Entrez Gene

Basic Information
Gene ID	200186
Name	CRTC2
Synonymous	CREB regulated transcription coactivator 2;CRTC2;CREB regulated transcription coactivator 2
Definition	CREB-regulated transcription coactivator 2\|transducer of regulated cAMP response element-binding protein (CREB) 2
Position	1q21.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1876G>T; p.G626C; 1:153948315-153948315	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.246C>T; p.A82A; 1:153955074-153955074	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.246C>T; p.A82A; 1:153955074-153955074	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1800C>T; p.F600F; 1:153948519-153948519	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1327G>A; p.D443N; 1:153951337-153951337	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1327G>A; p.D443N; 1:153951337-153951337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1327G>A; p.D443N; 1:153951337-153951337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1282C>T; p.R428C; 1:153951382-153951382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1480G>C; p.V494L; 1:153949309-153949309	urinary_tract; bladder	carcinoma	Substitution - Missense
c.741C>T; p.V247V; 1:153952408-153952408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.861G>T; p.L287L; 1:153952154-153952154	central_nervous_system; brain	glioma	Substitution - coding silent
c.812C>T; p.T271M; 1:153952203-153952203	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.967A>G; p.M323V; 1:153952048-153952048	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.638-4C>T; p.?; 1:153952639-153952639	pancreas	carcinoma	Unknown
c.1124C>T; p.S375F; 1:153951540-153951540	thyroid	carcinoma	Substitution - Missense
c.1124C>T; p.S375F; 1:153951540-153951540	skin; extremity	malignant_melanoma	Substitution - Missense
c.1547C>T; p.S516L; 1:153949242-153949242	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.539T>A; p.M180K; 1:153953334-153953334	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.986A>G; p.Y329C; 1:153952029-153952029	pancreas	carcinoma	Substitution - Missense
c.1226C>T; p.P409L; 1:153951438-153951438	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1027C>A; p.L343M; 1:153951637-153951637	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.657C>T; p.N219N; 1:153952616-153952616	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.763T>A; p.S255T; 1:153952252-153952252	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.546C>T; p.P182P; 1:153953327-153953327	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1329C>T; p.D443D; 1:153951335-153951335	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.699G>C; p.K233N; 1:153952574-153952574	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1492C>G; p.Q498E; 1:153949297-153949297	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.590_591delTG; p.L197fs*11; 1:153953282-153953283	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.590_591delTG; p.L197fs*11; 1:153953282-153953283	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1132G>A; p.A378T; 1:153951532-153951532	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.657C>A; p.N219K; 1:153952616-153952616	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1293C>A; p.P431P; 1:153951371-153951371	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.971G>T; p.G324V; 1:153952044-153952044	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1826C>T; p.S609F; 1:153948493-153948493	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.598C>T; p.R200*; 1:153953275-153953275	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.1205C>T; p.S402F; 1:153951459-153951459	skin	malignant_melanoma	Substitution - Missense
c.761C>T; p.P254L; 1:153952254-153952254	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1205C>T; p.S402F; 1:153951459-153951459	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.633delC; p.V213fs*9; 1:153952809-153952809	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Deletion - Frameshift
c.2061C>T; p.F687F; 1:153948130-153948130	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.745G>A; p.G249R; 1:153952404-153952404	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1060G>T; p.A354S; 1:153951604-153951604	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2062C>T; p.R688C; 1:153948129-153948129	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1058A>G; p.Q353R; 1:153951606-153951606	skin	malignant_melanoma	Substitution - Missense
c.1742G>C; p.G581A; 1:153948577-153948577	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1523C>G; p.P508R; 1:153949266-153949266	thyroid	carcinoma; medullary_carcinoma	Substitution - Missense
c.814G>T; p.G272W; 1:153952201-153952201	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.814G>T; p.G272W; 1:153952201-153952201	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.814G>T; p.G272W; 1:153952201-153952201	large_intestine; colon	carcinoma	Substitution - Missense
c.814G>T; p.G272W; 1:153952201-153952201	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.228G>C; p.Q76H; 1:153955092-153955092	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1537C>G; p.Q513E; 1:153949252-153949252	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1136G>A; p.R379H; 1:153951528-153951528	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.774G>T; p.Q258H; 1:153952241-153952241	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1936G>C; p.A646P; 1:153948255-153948255	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1407C>T; p.G469G; 1:153949382-153949382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1950A>T; p.L650L; 1:153948241-153948241	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.439A>G; p.M147V; 1:153953602-153953602	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.244G>A; p.A82T; 1:153955076-153955076	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1451C>T; p.P484L; 1:153949338-153949338	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1268C>G; p.A423G; 1:153951396-153951396	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1026C>T; p.S342S; 1:153951638-153951638	skin	malignant_melanoma	Substitution - coding silent
c.1026C>T; p.S342S; 1:153951638-153951638	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1601C>T; p.P534L; 1:153949188-153949188	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1155C>G; p.T385T; 1:153951509-153951509	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1957G>T; p.G653W; 1:153948234-153948234	ovary	other; neoplasm	Substitution - Missense
c.463G>A; p.E155K; 1:153953578-153953578	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1212C>A; p.S404S; 1:153951452-153951452	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.295C>T; p.R99W; 1:153954950-153954950	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1958G>A; p.G653E; 1:153948233-153948233	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.938C>T; p.T313I; 1:153952077-153952077	skin	malignant_melanoma	Substitution - Missense
c.359G>T; p.R120L; 1:153954886-153954886	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1921T>G; p.F641V; 1:153948270-153948270	skin	malignant_melanoma	Substitution - Missense
c.1290G>A; p.V430V; 1:153951374-153951374	breast	carcinoma	Substitution - coding silent
c.1236C>T; p.G412G; 1:153951428-153951428	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.891C>T; p.A297A; 1:153952124-153952124	skin	malignant_melanoma	Substitution - coding silent
c.1428A>C; p.K476N; 1:153949361-153949361	skin	malignant_melanoma	Substitution - Missense
c.1982A>T; p.E661V; 1:153948209-153948209	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.317G>A; p.R106Q; 1:153954928-153954928	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1217C>A; p.T406N; 1:153951447-153951447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.694G>A; p.A232T; 1:153952579-153952579	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.728G>A; p.R243Q; 1:153952421-153952421	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1975C>T; p.R659C; 1:153948216-153948216	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1975C>T; p.R659C; 1:153948216-153948216	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1975C>T; p.R659C; 1:153948216-153948216	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.984C>T; p.G328G; 1:153952031-153952031	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2027C>T; p.A676V; 1:153948164-153948164	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1326C>T; p.A442A; 1:153951338-153951338	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1637C>T; p.S546F; 1:153949152-153949152	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1316C>T; p.A439V; 1:153951348-153951348	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.518C>G; p.S173C; 1:153953355-153953355	breast	carcinoma	Substitution - Missense
c.1811A>C; p.N604T; 1:153948508-153948508	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1444C>T; p.R482W; 1:153949345-153949345	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1367C>T; p.S456L; 1:153951297-153951297	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1367C>T; p.S456L; 1:153951297-153951297	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.512C>T; p.S171F; 1:153953361-153953361	skin	malignant_melanoma	Substitution - Missense
c.1761T>C; p.G587G; 1:153948558-153948558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.241C>T; p.L81L; 1:153955079-153955079	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1473A>T; p.P491P; 1:153949316-153949316	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.400T>C; p.Y134H; 1:153954289-153954289	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.102C>A; p.A34A; 1:153958396-153958396	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1798T>G; p.F600V; 1:153948521-153948521	stomach	adenocarcinoma	Substitution - Missense
c.67A>G; p.S23G; 1:153958431-153958431	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1868C>T; p.S623F; 1:153948323-153948323	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1032G>C; p.Q344H; 1:153951632-153951632	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1345C>T; p.Q449*; 1:153951319-153951319	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1345C>T; p.Q449*; 1:153951319-153951319	large_intestine; colon	carcinoma	Substitution - Nonsense
c.1728T>C; p.P576P; 1:153948591-153948591	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1056C>T; p.L352L; 1:153951608-153951608	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.359G>A; p.R120Q; 1:153954886-153954886	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.599G>A; p.R200Q; 1:153953274-153953274	NS	NS	Substitution - Missense
c.1703C>T; p.S568L; 1:153948616-153948616	skin	malignant_melanoma	Substitution - Missense
c.818_819insG; p.S274fs*4; 1:153952196-153952197	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2042C>G; p.P681R; 1:153948149-153948149	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.437C>T; p.T146M; 1:153953604-153953604	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1155C>T; p.T385T; 1:153951509-153951509	skin	malignant_melanoma	Substitution - coding silent
c.1780C>T; p.P594S; 1:153948539-153948539	skin	malignant_melanoma	Substitution - Missense
c.341T>C; p.M114T; 1:153954904-153954904	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.70G>A; p.E24K; 1:153958428-153958428	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1671G>A; p.G557G; 1:153949118-153949118	skin	malignant_melanoma	Substitution - coding silent
c.142G>T; p.G48C; 1:153958356-153958356	urinary_tract; bladder	carcinoma	Substitution - Missense
c.641C>T; p.P214L; 1:153952632-153952632	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.753C>T; p.N251N; 1:153952262-153952262	lung	carcinoma; adenocarcinoma	Substitution - coding silent

COSMIC somatic mutation [Top]