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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

2775

Name

GNAO1

Synonymous

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O;GNAO1;guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

Definition

guanine nucleotide-binding protein G(o) subunit alpha

Position

16q13

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1062C>G; p.Y354*; 16:56355050-56355050

 central_nervous_system; braingliomaSubstitution - Nonsense

c.758C>A; p.S253Y; 16:56351418-56351418

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.825T>A; p.F275L; 16:56351485-56351485

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.724A>C; p.N242H; 16:56351384-56351384

 skinmalignant_melanomaSubstitution - Missense

c.275G>A; p.G92D; 16:56276044-56276044

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.280G>A; p.E94K; 16:56276049-56276049

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.118G>A; p.G40R; 16:56192353-56192353

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.425A>G; p.N142S; 16:56328752-56328752

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.425A>G; p.N142S; 16:56328752-56328752

 ovaryother; neoplasmSubstitution - Missense

c.651G>A; p.E217E; 16:56336788-56336788

 skinmalignant_melanomaSubstitution - coding silent

c.382A>G; p.M128V; 16:56328709-56328709

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.714C>T; p.D238D; 16:56336851-56336851

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.728G>A; p.R243H; 16:56351388-56351388

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.134G>A; p.G45E; 16:56192589-56192589

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.607G>A; p.G203R; 16:56336744-56336744

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.411C>T; p.I137I; 16:56328738-56328738

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.941C>T; p.S314L; 16:56354929-56354929

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.941C>T; p.S314L; 16:56354929-56354929

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.978C>T; p.A326A; 16:56354966-56354966

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.310G>T; p.A104S; 16:56328637-56328637

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.119G>C; p.G40A; 16:56192574-56192574

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.399C>T; p.G133G; 16:56328726-56328726

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.969G>A; p.M323I; 16:56354957-56354957

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.156G>A; p.Q52Q; 16:56192611-56192611

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.325G>A; p.D109N; 16:56328652-56328652

 oesophaguscarcinomaSubstitution - Missense

c.1044C>G; p.L348L; 16:56355032-56355032

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.195C>T; p.D65D; 16:56275964-56275964

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1053C>T; p.C351C; 16:56355041-56355041

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1045C>T; p.R349W; 16:56355033-56355033

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.727C>T; p.R243C; 16:56351387-56351387

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.481G>A; p.D161N; 16:56334745-56334745

 breastcarcinomaSubstitution - Missense

c.1009G>C; p.D337H; 16:56354997-56354997

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.330delG; p.V111fs*1; 16:56328657-56328657

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.648C>A; p.F216L; 16:56336785-56336785

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.625C>T; p.R209C; 16:56336762-56336762

 pancreascarcinomaSubstitution - Missense

c.625C>T; p.R209C; 16:56336762-56336762

 large_intestine; colonadenomaSubstitution - Missense

c.777C>A; p.F259L; 16:56351437-56351437

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.966C>A; p.H322Q; 16:56354954-56354954

 skinmalignant_melanomaSubstitution - Missense

c.209A>C; p.K70T; 16:56275978-56275978

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.753C>T; p.F251F; 16:56351413-56351413

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.753C>T; p.F251F; 16:56351413-56351413

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.606C>T; p.V202V; 16:56336743-56336743

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.444G>A; p.Q148Q; 16:56328771-56328771

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.801C>G; p.L267L; 16:56351461-56351461

 livercarcinomaSubstitution - coding silent

c.606C>T; p.V202V; 16:56336743-56336743

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.187G>A; p.G63R; 16:56275956-56275956

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.346_347GA>AG; p.D116S; 16:56328673-56328674

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.35C>T; p.A12V; 16:56192270-56192270

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1009G>A; p.D337N; 16:56354997-56354997

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.434G>T; p.R145L; 16:56328761-56328761

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.111C>A; p.L37L; 16:56192346-56192346

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.1009G>A; p.D337N; 16:56354997-56354997

 breastcarcinomaSubstitution - Missense

c.256C>T; p.R86W; 16:56276025-56276025

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.380C>A; p.A127D; 16:56328707-56328707

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.434G>A; p.R145Q; 16:56328761-56328761

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.394T>C; p.W132R; 16:56328721-56328721

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.897C>T; p.D299D; 16:56354885-56354885

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.897C>T; p.D299D; 16:56354885-56354885

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.897C>T; p.D299D; 16:56354885-56354885

 breastcarcinomaSubstitution - coding silent

c.754G>A; p.D252N; 16:56351414-56351414

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.679G>A; p.A227T; 16:56336816-56336816

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.679G>A; p.A227T; 16:56336816-56336816

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.757T>G; p.S253A; 16:56351417-56351417

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.649G>A; p.E217K; 16:56336786-56336786

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.649G>A; p.E217K; 16:56336786-56336786

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.555C>G; p.I185M; 16:56334819-56334819

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.191A>C; p.E64A; 16:56275960-56275960

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.252C>T; p.I84I; 16:56276021-56276021

 thyroidcarcinomaSubstitution - coding silent

c.252C>T; p.I84I; 16:56276021-56276021

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.123T>A; p.A41A; 16:56192578-56192578

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.338G>A; p.R113Q; 16:56328665-56328665

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.84C>G; p.I28M; 16:56192319-56192319

 central_nervous_system; braingliomaSubstitution - Missense

c.342G>T; p.M114I; 16:56328669-56328669

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.822C>G; p.L274L; 16:56351482-56351482

 urinary_tract; bladdercarcinomaSubstitution - coding silent

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