Missense
c.207C>T; p.F69F; 1:159014887-159014887	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1050A>G; p.Q350Q; 1:159020418-159020418	breast	carcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]