Entrez Gene

Basic Information
Gene ID	2821
Name	GPI
Synonymous	glucose-6-phosphate isomerase;GPI;glucose-6-phosphate isomerase
Definition	autocrine motility factor\|glucose phosphate isomerase\|hexose monophosphate isomerase\|hexosephosphate isomerase\|neuroleukin\|oxoisomerase\|phosphoglucose isomerase\|phosphohexomutase\|phosphohexose isomerase\|phosphosaccharomutase\|sperm antigen 36\|sperm antigen
Position	19q13.1
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1108C>T; p.R370C; 19:34396346-34396346	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1227G>A; p.P409P; 19:34396615-34396615	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.316C>T; p.R106W; 19:34368616-34368616	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.171G>C; p.K57N; 19:34366393-34366393	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.376C>T; p.L126L; 19:34368676-34368676	skin	malignant_melanoma	Substitution - coding silent
c.740C>G; p.S247C; 19:34379552-34379552	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.16_17insG; p.D7fs*82; 19:34365282-34365283	breast	carcinoma	Insertion - Frameshift
c.893C>T; p.S298L; 19:34393755-34393755	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1337G>A; p.R446Q; 19:34399274-34399274	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1245C>T; p.P415P; 19:34396633-34396633	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1478T>C; p.M493T; 19:34399722-34399722	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.827T>C; p.L276P; 19:34393270-34393270	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1462G>A; p.G488R; 19:34399619-34399619	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1275C>T; p.L425L; 19:34399212-34399212	skin	malignant_melanoma	Substitution - coding silent
c.357G>T; p.M119I; 19:34368657-34368657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1610C>G; p.S537C; 19:34399969-34399969	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1250G>A; p.R417Q; 19:34396638-34396638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1250G>A; p.R417Q; 19:34396638-34396638	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.761A>T; p.K254M; 19:34381476-34381476	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.213G>C; p.L71F; 19:34366435-34366435	skin; trunk	malignant_melanoma	Substitution - Missense
c.147G>A; p.G49G; 19:34366369-34366369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1052A>T; p.Y351F; 19:34394056-34394056	pancreas	carcinoma	Substitution - Missense
c.257A>G; p.N86S; 19:34366826-34366826	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1040G>A; p.R347H; 19:34394044-34394044	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.392C>A; p.S131Y; 19:34368692-34368692	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.479C>T; p.S160F; 19:34377579-34377579	skin	malignant_melanoma	Substitution - Missense
c.127A>G; p.T43A; 19:34366349-34366349	skin	malignant_melanoma	Substitution - Missense
c.1287C>G; p.F429L; 19:34399224-34399224	breast	carcinoma	Substitution - Missense
c.489A>G; p.G163G; 19:34377737-34377737	thyroid	other; neoplasm	Substitution - coding silent
c.489A>G; p.G163G; 19:34377737-34377737	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.464T>G; p.I155S; 19:34377564-34377564	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.792C>T; p.F264F; 19:34381507-34381507	breast	carcinoma	Substitution - coding silent
c.1087T>C; p.Y363H; 19:34396325-34396325	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.817C>T; p.R273C; 19:34393260-34393260	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1474G>A; p.A492T; 19:34399631-34399631	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.631A>G; p.K211E; 19:34377879-34377879	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.539G>A; p.R180H; 19:34377787-34377787	urinary_tract; bladder	carcinoma	Substitution - Missense
c.695C>A; p.A232E; 19:34378995-34378995	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.320C>G; p.S107*; 19:34368620-34368620	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.303G>A; p.V101V; 19:34368603-34368603	pancreas	carcinoid-endocrine_tumour	Substitution - coding silent
c.448A>G; p.T150A; 19:34377548-34377548	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>A; p.V318I; 19:34393956-34393956	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.705+1G>A; p.?; 19:34379006-34379006	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1182C>T; p.L394L; 19:34396420-34396420	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1656G>A; p.Q552Q; 19:34400015-34400015	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1656G>A; p.Q552Q; 19:34400015-34400015	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.418G>T; p.D140Y; 19:34377518-34377518	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1213G>A; p.D405N; 19:34396601-34396601	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1208C>T; p.P403L; 19:34396596-34396596	skin; mucosal	malignant_melanoma	Substitution - Missense
c.480C>T; p.S160S; 19:34377580-34377580	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1600C>T; p.Q534*; 19:34399959-34399959	prostate	adenoma	Substitution - Nonsense
c.420C>T; p.D140D; 19:34377520-34377520	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.247C>T; p.R83W; 19:34366816-34366816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1497C>T; p.F499F; 19:34399741-34399741	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1056C>T; p.F352F; 19:34394060-34394060	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.597G>T; p.L199L; 19:34377845-34377845	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.90C>T; p.F30F; 19:34365356-34365356	skin	malignant_melanoma	Substitution - coding silent
c.843A>C; p.G281G; 19:34393286-34393286	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.918C>G; p.H306Q; 19:34393922-34393922	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1566T>C; p.A522A; 19:34399925-34399925	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1566T>C; p.A522A; 19:34399925-34399925	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.4G>A; p.A2T; 19:34365270-34365270	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1186C>T; p.H396Y; 19:34396424-34396424	skin	malignant_melanoma	Substitution - Missense
c.378G>A; p.L126L; 19:34368678-34368678	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.409C>T; p.R137W; 19:34377509-34377509	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.437G>A; p.G146D; 19:34377537-34377537	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1491G>T; p.K497N; 19:34399735-34399735	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.441G>T; p.K147N; 19:34377541-34377541	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1050G>A; p.A350A; 19:34394054-34394054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.452A>T; p.D151V; 19:34377552-34377552	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.156G>T; p.L52L; 19:34366378-34366378	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1099T>C; p.S367P; 19:34396337-34396337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.396C>T; p.F132F; 19:34368696-34368696	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1100C>G; p.S367C; 19:34396338-34396338	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1287C>T; p.F429F; 19:34399224-34399224	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.333C>T; p.I111I; 19:34368633-34368633	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1022A>G; p.Y341C; 19:34394026-34394026	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.228C>T; p.G76G; 19:34366797-34366797	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1104A>G; p.G368G; 19:34396342-34396342	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.242G>A; p.R81Q; 19:34366811-34366811	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.402+1G>A; p.?; 19:34368703-34368703	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1514G>A; p.W505*; 19:34399758-34399758	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1139delG; p.E382fs*20; 19:34396377-34396377	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.263A>T; p.E88V; 19:34366832-34366832	prostate	carcinoma	Substitution - Missense
c.1127G>A; p.G376D; 19:34396365-34396365	ovary	other; neoplasm	Substitution - Missense
c.830G>A; p.W277*; 19:34393273-34393273	liver	carcinoma	Substitution - Nonsense
c.830G>A; p.W277*; 19:34393273-34393273	liver	carcinoma	Substitution - Nonsense
c.357G>A; p.M119I; 19:34368657-34368657	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1143G>A; p.G381G; 19:34396381-34396381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.625G>A; p.A209T; 19:34377873-34377873	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.496A>T; p.M166L; 19:34377744-34377744	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.861C>T; p.H287H; 19:34393304-34393304	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1066G>A; p.D356N; 19:34396304-34396304	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1597G>T; p.A533S; 19:34399956-34399956	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1287C>A; p.F429L; 19:34399224-34399224	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1597G>T; p.A533S; 19:34399956-34399956	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1050G>T; p.A350A; 19:34394054-34394054	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1291G>A; p.A431T; 19:34399228-34399228	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1074G>A; p.E358E; 19:34396312-34396312	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1063-1G>T; p.?; 19:34396300-34396300	ovary	other; neoplasm	Unknown
c.836C>A; p.A279D; 19:34393279-34393279	large_intestine; colon	carcinoma	Substitution - Missense
c.836C>A; p.A279D; 19:34393279-34393279	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1323G>A; p.S441S; 19:34399260-34399260	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1455C>T; p.F485F; 19:34399612-34399612	soft_tissue; blood_vessel	angiosarcoma	Substitution - coding silent
c.1322C>T; p.S441L; 19:34399259-34399259	skin; trunk	malignant_melanoma	Substitution - Missense
c.45A>G; p.Q15Q; 19:34365311-34365311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.45A>G; p.Q15Q; 19:34365311-34365311	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.748A>G; p.T250A; 19:34379560-34379560	breast	carcinoma	Substitution - Missense
c.403C>T; p.R135C; 19:34377503-34377503	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1356G>A; p.A452A; 19:34399293-34399293	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]