Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

22943

Name

DKK1

Synonymous

dickkopf WNT signaling pathway inhibitor 1;DKK1;dickkopf WNT signaling pathway inhibitor 1

Definition

dickkopf 1 homolog|dickkopf related protein-1|dickkopf-1 like|dickkopf-like protein 1|dickkopf-related protein 1|hDkk-1

Position

10q11.2

Gene Type

protein-coding

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.182G>T; p.S61I; 10:52314616-52314616

 livercarcinomaSubstitution - Missense

c.167C>A; p.P56Q; 10:52314601-52314601

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.183C>T; p.S61S; 10:52314617-52314617

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.390G>A; p.G130G; 10:52315069-52315069

 skinmalignant_melanomaSubstitution - coding silent

c.140C>A; p.P47Q; 10:52314574-52314574

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.187G>T; p.A63S; 10:52314621-52314621

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.358C>T; p.R120C; 10:52315037-52315037

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.113A>C; p.N38T; 10:52314547-52314547

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.579A>G; p.S193S; 10:52316585-52316585

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.99G>A; p.L33L; 10:52314533-52314533

 breastcarcinomaSubstitution - coding silent

c.551A>G; p.Q184R; 10:52316557-52316557

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.352C>T; p.R118*; 10:52315031-52315031

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.352C>T; p.R118*; 10:52315031-52315031

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.245C>A; p.P82Q; 10:52314924-52314924

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.633A>G; p.K211K; 10:52316639-52316639

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.433C>T; p.H145Y; 10:52316321-52316321

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.176C>A; p.A59E; 10:52314610-52314610

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.64G>A; p.G22S; 10:52314498-52314498

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.332G>T; p.C111F; 10:52315011-52315011

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.539A>C; p.H180P; 10:52316427-52316427

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.770C>T; p.S257F; 10:52316776-52316776

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.661A>G; p.T221A; 10:52316667-52316667

 skinmalignant_melanomaSubstitution - Missense

c.463A>G; p.T155A; 10:52316351-52316351

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.120C>A; p.N40K; 10:52314554-52314554

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.566G>C; p.C189S; 10:52316572-52316572

 large_intestine; rectumNSSubstitution - Missense

c.320G>A; p.G107D; 10:52314999-52314999

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.91G>A; p.A31T; 10:52314525-52314525

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.748G>A; p.D250N; 10:52316754-52316754

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.748G>A; p.D250N; 10:52316754-52316754

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.674G>A; p.R225K; 10:52316680-52316680

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.501G>A; p.G167G; 10:52316389-52316389

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.386C>T; p.P129L; 10:52315065-52315065

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.694G>T; p.E232*; 10:52316700-52316700

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.621C>T; p.S207S; 10:52316627-52316627

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.694G>T; p.E232*; 10:52316700-52316700

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.93C>A; p.A31A; 10:52314527-52314527

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.300C>A; p.P100P; 10:52314979-52314979

 autonomic_ganglianeuroblastomaSubstitution - coding silent

c.211G>A; p.G71R; 10:52314645-52314645

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.121G>A; p.A41T; 10:52314555-52314555

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.121G>A; p.A41T; 10:52314555-52314555

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.711T>A; p.C237*; 10:52316717-52316717

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.373G>A; p.A125T; 10:52315052-52315052

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.152G>A; p.G51D; 10:52314586-52314586

 skinmalignant_melanomaSubstitution - Missense

c.15C>T; p.G5G; 10:52314449-52314449

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.158C>T; p.A53V; 10:52314592-52314592

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.672G>C; p.R224S; 10:52316678-52316678

 upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.205C>T; p.P69S; 10:52314639-52314639

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.572G>T; p.R191L; 10:52316578-52316578

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.292G>A; p.A98T; 10:52314971-52314971

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.620C>A; p.S207Y; 10:52316626-52316626

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.230T>C; p.I77T; 10:52314664-52314664

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.85G>T; p.V29L; 10:52314519-52314519

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.527C>A; p.S176*; 10:52316415-52316415

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.707G>A; p.R236H; 10:52316713-52316713

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.391A>C; p.N131H; 10:52315070-52315070

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.668A>G; p.H223R; 10:52316674-52316674

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.668A>G; p.H223R; 10:52316674-52316674

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.552A>C; p.Q184H; 10:52316558-52316558

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.759A>T; p.Q253H; 10:52316765-52316765

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.139C>A; p.P47T; 10:52314573-52314573

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.29C>A; p.T10N; 10:52314463-52314463

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.138C>T; p.P46P; 10:52314572-52314572

 skinmalignant_melanomaSubstitution - coding silent

c.367C>T; p.R123C; 10:52315046-52315046

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.109C>T; p.L37F; 10:52314543-52314543

 skinmalignant_melanomaSubstitution - Missense

c.189G>A; p.A63A; 10:52314623-52314623

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.316G>A; p.A106T; 10:52314995-52314995

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.372C>T; p.H124H; 10:52315051-52315051

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.368G>A; p.R123H; 10:52315047-52315047

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.442_443GG>AA; p.G148K; 10:52316330-52316331

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.680G>A; p.G227D; 10:52316686-52316686

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.244-7C>T; p.?; 10:52314916-52314916

 breastcarcinomaUnknown

c.673A>G; p.R225G; 10:52316679-52316679

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.619T>C; p.S207P; 10:52316625-52316625

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.221A>G; p.Y74C; 10:52314655-52314655

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

')