Entrez Gene

Basic Information
Gene ID	3313
Name	HSPA9
Synonymous	heat shock 70kDa protein 9 (mortalin);HSPA9;heat shock 70kDa protein 9 (mortalin)
Definition	75 kDa glucose-regulated protein\|catecholamine-regulated protein 40\|epididymis secretory sperm binding protein Li 124m\|heat shock 70kD protein 9B\|mortalin, perinuclear\|mortalin-2\|p66-mortalin\|peptide-binding protein 74\|stress-70 protein, mitochondrial
Position	5q31.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1378A>C; p.R460R; 5:138559896-138559896	liver	carcinoma	Substitution - coding silent
c.1378A>C; p.R460R; 5:138559896-138559896	liver	carcinoma	Substitution - coding silent
c.715G>T; p.V239F; 5:138567456-138567456	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.842C>T; p.A281V; 5:138567038-138567038	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.324G>A; p.Q108Q; 5:138571046-138571046	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1698G>T; p.E566D; 5:138557432-138557432	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1805A>C; p.Q602P; 5:138556790-138556790	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.644A>G; p.N215S; 5:138567527-138567527	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1822-8T>G; p.?; 5:138556600-138556600	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1407C>T; p.S469S; 5:138559867-138559867	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.369C>T; p.L123L; 5:138571001-138571001	skin	malignant_melanoma	Substitution - coding silent
c.1956C>T; p.Y652Y; 5:138556458-138556458	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.385G>A; p.D129N; 5:138570985-138570985	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.802A>C; p.N268H; 5:138567078-138567078	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1196T>C; p.V399A; 5:138560078-138560078	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1387A>G; p.T463A; 5:138559887-138559887	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.143C>G; p.S48*; 5:138573848-138573848	breast	carcinoma	Substitution - Nonsense
c.1144G>T; p.E382*; 5:138561618-138561618	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.557C>A; p.A186E; 5:138567701-138567701	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.701A>C; p.K234T; 5:138567470-138567470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.857T>C; p.I286T; 5:138567023-138567023	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1287C>T; p.A429A; 5:138559987-138559987	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1287C>T; p.A429A; 5:138559987-138559987	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1287C>T; p.A429A; 5:138559987-138559987	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.898A>T; p.K300*; 5:138566700-138566700	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1365C>A; p.T455T; 5:138559909-138559909	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1944C>T; p.F648F; 5:138556470-138556470	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1738G>T; p.E580*; 5:138556857-138556857	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.135T>G; p.D45E; 5:138574073-138574073	liver	carcinoma	Substitution - Missense
c.135T>G; p.D45E; 5:138574073-138574073	liver	carcinoma	Substitution - Missense
c.1300G>A; p.D434N; 5:138559974-138559974	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.932C>G; p.A311G; 5:138566666-138566666	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.766G>T; p.E256*; 5:138567114-138567114	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.245A>C; p.E82A; 5:138571125-138571125	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1373T>C; p.I458T; 5:138559901-138559901	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1373T>C; p.I458T; 5:138559901-138559901	urinary_tract; bladder	carcinoma	Substitution - Missense
c.464A>G; p.E155G; 5:138568996-138568996	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1019A>C; p.K340T; 5:138561743-138561743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.563_564insA; p.N188fs*12; 5:138567694-138567695	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1918C>G; p.L640V; 5:138556496-138556496	breast	carcinoma	Substitution - Missense
c.1532C>A; p.A511D; 5:138557970-138557970	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1440G>A; p.T480T; 5:138558628-138558628	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1440G>A; p.T480T; 5:138558628-138558628	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.379C>T; p.R127*; 5:138570991-138570991	central_nervous_system; brain	glioma	Substitution - Nonsense
c.1440G>A; p.T480T; 5:138558628-138558628	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.546G>A; p.L182L; 5:138567712-138567712	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.850C>T; p.R284W; 5:138567030-138567030	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.850C>T; p.R284W; 5:138567030-138567030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.600G>A; p.S200S; 5:138567658-138567658	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.611C>A; p.A204D; 5:138567560-138567560	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.591C>A; p.F197L; 5:138567667-138567667	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.69C>T; p.A23A; 5:138575250-138575250	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.389A>G; p.D130G; 5:138570981-138570981	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1496T>A; p.L499H; 5:138558572-138558572	liver	carcinoma	Substitution - Missense
c.706G>A; p.E236K; 5:138567465-138567465	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.140+1G>A; p.?; 5:138574067-138574067	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.247G>A; p.G83S; 5:138571123-138571123	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1634-7A>G; p.?; 5:138557503-138557503	kidney	other; neoplasm	Unknown
c.899A>C; p.K300T; 5:138566699-138566699	liver	carcinoma	Substitution - Missense
c.949T>C; p.C317R; 5:138566649-138566649	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.766G>A; p.E256K; 5:138567114-138567114	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.465G>A; p.E155E; 5:138568995-138568995	breast	carcinoma	Substitution - coding silent
c.250G>T; p.A84S; 5:138571120-138571120	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1969T>C; p.S657P; 5:138556108-138556108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1665A>C; p.K555N; 5:138557465-138557465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.317A>T; p.K106M; 5:138571053-138571053	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.813C>T; p.T271T; 5:138567067-138567067	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1779A>G; p.E593E; 5:138556816-138556816	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1174A>G; p.M392V; 5:138561588-138561588	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.962C>T; p.S321L; 5:138566636-138566636	breast	carcinoma	Substitution - Missense
c.1288G>A; p.G430S; 5:138559986-138559986	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1601C>G; p.A534G; 5:138557901-138557901	skin	malignant_melanoma	Substitution - Missense
c.1516-1G>T; p.?; 5:138557987-138557987	prostate	carcinoma; adenocarcinoma	Unknown
c.1516-1G>C; p.?; 5:138557987-138557987	breast	carcinoma	Unknown
c.1945G>A; p.E649K; 5:138556469-138556469	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.151A>G; p.I51V; 5:138573840-138573840	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.355G>A; p.A119T; 5:138571015-138571015	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1029T>C; p.N343N; 5:138561733-138561733	pancreas	carcinoma	Substitution - coding silent
c.1848C>A; p.S616S; 5:138556566-138556566	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.948A>G; p.K316K; 5:138566650-138566650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.261C>T; p.T87T; 5:138571109-138571109	skin	malignant_melanoma	Substitution - coding silent
c.1933C>T; p.L645L; 5:138556481-138556481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1933C>T; p.L645L; 5:138556481-138556481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.469C>T; p.H157Y; 5:138568991-138568991	pancreas	carcinoma	Substitution - Missense
c.1592A>G; p.H531R; 5:138557910-138557910	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.988C>T; p.P330S; 5:138561774-138561774	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1528C>T; p.P510S; 5:138557974-138557974	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1916C>T; p.S639F; 5:138556498-138556498	large_intestine; colon	carcinoma	Substitution - Missense
c.1916C>T; p.S639F; 5:138556498-138556498	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1916C>T; p.S639F; 5:138556498-138556498	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.108G>C; p.E36D; 5:138574100-138574100	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.918G>C; p.Q306H; 5:138566680-138566680	urinary_tract; bladder	carcinoma	Substitution - Missense
c.32G>T; p.R11L; 5:138575287-138575287	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]