Entrez Gene

Basic Information
Gene ID	3170
Name	FOXA2
Synonymous	forkhead box A2;FOXA2;forkhead box A2
Definition	HNF-3-beta\|HNF-3B\|TCF-3B\|forkhead box protein A2\|hepatic nuclear factor-3-beta\|hepatocyte nuclear factor 3, beta\|hepatocyte nuclear factor 3-beta\|transcription factor 3B
Position	20p11
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.326G>A; p.S109N; 20:22582898-22582898	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.457C>T; p.R153C; 20:22582767-22582767	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>C; p.Q174H; 20:22582702-22582702	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1045C>T; p.L349L; 20:22582179-22582179	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.837A>G; p.G279G; 20:22582387-22582387	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.837A>G; p.G279G; 20:22582387-22582387	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1148C>T; p.S383F; 20:22582076-22582076	skin	malignant_melanoma	Substitution - Missense
c.669G>A; p.S223S; 20:22582555-22582555	pancreas	carcinoma	Substitution - coding silent
c.616T>C; p.S206P; 20:22582608-22582608	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1185C>G; p.H395Q; 20:22582039-22582039	central_nervous_system; brain	glioma	Substitution - Missense
c.400A>C; p.S134R; 20:22582824-22582824	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.157A>G; p.S53G; 20:22583067-22583067	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1104_1105insAC; p.H369fs*41; 20:22582119-22582120	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.25G>A; p.G9R; 20:22584236-22584236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1272G>A; p.M424I; 20:22581952-22581952	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1023_1024delGC; p.Q342fs*19; 20:22582200-22582201	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.730G>A; p.E244K; 20:22582494-22582494	skin	malignant_melanoma	Substitution - Missense
c.743A>C; p.Y248S; 20:22582481-22582481	urinary_tract; bladder	carcinoma	Substitution - Missense
c.132G>A; p.M44I; 20:22583092-22583092	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.585C>T; p.F195F; 20:22582639-22582639	skin	malignant_melanoma	Substitution - coding silent
c.1292C>A; p.T431K; 20:22581932-22581932	ovary	other; neoplasm	Substitution - Missense
c.651C>A; p.F217L; 20:22582573-22582573	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.219G>A; p.M73I; 20:22583005-22583005	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1135A>G; p.N379D; 20:22582089-22582089	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.234G>T; p.A78A; 20:22582990-22582990	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1247C>T; p.S416F; 20:22581977-22581977	skin	malignant_melanoma	Substitution - Missense
c.990G>A; p.L330L; 20:22582234-22582234	breast	carcinoma	Substitution - coding silent
c.485A>G; p.Y162C; 20:22582739-22582739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.335C>T; p.P112L; 20:22582889-22582889	skin	malignant_melanoma	Substitution - Missense
c.1368C>A; p.S456S; 20:22581856-22581856	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.342G>T; p.G114G; 20:22582882-22582882	kidney	other; neoplasm	Substitution - coding silent
c.1308G>A; p.S436S; 20:22581916-22581916	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.112A>C; p.N38H; 20:22583112-22583112	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1174C>T; p.H392Y; 20:22582050-22582050	skin	malignant_melanoma	Substitution - Missense
c.390G>A; p.M130I; 20:22582834-22582834	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.669delG; p.D225fs*39; 20:22582555-22582555	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.625C>T; p.H209Y; 20:22582599-22582599	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>T; p.A158S; 20:22582752-22582752	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.519G>T; p.Q173H; 20:22582705-22582705	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1143C>T; p.L381L; 20:22582081-22582081	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.697T>A; p.W233R; 20:22582527-22582527	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.855T>A; p.A285A; 20:22582369-22582369	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.460_481del22; p.S154fs*20; 20:22582743-22582764	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.730G>T; p.E244*; 20:22582494-22582494	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.154G>A; p.G52S; 20:22583070-22583070	skin	malignant_melanoma	Substitution - Missense
c.1205T>A; p.L402H; 20:22582019-22582019	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.267C>T; p.G89G; 20:22582957-22582957	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1143C>A; p.L381L; 20:22582081-22582081	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1234C>A; p.P412T; 20:22581990-22581990	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.619A>C; p.I207L; 20:22582605-22582605	urinary_tract; bladder	carcinoma	Substitution - Missense
c.619A>C; p.I207L; 20:22582605-22582605	urinary_tract; bladder	carcinoma	Substitution - Missense
c.488C>T; p.S163L; 20:22582736-22582736	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1068G>A; p.P356P; 20:22582156-22582156	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1323T>A; p.D441E; 20:22581901-22581901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.366C>A; p.G122G; 20:22582858-22582858	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.366C>A; p.G122G; 20:22582858-22582858	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.177C>G; p.S59R; 20:22583047-22583047	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.709C>T; p.P237S; 20:22582515-22582515	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1155G>A; p.E385E; 20:22582069-22582069	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.345G>A; p.G115G; 20:22582879-22582879	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1179C>G; p.H393Q; 20:22582045-22582045	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.69+2T>C; p.?; 20:22584190-22584190	upper_aerodigestive_tract; mouth	carcinoma	Unknown
c.69+2T>C; p.?; 20:22584190-22584190	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Unknown
c.872C>T; p.A291V; 20:22582352-22582352	thyroid	other; neoplasm	Substitution - Missense
c.1284G>A; p.T428T; 20:22581940-22581940	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1284G>A; p.T428T; 20:22581940-22581940	skin	malignant_melanoma	Substitution - coding silent
c.1284G>A; p.T428T; 20:22581940-22581940	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.91A>T; p.M31L; 20:22583133-22583133	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.58G>A; p.A20T; 20:22584203-22584203	pancreas	carcinoma	Substitution - Missense
c.1352G>A; p.R451Q; 20:22581872-22581872	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1352G>A; p.R451Q; 20:22581872-22581872	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.974C>T; p.T325M; 20:22582250-22582250	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.364G>A; p.G122S; 20:22582860-22582860	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.186C>T; p.S62S; 20:22583038-22583038	skin	malignant_melanoma	Substitution - coding silent
c.72C>T; p.G24G; 20:22583152-22583152	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.650T>A; p.F217Y; 20:22582574-22582574	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.350C>T; p.A117V; 20:22582874-22582874	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.517C>A; p.Q173K; 20:22582707-22582707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.517C>A; p.Q173K; 20:22582707-22582707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.31G>T; p.E11*; 20:22584230-22584230	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.620T>C; p.I207T; 20:22582604-22582604	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.545T>A; p.L182Q; 20:22582679-22582679	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1144A>T; p.M382L; 20:22582080-22582080	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>T; p.A78S; 20:22582992-22582992	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.997C>T; p.P333S; 20:22582227-22582227	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.114C>T; p.N38N; 20:22583110-22583110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.261G>T; p.M87I; 20:22582963-22582963	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.517C>T; p.Q173*; 20:22582707-22582707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.517C>T; p.Q173*; 20:22582707-22582707	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.516C>T; p.I172I; 20:22582708-22582708	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.399G>A; p.M133I; 20:22582825-22582825	skin	malignant_melanoma	Substitution - Missense

COSMIC somatic mutation [Top]