Entrez Gene

Basic Information
Gene ID	23515
Name	MORC3
Synonymous	MORC family CW-type zinc finger 3;MORC3;MORC family CW-type zinc finger 3
Definition	MORC family CW-type zinc finger protein 3\|nuclear matrix protein NXP2\|zinc finger CW-type coiled-coil domain protein 3\|zinc finger, CW type with coiled-coil domain 3\|zinc finger, CW-type with coiled-coil domain 3
Position	21q22.13
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.539A>C; p.K180T; 21:36338852-36338852	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.573G>T; p.K191N; 21:36338886-36338886	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1564A>T; p.T522S; 21:36364204-36364204	pancreas	carcinoma	Substitution - Missense
c.537G>A; p.Q179Q; 21:36338850-36338850	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.537G>A; p.Q179Q; 21:36338850-36338850	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.2197G>T; p.E733*; 21:36369565-36369565	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2301_2302CC>TT; p.H768Y; 21:36369669-36369670	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1843G>A; p.D615N; 21:36369211-36369211	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1643G>T; p.R548L; 21:36369011-36369011	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1270G>C; p.D424H; 21:36360016-36360016	breast	carcinoma	Substitution - Missense
c.1517A>G; p.E506G; 21:36364157-36364157	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1597C>G; p.Q533E; 21:36364237-36364237	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.605G>A; p.R202K; 21:36338918-36338918	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1568G>A; p.R523K; 21:36364208-36364208	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.48G>A; p.P16P; 21:36333654-36333654	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.48G>A; p.P16P; 21:36333654-36333654	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1726G>A; p.D576N; 21:36369094-36369094	skin	malignant_melanoma	Substitution - Missense
c.1969G>A; p.D657N; 21:36369337-36369337	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.585G>T; p.R195S; 21:36338898-36338898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1117G>A; p.A373T; 21:36356633-36356633	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2034A>G; p.I678M; 21:36369402-36369402	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1920C>A; p.T640T; 21:36369288-36369288	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1126G>A; p.E376K; 21:36356642-36356642	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1006G>T; p.A336S; 21:36349311-36349311	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1029G>T; p.V343V; 21:36349334-36349334	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2063C>T; p.S688F; 21:36369431-36369431	urinary_tract; bladder	carcinoma	Substitution - Missense
c.48G>T; p.P16P; 21:36333654-36333654	liver	carcinoma	Substitution - coding silent
c.48G>T; p.P16P; 21:36333654-36333654	liver	carcinoma	Substitution - coding silent
c.877A>G; p.K293E; 21:36344699-36344699	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.641A>T; p.K214M; 21:36341431-36341431	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2694C>T; p.N898N; 21:36375170-36375170	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.317C>T; p.S106L; 21:36337803-36337803	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2603C>T; p.T868M; 21:36372468-36372468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2603C>T; p.T868M; 21:36372468-36372468	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.969C>T; p.L323L; 21:36344995-36344995	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1599G>T; p.Q533H; 21:36364239-36364239	prostate	carcinoma	Substitution - Missense
c.2621C>A; p.T874K; 21:36372486-36372486	urinary_tract; bladder	carcinoma	Substitution - Missense
c.394C>G; p.Q132E; 21:36337880-36337880	urinary_tract; bladder	carcinoma	Substitution - Missense
c.550G>A; p.E184K; 21:36338863-36338863	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.872G>A; p.R291Q; 21:36344694-36344694	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.806G>A; p.R269H; 21:36344628-36344628	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.717G>A; p.R239R; 21:36341507-36341507	breast	carcinoma	Substitution - coding silent
c.1346C>G; p.P449R; 21:36360198-36360198	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.23G>A; p.G8E; 21:36320287-36320287	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1508_1510delCTC; p.P504delP; 21:36364148-36364150	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1705A>G; p.K569E; 21:36369073-36369073	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2543G>A; p.R848H; 21:36372408-36372408	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.1658A>G; p.N553S; 21:36369026-36369026	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1597C>A; p.Q533K; 21:36364237-36364237	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1224G>C; p.Q408H; 21:36359970-36359970	breast	carcinoma	Substitution - Missense
c.667G>T; p.E223*; 21:36341457-36341457	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.66T>A; p.N22K; 21:36333672-36333672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1771G>T; p.D591Y; 21:36369139-36369139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2794C>A; p.Q932K; 21:36375270-36375270	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.933T>C; p.D311D; 21:36344959-36344959	skin	malignant_melanoma	Substitution - coding silent
c.2076A>G; p.A692A; 21:36369444-36369444	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1874C>T; p.T625I; 21:36369242-36369242	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1886C>T; p.S629L; 21:36369254-36369254	breast	carcinoma	Substitution - Missense
c.1965T>A; p.V655V; 21:36369333-36369333	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1192C>T; p.P398S; 21:36356708-36356708	pituitary; craniopharyngeal_duct	craniopharyngioma; papillary	Substitution - Missense
c.1795G>T; p.E599*; 21:36369163-36369163	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1828G>A; p.V610I; 21:36369196-36369196	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2113C>T; p.L705F; 21:36369481-36369481	skin	malignant_melanoma	Substitution - Missense
c.1605A>C; p.E535D; 21:36364245-36364245	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.438A>T; p.P146P; 21:36337924-36337924	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.329G>A; p.R110H; 21:36337815-36337815	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.329G>A; p.R110H; 21:36337815-36337815	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.98T>C; p.V33A; 21:36333704-36333704	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.349G>A; p.V117I; 21:36337835-36337835	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2525T>A; p.M842K; 21:36372390-36372390	oesophagus	carcinoma	Substitution - Missense
c.625G>T; p.E209*; 21:36341415-36341415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2798T>C; p.M933T; 21:36375274-36375274	skin	malignant_melanoma	Substitution - Missense
c.1645_1646insC; p.S550fs*12; 21:36369013-36369014	peritoneum; appendix	other; pseudomyxoma_peritonei	Insertion - Frameshift
c.2542C>T; p.R848C; 21:36372407-36372407	skin	malignant_melanoma	Substitution - Missense
c.2542C>T; p.R848C; 21:36372407-36372407	skin	malignant_melanoma	Substitution - Missense
c.562A>G; p.I188V; 21:36338875-36338875	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.674T>C; p.L225S; 21:36341464-36341464	liver	carcinoma	Substitution - Missense
c.940G>A; p.G314R; 21:36344966-36344966	urinary_tract; bladder	carcinoma	Substitution - Missense
c.940G>A; p.G314R; 21:36344966-36344966	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2535A>G; p.S845S; 21:36372400-36372400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2687G>C; p.R896P; 21:36375163-36375163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1450C>T; p.R484W; 21:36362226-36362226	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.206G>A; p.G69E; 21:36336967-36336967	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; NK-T_cell_lymphoma	Substitution - Missense
c.667G>A; p.E223K; 21:36341457-36341457	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1609G>T; p.E537*; 21:36364249-36364249	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Nonsense
c.40-2A>C; p.?; 21:36333644-36333644	oesophagus	carcinoma; adenocarcinoma	Unknown
c.554T>C; p.L185P; 21:36338867-36338867	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2190G>T; p.R730S; 21:36369558-36369558	ovary	other; neoplasm	Substitution - Missense
c.2083C>T; p.Q695*; 21:36369451-36369451	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2108T>C; p.L703P; 21:36369476-36369476	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.609-1G>A; p.?; 21:36341398-36341398	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.953A>G; p.Y318C; 21:36344979-36344979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1684C>G; p.Q562E; 21:36369052-36369052	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2199A>G; p.E733E; 21:36369567-36369567	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1213C>T; p.R405C; 21:36359959-36359959	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1259G>A; p.R420Q; 21:36360005-36360005	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1259G>A; p.R420Q; 21:36360005-36360005	prostate	carcinoma	Substitution - Missense
c.516T>C; p.H172H; 21:36338829-36338829	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.611A>G; p.Y204C; 21:36341401-36341401	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1927G>A; p.E643K; 21:36369295-36369295	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.581C>T; p.T194M; 21:36338894-36338894	skin	malignant_melanoma	Substitution - Missense
c.581C>T; p.T194M; 21:36338894-36338894	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1788G>T; p.M596I; 21:36369156-36369156	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1214G>A; p.R405H; 21:36359960-36359960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2711C>T; p.A904V; 21:36375187-36375187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2614G>A; p.V872I; 21:36372479-36372479	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1744G>T; p.E582*; 21:36369112-36369112	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2091A>G; p.Q697Q; 21:36369459-36369459	liver	carcinoma	Substitution - coding silent
c.2091A>G; p.Q697Q; 21:36369459-36369459	liver	carcinoma	Substitution - coding silent
c.112G>A; p.D38N; 21:36333718-36333718	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1511C>A; p.P504H; 21:36364151-36364151	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1475G>A; p.R492Q; 21:36364115-36364115	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.349_350insT; p.T119fs*40; 21:36337835-36337836	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1665G>T; p.K555N; 21:36369033-36369033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.665C>T; p.P222L; 21:36341455-36341455	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.996T>C; p.C332C; 21:36345022-36345022	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1740A>G; p.L580L; 21:36369108-36369108	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.628T>C; p.F210L; 21:36341418-36341418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1623G>C; p.L541F; 21:36368991-36368991	breast	carcinoma	Substitution - Missense
c.2615T>C; p.V872A; 21:36372480-36372480	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.450C>T; p.F150F; 21:36337936-36337936	skin	malignant_melanoma	Substitution - coding silent
c.2695G>A; p.V899I; 21:36375171-36375171	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.450C>G; p.F150L; 21:36337936-36337936	central_nervous_system; brain	glioma; astrocytoma_Grade_III	Substitution - Missense
c.69T>A; p.S23S; 21:36333675-36333675	kidney	other; neoplasm	Substitution - coding silent
c.1577A>G; p.N526S; 21:36364217-36364217	liver	carcinoma	Substitution - Missense
c.1577A>G; p.N526S; 21:36364217-36364217	liver	carcinoma	Substitution - Missense
c.2178G>T; p.V726V; 21:36369546-36369546	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.705G>A; p.K235K; 21:36341495-36341495	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1725A>T; p.E575D; 21:36369093-36369093	NS	malignant_melanoma	Substitution - Missense
c.1541C>T; p.S514L; 21:36364181-36364181	skin	malignant_melanoma	Substitution - Missense
c.1318G>T; p.D440Y; 21:36360064-36360064	liver	carcinoma	Substitution - Missense
c.941G>A; p.G314E; 21:36344967-36344967	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1318G>T; p.D440Y; 21:36360064-36360064	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.104A>G; p.E35G; 21:36333710-36333710	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1718A>G; p.D573G; 21:36369086-36369086	urinary_tract; bladder	carcinoma	Substitution - Missense
c.530C>T; p.T177M; 21:36338843-36338843	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1399delA; p.K468fs*14; 21:36360251-36360251	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.2142A>C; p.K714N; 21:36369510-36369510	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1091C>A; p.T364N; 21:36349396-36349396	urinary_tract; bladder	carcinoma	Substitution - Missense
c.420G>A; p.A140A; 21:36337906-36337906	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.420G>A; p.A140A; 21:36337906-36337906	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.855C>A; p.I285I; 21:36344677-36344677	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.179A>G; p.H60R; 21:36336940-36336940	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.179A>G; p.H60R; 21:36336940-36336940	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2452G>A; p.D818N; 21:36369820-36369820	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2452G>A; p.D818N; 21:36369820-36369820	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1092T>C; p.T364T; 21:36349397-36349397	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1436C>T; p.P479L; 21:36362212-36362212	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.568G>T; p.G190C; 21:36338881-36338881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2506G>A; p.E836K; 21:36369874-36369874	breast	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]