Entrez Gene

Basic Information
Gene ID	1912
Name	PHC2
Synonymous	polyhomeotic homolog 2 (Drosophila);PHC2;polyhomeotic homolog 2 (Drosophila)
Definition	early development regulator 2 (homolog of polyhomeotic 2)\|early development regulatory protein 2\|polyhomeotic 2\|polyhomeotic-like 2\|polyhomeotic-like protein 2
Position	1p34.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.828T>C; p.P276P; 1:33367264-33367264	thyroid	other; neoplasm	Substitution - coding silent
c.1756C>T; p.P586S; 1:33334092-33334092	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1254C>T; p.G418G; 1:33354976-33354976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1854C>T; p.T618T; 1:33332309-33332309	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1936G>T; p.G646C; 1:33331415-33331415	urinary_tract; bladder	carcinoma	Substitution - Missense
c.209C>T; p.T70M; 1:33372413-33372413	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2250G>C; p.L750F; 1:33329042-33329042	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.276G>A; p.A92A; 1:33372346-33372346	breast	carcinoma	Substitution - coding silent
c.516C>T; p.G172G; 1:33370481-33370481	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.6G>C; p.E2D; 1:33375534-33375534	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2153G>T; p.G718V; 1:33329139-33329139	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.6G>C; p.E2D; 1:33375534-33375534	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1985C>T; p.S662F; 1:33331366-33331366	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2393A>G; p.D798G; 1:33328899-33328899	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1758+2T>A; p.?; 1:33334088-33334088	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.2329C>T; p.R777W; 1:33328963-33328963	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1041A>T; p.Q347H; 1:33355189-33355189	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1940G>A; p.R647Q; 1:33331411-33331411	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1927G>A; p.E643K; 1:33331424-33331424	breast	carcinoma	Substitution - Missense
c.2011G>T; p.V671L; 1:33330205-33330205	breast	carcinoma	Substitution - Missense
c.235T>C; p.Y79H; 1:33372387-33372387	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2130G>T; p.K710N; 1:33330086-33330086	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.664-1G>A; p.?; 1:33367429-33367429	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.615G>A; p.Q205Q; 1:33368584-33368584	ovary	other; neoplasm	Substitution - coding silent
c.118C>T; p.P40S; 1:33375422-33375422	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1928A>C; p.E643A; 1:33331423-33331423	breast	carcinoma	Substitution - Missense
c.1082C>A; p.P361Q; 1:33355148-33355148	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.387G>T; p.A129A; 1:33371041-33371041	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.174+5G>T; p.?; 1:33375361-33375361	pancreas	carcinoma	Unknown
c.1423G>A; p.V475M; 1:33354533-33354533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1765C>T; p.R589C; 1:33332398-33332398	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1765C>T; p.R589C; 1:33332398-33332398	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1765C>T; p.R589C; 1:33332398-33332398	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2282G>C; p.R761P; 1:33329010-33329010	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.942T>A; p.V314V; 1:33367150-33367150	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.942T>A; p.V314V; 1:33367150-33367150	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2282G>C; p.R761P; 1:33329010-33329010	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.347C>A; p.S116Y; 1:33371081-33371081	liver	carcinoma	Substitution - Missense
c.347C>A; p.S116Y; 1:33371081-33371081	liver	carcinoma	Substitution - Missense
c.1931T>G; p.L644R; 1:33331420-33331420	skin	malignant_melanoma	Substitution - Missense
c.2463C>A; p.I821I; 1:33324979-33324979	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.961C>T; p.P321S; 1:33367131-33367131	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1719C>T; p.I573I; 1:33334129-33334129	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1719C>T; p.I573I; 1:33334129-33334129	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2028G>C; p.R676R; 1:33330188-33330188	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2168C>T; p.S723L; 1:33329124-33329124	pancreas	carcinoma	Substitution - Missense
c.1542G>A; p.P514P; 1:33354414-33354414	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1709C>T; p.T570M; 1:33334139-33334139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2168C>T; p.S723L; 1:33329124-33329124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2407A>G; p.I803V; 1:33328885-33328885	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.386C>T; p.A129V; 1:33371042-33371042	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.427T>C; p.S143P; 1:33370570-33370570	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1092G>A; p.Q364Q; 1:33355138-33355138	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.610G>C; p.V204L; 1:33368589-33368589	breast	carcinoma	Substitution - Missense
c.2534C>T; p.A845V; 1:33324908-33324908	skin	malignant_melanoma	Substitution - Missense
c.2248T>C; p.L750L; 1:33329044-33329044	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.270C>T; p.T90T; 1:33372352-33372352	central_nervous_system; brain	glioma	Substitution - coding silent
c.831A>G; p.A277A; 1:33367261-33367261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.760C>T; p.P254S; 1:33367332-33367332	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.760C>T; p.P254S; 1:33367332-33367332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.169G>A; p.V57M; 1:33375371-33375371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.169G>A; p.V57M; 1:33375371-33375371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1474C>T; p.H492Y; 1:33354482-33354482	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1540C>T; p.P514S; 1:33354416-33354416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.210G>A; p.T70T; 1:33372412-33372412	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1671T>A; p.N557K; 1:33334177-33334177	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2494G>T; p.D832Y; 1:33324948-33324948	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.210G>A; p.T70T; 1:33372412-33372412	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2467G>C; p.G823R; 1:33324975-33324975	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.958C>T; p.H320Y; 1:33367134-33367134	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1994G>A; p.C665Y; 1:33331357-33331357	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.236A>G; p.Y79C; 1:33372386-33372386	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1299G>C; p.Q433H; 1:33354931-33354931	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.771C>T; p.G257G; 1:33367321-33367321	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.771C>T; p.G257G; 1:33367321-33367321	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1620C>T; p.N540N; 1:33334228-33334228	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.573G>A; p.Q191Q; 1:33370424-33370424	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.115C>T; p.R39C; 1:33375425-33375425	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.193C>T; p.H65Y; 1:33372429-33372429	liver	carcinoma	Substitution - Missense
c.193C>T; p.H65Y; 1:33372429-33372429	liver	carcinoma	Substitution - Missense
c.1910C>T; p.P637L; 1:33331441-33331441	skin	malignant_melanoma	Substitution - Missense
c.2449C>T; p.R817C; 1:33324993-33324993	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2078C>T; p.A693V; 1:33330138-33330138	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2078C>T; p.A693V; 1:33330138-33330138	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1357G>A; p.A453T; 1:33354873-33354873	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2298G>T; p.Q766H; 1:33328994-33328994	prostate	carcinoma	Substitution - Missense
c.37A>G; p.S13G; 1:33375503-33375503	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.241G>A; p.A81T; 1:33372381-33372381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1908delT; p.L638fs*93; 1:33331443-33331443	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2079G>A; p.A693A; 1:33330137-33330137	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.32C>A; p.S11Y; 1:33375508-33375508	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1344C>G; p.F448L; 1:33354886-33354886	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2466C>G; p.D822E; 1:33324976-33324976	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2533G>A; p.A845T; 1:33324909-33324909	liver	carcinoma	Substitution - Missense
c.2533G>A; p.A845T; 1:33324909-33324909	liver	carcinoma	Substitution - Missense
c.1814_1815insGGGTT; p.F605fs*128; 1:33332348-33332349	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.2496C>G; p.D832E; 1:33324946-33324946	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.818A>G; p.Q273R; 1:33367274-33367274	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2547C>T; p.Y849Y; 1:33324895-33324895	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2547C>T; p.Y849Y; 1:33324895-33324895	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.325G>A; p.V109I; 1:33372297-33372297	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.201G>A; p.Q67Q; 1:33372421-33372421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1152C>T; p.S384S; 1:33355078-33355078	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1759-7C>G; p.?; 1:33332411-33332411	liver	carcinoma	Unknown
c.1966C>T; p.R656C; 1:33331385-33331385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1152C>T; p.S384S; 1:33355078-33355078	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1759-7C>G; p.?; 1:33332411-33332411	liver	carcinoma	Unknown
c.917G>A; p.G306D; 1:33367175-33367175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1880A>G; p.Y627C; 1:33332283-33332283	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2325T>C; p.H775H; 1:33328967-33328967	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2495A>T; p.D832V; 1:33324947-33324947	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2260T>G; p.S754A; 1:33329032-33329032	central_nervous_system; thalamus	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2275A>C; p.T759P; 1:33329017-33329017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.237C>T; p.Y79Y; 1:33372385-33372385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1722A>C; p.E574D; 1:33334126-33334126	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.396G>A; p.P132P; 1:33371032-33371032	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2501T>C; p.L834P; 1:33324941-33324941	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2040C>T; p.F680F; 1:33330176-33330176	skin	malignant_melanoma	Substitution - coding silent
c.1566G>C; p.Q522H; 1:33334282-33334282	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1524G>A; p.T508T; 1:33354432-33354432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2040C>T; p.F680F; 1:33330176-33330176	skin	malignant_melanoma	Substitution - coding silent
c.892A>C; p.S298R; 1:33367200-33367200	skin	malignant_melanoma	Substitution - Missense
c.2246C>G; p.P749R; 1:33329046-33329046	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1815C>T; p.F605F; 1:33332348-33332348	skin	malignant_melanoma	Substitution - coding silent
c.584T>C; p.F195S; 1:33368615-33368615	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2276C>A; p.T759N; 1:33329016-33329016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.375C>T; p.S125S; 1:33371053-33371053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.162G>A; p.R54R; 1:33375378-33375378	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.63C>T; p.S21S; 1:33375477-33375477	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.481G>A; p.A161T; 1:33370516-33370516	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.481G>A; p.A161T; 1:33370516-33370516	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.130C>A; p.Q44K; 1:33375410-33375410	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2095C>T; p.R699W; 1:33330121-33330121	breast	carcinoma	Substitution - Missense
c.2095C>T; p.R699W; 1:33330121-33330121	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1862C>T; p.S621L; 1:33332301-33332301	breast	carcinoma	Substitution - Missense
c.1912delC; p.L638fs*93; 1:33331439-33331439	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1704C>T; p.I568I; 1:33334144-33334144	skin	malignant_melanoma	Substitution - coding silent
c.2497C>A; p.H833N; 1:33324945-33324945	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1217C>A; p.P406Q; 1:33355013-33355013	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1683G>T; p.Q561H; 1:33334165-33334165	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2034A>G; p.G678G; 1:33330182-33330182	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1683G>T; p.Q561H; 1:33334165-33334165	large_intestine; colon	carcinoma	Substitution - Missense
c.562C>T; p.L188L; 1:33370435-33370435	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.355C>A; p.Q119K; 1:33371073-33371073	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.355C>A; p.Q119K; 1:33371073-33371073	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.271G>A; p.A91T; 1:33372351-33372351	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2538G>A; p.L846L; 1:33324904-33324904	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2538G>A; p.L846L; 1:33324904-33324904	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1398G>T; p.Q466H; 1:33354558-33354558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1556-7C>T; p.?; 1:33334299-33334299	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1437G>A; p.E479E; 1:33354519-33354519	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1909C>T; p.P637S; 1:33331442-33331442	skin	malignant_melanoma	Substitution - Missense
c.168C>T; p.T56T; 1:33375372-33375372	skin	malignant_melanoma	Substitution - coding silent
c.2299C>T; p.R767W; 1:33328993-33328993	ovary	other; neoplasm	Substitution - Missense
c.2158G>A; p.V720M; 1:33329134-33329134	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1820C>T; p.P607L; 1:33332343-33332343	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.116G>A; p.R39H; 1:33375424-33375424	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.938C>T; p.T313M; 1:33367154-33367154	liver	carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]