Entrez Gene

Basic Information
Gene ID	29945
Name	ANAPC4
Synonymous	anaphase promoting complex subunit 4;ANAPC4;anaphase promoting complex subunit 4
Definition	anaphase-promoting complex subunit 4\|cyclosome subunit 4
Position	4p15.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1823C>A; p.S608Y; 4:25414697-25414697	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2424C>T; p.S808S; 4:25418379-25418379	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.380C>A; p.S127*; 4:25388511-25388511	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1724+8T>G; p.?; 4:25414512-25414512	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.1894A>G; p.R632G; 4:25415533-25415533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1256G>A; p.R419Q; 4:25403012-25403012	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2081A>G; p.D694G; 4:25417621-25417621	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.236-2A>T; p.?; 4:25383259-25383259	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.236-2A>T; p.?; 4:25383259-25383259	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.236-2A>T; p.?; 4:25383259-25383259	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.30C>T; p.S10S; 4:25377457-25377457	skin	malignant_melanoma	Substitution - coding silent
c.30C>T; p.S10S; 4:25377457-25377457	skin	malignant_melanoma	Substitution - coding silent
c.1068G>C; p.S356S; 4:25396670-25396670	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.243C>G; p.A81A; 4:25383268-25383268	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1318A>G; p.M440V; 4:25406829-25406829	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1856A>C; p.K619T; 4:25415495-25415495	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.442A>C; p.N148H; 4:25388573-25388573	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1895G>A; p.R632K; 4:25415534-25415534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1543C>T; p.P515S; 4:25413662-25413662	skin; neck	malignant_melanoma	Substitution - Missense
c.34C>T; p.R12W; 4:25377461-25377461	skin	malignant_melanoma	Substitution - Missense
c.2107C>T; p.R703C; 4:25417647-25417647	liver	carcinoma	Substitution - Missense
c.2107C>T; p.R703C; 4:25417647-25417647	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.573A>G; p.G191G; 4:25390193-25390193	breast	carcinoma	Substitution - coding silent
c.529G>A; p.V177I; 4:25390149-25390149	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.581A>C; p.K194T; 4:25390201-25390201	prostate	carcinoma	Substitution - Missense
c.1431+1G>T; p.?; 4:25407254-25407254	breast	carcinoma	Unknown
c.2088G>A; p.Q696Q; 4:25417628-25417628	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1068G>A; p.S356S; 4:25396670-25396670	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2157A>G; p.A719A; 4:25417697-25417697	bone; pelvis	chondrosarcoma	Substitution - coding silent
c.2013G>T; p.L671F; 4:25416536-25416536	pancreas	NS	Substitution - Missense
c.1414G>A; p.V472I; 4:25407236-25407236	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2015C>A; p.S672Y; 4:25416538-25416538	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2215C>T; p.R739C; 4:25418170-25418170	skin	malignant_melanoma	Substitution - Missense
c.2215C>T; p.R739C; 4:25418170-25418170	skin	malignant_melanoma	Substitution - Missense
c.2182C>T; p.R728*; 4:25417722-25417722	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.846G>C; p.Q282H; 4:25393861-25393861	urinary_tract; bladder	carcinoma	Substitution - Missense
c.616C>T; p.L206F; 4:25390926-25390926	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1685+2T>C; p.?; 4:25414387-25414387	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.2292C>T; p.A764A; 4:25418247-25418247	skin	malignant_melanoma	Substitution - coding silent
c.947A>G; p.E316G; 4:25394676-25394676	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2276A>T; p.D759V; 4:25418231-25418231	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1901+4A>C; p.?; 4:25415544-25415544	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1714T>A; p.F572I; 4:25414494-25414494	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2216G>A; p.R739H; 4:25418171-25418171	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1133C>T; p.P378L; 4:25396735-25396735	skin	malignant_melanoma	Substitution - Missense
c.985-7T>A; p.?; 4:25394822-25394822	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Unknown
c.2331G>T; p.S777S; 4:25418286-25418286	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.496A>C; p.K166Q; 4:25388863-25388863	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.985-7T>A; p.?; 4:25394822-25394822	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Unknown
c.2331G>T; p.S777S; 4:25418286-25418286	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1896A>G; p.R632R; 4:25415535-25415535	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.877G>T; p.E293*; 4:25394310-25394310	breast	carcinoma	Substitution - Nonsense
c.904G>T; p.D302Y; 4:25394337-25394337	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.385T>C; p.Y129H; 4:25388516-25388516	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.223C>T; p.P75S; 4:25380467-25380467	liver	carcinoma	Substitution - Missense
c.2121T>C; p.F707F; 4:25417661-25417661	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2121T>C; p.F707F; 4:25417661-25417661	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2121T>C; p.F707F; 4:25417661-25417661	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2121T>C; p.F707F; 4:25417661-25417661	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.658G>C; p.V220L; 4:25390968-25390968	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.341A>G; p.H114R; 4:25383366-25383366	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2360G>T; p.G787V; 4:25418315-25418315	skin	malignant_melanoma	Substitution - Missense
c.1250T>G; p.F417C; 4:25403006-25403006	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.482C>T; p.S161F; 4:25388849-25388849	skin	malignant_melanoma	Substitution - Missense
c.1159G>A; p.E387K; 4:25396761-25396761	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1184C>A; p.S395Y; 4:25396869-25396869	skin; extremity	malignant_melanoma	Substitution - Missense
c.1781C>T; p.S594L; 4:25414655-25414655	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.748C>T; p.R250W; 4:25392380-25392380	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1841G>T; p.G614V; 4:25415480-25415480	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465*; 4:25407215-25407215	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.481T>C; p.S161P; 4:25388848-25388848	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.556G>T; p.E186*; 4:25390176-25390176	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.749G>A; p.R250Q; 4:25392381-25392381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749G>A; p.R250Q; 4:25392381-25392381	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2377C>A; p.P793T; 4:25418332-25418332	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.29_30CC>AT; p.S10Y; 4:25377456-25377457	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.874C>T; p.Q292*; 4:25393889-25393889	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.90C>T; p.P30P; 4:25377517-25377517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.90C>T; p.P30P; 4:25377517-25377517	skin	malignant_melanoma	Substitution - coding silent
c.658G>A; p.V220I; 4:25390968-25390968	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2200-2A>T; p.?; 4:25418153-25418153	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.404C>G; p.S135*; 4:25388535-25388535	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.404C>G; p.S135*; 4:25388535-25388535	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.404C>G; p.S135*; 4:25388535-25388535	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.404C>G; p.S135*; 4:25388535-25388535	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.182A>G; p.N61S; 4:25380426-25380426	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.441A>C; p.K147N; 4:25388572-25388572	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1158C>T; p.I386I; 4:25396760-25396760	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.1944T>C; p.T648T; 4:25416467-25416467	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2195G>A; p.C732Y; 4:25417735-25417735	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1330G>T; p.D444Y; 4:25406841-25406841	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.463A>C; p.I155L; 4:25388736-25388736	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.659T>C; p.V220A; 4:25390969-25390969	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.659T>C; p.V220A; 4:25390969-25390969	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.659T>C; p.V220A; 4:25390969-25390969	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.659T>C; p.V220A; 4:25390969-25390969	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.321G>A; p.E107E; 4:25383346-25383346	skin	malignant_melanoma	Substitution - coding silent
c.1135C>T; p.L379F; 4:25396737-25396737	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.206C>T; p.T69M; 4:25380450-25380450	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.766A>G; p.T256A; 4:25392398-25392398	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.597A>T; p.T199T; 4:25390217-25390217	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2133G>C; p.W711C; 4:25417673-25417673	breast	carcinoma	Substitution - Missense
c.944C>A; p.A315D; 4:25394673-25394673	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1603C>T; p.Q535*; 4:25413722-25413722	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1375-1G>T; p.?; 4:25407196-25407196	lung	carcinoma; adenocarcinoma	Unknown
c.1524A>G; p.K508K; 4:25409790-25409790	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.462A>G; p.K154K; 4:25388735-25388735	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.133T>G; p.L45V; 4:25380377-25380377	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2262C>T; p.L754L; 4:25418217-25418217	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.81C>T; p.V27V; 4:25377508-25377508	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.463A>G; p.I155V; 4:25388736-25388736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.856C>T; p.R286C; 4:25393871-25393871	skin	malignant_melanoma	Substitution - Missense
c.45A>C; p.G15G; 4:25377472-25377472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.157C>T; p.H53Y; 4:25380401-25380401	skin	malignant_melanoma	Substitution - Missense
c.1005G>T; p.Q335H; 4:25394849-25394849	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.839T>G; p.L280R; 4:25393854-25393854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1005G>T; p.Q335H; 4:25394849-25394849	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.250C>T; p.L84F; 4:25383275-25383275	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1255C>T; p.R419W; 4:25403011-25403011	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.349G>A; p.E117K; 4:25383374-25383374	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1725-1G>A; p.?; 4:25414598-25414598	skin	malignant_melanoma	Unknown
c.658G>T; p.V220F; 4:25390968-25390968	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense

COSMIC somatic mutation [Top]