Entrez Gene

Basic Information
Gene ID	29882
Name	ANAPC2
Synonymous	anaphase promoting complex subunit 2;ANAPC2;anaphase promoting complex subunit 2
Definition	anaphase-promoting complex subunit 2\|cyclosome subunit 2
Position	9q34.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.57G>T; p.E19D; 9:137188476-137188476	pancreas	carcinoma	Substitution - Missense
c.1461C>T; p.A487A; 9:137181688-137181688	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.564G>C; p.K188N; 9:137187657-137187657	breast	carcinoma	Substitution - Missense
c.1277G>A; p.R426H; 9:137183134-137183134	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1788G>T; p.L596L; 9:137180283-137180283	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.981C>T; p.H327H; 9:137184980-137184980	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1215G>A; p.K405K; 9:137183196-137183196	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2210A>C; p.D737A; 9:137175283-137175283	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1805C>T; p.P602L; 9:137180266-137180266	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1558C>T; p.R520C; 9:137180840-137180840	pancreas	carcinoma	Substitution - Missense
c.1558C>T; p.R520C; 9:137180840-137180840	pancreas	carcinoma	Substitution - Missense
c.1956C>T; p.D652D; 9:137175772-137175772	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.845A>G; p.E282G; 9:137186252-137186252	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1928T>C; p.L643P; 9:137175800-137175800	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.845A>G; p.E282G; 9:137186252-137186252	stomach	adenocarcinoma	Substitution - Missense
c.330A>G; p.L110L; 9:137187891-137187891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1543T>A; p.F515I; 9:137180855-137180855	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1705C>T; p.R569C; 9:137180366-137180366	pancreas	carcinoma	Substitution - Missense
c.1992G>A; p.A664A; 9:137175736-137175736	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1248C>A; p.I416I; 9:137183163-137183163	ovary	other; neoplasm	Substitution - coding silent
c.1599C>T; p.F533F; 9:137180799-137180799	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1852G>T; p.A618S; 9:137180219-137180219	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.808C>T; p.R270W; 9:137186289-137186289	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1238C>T; p.S413F; 9:137183173-137183173	skin	malignant_melanoma	Substitution - Missense
c.1875G>T; p.K625N; 9:137180196-137180196	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1042G>A; p.V348I; 9:137184919-137184919	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2427C>A; p.V809V; 9:137174984-137174984	ovary	other; neoplasm	Substitution - coding silent
c.2427C>A; p.V809V; 9:137174984-137174984	ovary	other; neoplasm	Substitution - coding silent
c.578G>A; p.G193E; 9:137187643-137187643	skin	malignant_melanoma	Substitution - Missense
c.1873A>G; p.K625E; 9:137180198-137180198	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1873A>G; p.K625E; 9:137180198-137180198	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.244G>A; p.D82N; 9:137187977-137187977	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1884G>C; p.Q628H; 9:137180187-137180187	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1747G>T; p.A583S; 9:137180324-137180324	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.822G>A; p.E274E; 9:137186275-137186275	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.837C>T; p.G279G; 9:137186260-137186260	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1941C>T; p.D647D; 9:137175787-137175787	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2169_2170CC>TT; p.R724W; 9:137175323-137175324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.908T>G; p.V303G; 9:137185053-137185053	liver	carcinoma	Substitution - Missense
c.1603_1604CC>TT; p.P535F; 9:137180794-137180795	skin	malignant_melanoma	Substitution - Missense
c.1768_1769GG>AA; p.G590K; 9:137180302-137180303	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.967C>T; p.R323C; 9:137184994-137184994	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1897C>T; p.R633W; 9:137175831-137175831	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1602C>T; p.S534S; 9:137180796-137180796	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1724G>A; p.R575Q; 9:137180347-137180347	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1380C>A; p.D460E; 9:137181769-137181769	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1692G>C; p.M564I; 9:137180379-137180379	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1195C>A; p.L399I; 9:137183216-137183216	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.20T>C; p.V7A; 9:137188513-137188513	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.732C>T; p.S244S; 9:137187489-137187489	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2205G>C; p.E735D; 9:137175288-137175288	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1892C>T; p.A631V; 9:137175836-137175836	skin; extremity	malignant_melanoma	Substitution - Missense
c.780T>C; p.A260A; 9:137186317-137186317	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1349G>A; p.G450E; 9:137181800-137181800	skin	malignant_melanoma	Substitution - Missense
c.964C>T; p.R322C; 9:137184997-137184997	central_nervous_system; spinal_cord	glioma; ependymoma	Substitution - Missense
c.2039A>T; p.E680V; 9:137175454-137175454	liver	carcinoma	Substitution - Missense
c.2039A>T; p.E680V; 9:137175454-137175454	liver	carcinoma	Substitution - Missense
c.669G>A; p.G223G; 9:137187552-137187552	breast	carcinoma	Substitution - coding silent
c.2217C>T; p.G739G; 9:137175276-137175276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.868C>A; p.H290N; 9:137186229-137186229	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1045C>T; p.R349*; 9:137184916-137184916	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2220G>C; p.M740I; 9:137175273-137175273	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2130delC; p.G711fs*52; 9:137175363-137175363	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1183G>C; p.D395H; 9:137183228-137183228	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1899G>A; p.R633R; 9:137175829-137175829	breast	carcinoma	Substitution - coding silent
c.1487G>A; p.R496Q; 9:137180911-137180911	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1021A>G; p.I341V; 9:137184940-137184940	central_nervous_system; brain	glioma	Substitution - Missense
c.2068G>T; p.A690S; 9:137175425-137175425	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1041C>T; p.I347I; 9:137184920-137184920	skin	malignant_melanoma	Substitution - coding silent
c.2387A>T; p.Q796L; 9:137175024-137175024	liver	carcinoma	Substitution - Missense
c.2387A>T; p.Q796L; 9:137175024-137175024	liver	carcinoma	Substitution - Missense
c.1404G>A; p.Q468Q; 9:137181745-137181745	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2080C>T; p.R694W; 9:137175413-137175413	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.409C>T; p.R137C; 9:137187812-137187812	skin	malignant_melanoma	Substitution - Missense
c.1008C>T; p.Y336Y; 9:137184953-137184953	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2046C>G; p.S682R; 9:137175447-137175447	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.1763C>T; p.P588L; 9:137180308-137180308	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1324C>T; p.L442L; 9:137181825-137181825	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1265A>G; p.E422G; 9:137183146-137183146	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1559G>A; p.R520H; 9:137180839-137180839	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1333_1334insG; p.D445fs*11; 9:137181815-137181816	skin	malignant_melanoma	Insertion - Frameshift
c.1445C>T; p.P482L; 9:137181704-137181704	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1493C>T; p.S498L; 9:137180905-137180905	skin	malignant_melanoma	Substitution - Missense
c.1367T>C; p.L456P; 9:137181782-137181782	skin	malignant_melanoma	Substitution - Missense
c.920A>G; p.D307G; 9:137185041-137185041	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.920A>G; p.D307G; 9:137185041-137185041	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1222C>A; p.R408S; 9:137183189-137183189	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.22G>T; p.A8S; 9:137188511-137188511	skin	malignant_melanoma	Substitution - Missense
c.2229G>T; p.Q743H; 9:137175264-137175264	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1126G>A; p.V376M; 9:137183714-137183714	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.982G>A; p.V328M; 9:137184979-137184979	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.982G>A; p.V328M; 9:137184979-137184979	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2344G>A; p.V782M; 9:137175067-137175067	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.982G>A; p.V328M; 9:137184979-137184979	ovary	carcinoma	Substitution - Missense
c.1385C>T; p.A462V; 9:137181764-137181764	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.607C>A; p.L203M; 9:137187614-137187614	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.809G>A; p.R270Q; 9:137186288-137186288	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1839G>T; p.E613D; 9:137180232-137180232	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.415G>A; p.G139S; 9:137187806-137187806	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.936C>T; p.P312P; 9:137185025-137185025	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1864T>C; p.Y622H; 9:137180207-137180207	skin	malignant_melanoma	Substitution - Missense
c.1490G>A; p.R497H; 9:137180908-137180908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.410G>A; p.R137H; 9:137187811-137187811	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.185T>C; p.L62P; 9:137188036-137188036	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2306C>T; p.S769L; 9:137175105-137175105	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1695G>A; p.A565A; 9:137180376-137180376	pancreas	carcinoma	Substitution - coding silent
c.1342G>A; p.G448R; 9:137181807-137181807	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1486_1487CG>TT; p.R496L; 9:137180911-137180912	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>T; p.R158R; 9:137187747-137187747	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.617G>T; p.R206L; 9:137187604-137187604	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.394C>A; p.L132M; 9:137187827-137187827	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1225G>A; p.V409M; 9:137183186-137183186	liver	carcinoma	Substitution - Missense
c.1225G>A; p.V409M; 9:137183186-137183186	liver	carcinoma	Substitution - Missense
c.1225G>A; p.V409M; 9:137183186-137183186	liver	carcinoma	Substitution - Missense
c.1019G>A; p.R340H; 9:137184942-137184942	skin	malignant_melanoma	Substitution - Missense
c.1019G>A; p.R340H; 9:137184942-137184942	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2170C>T; p.R724W; 9:137175323-137175323	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1405G>A; p.D469N; 9:137181744-137181744	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1485G>T; p.K495N; 9:137180913-137180913	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>T; p.E52*; 9:137188067-137188067	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.1887C>T; p.L629L; 9:137180184-137180184	skin	malignant_melanoma	Substitution - coding silent
c.863A>C; p.E288A; 9:137186234-137186234	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1382C>T; p.P461L; 9:137181767-137181767	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2002C>T; p.L668L; 9:137175726-137175726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1224C>T; p.R408R; 9:137183187-137183187	thyroid	other; neoplasm	Substitution - coding silent
c.1224C>T; p.R408R; 9:137183187-137183187	thyroid	other; neoplasm	Substitution - coding silent

COSMIC somatic mutation [Top]