Entrez Gene

Basic Information
Gene ID	183
Name	AGT
Synonymous	angiotensinogen (serpin peptidase inhibitor, clade A, member 8);AGT;angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Definition	alpha-1 antiproteinase, antitrypsin\|angiotensin I\|angiotensin II\|angiotensinogen\|pre-angiotensinogen\|serine (or cysteine) proteinase inhibitor\|serpin A8
Position	1q42.2
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.257A>T; p.D86V; 1:230710594-230710594	breast	carcinoma	Substitution - Missense
c.396C>A; p.T132T; 1:230710455-230710455	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1122C>T; p.P374P; 1:230705935-230705935	skin	malignant_melanoma	Substitution - coding silent
c.1096C>A; p.L366I; 1:230705961-230705961	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.260A>T; p.Q87L; 1:230710591-230710591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.941C>G; p.S314C; 1:230706116-230706116	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.834C>G; p.F278L; 1:230710017-230710017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.932_933CC>TT; p.P311L; 1:230706124-230706125	skin	malignant_melanoma	Substitution - Missense
c.987C>T; p.F329F; 1:230706070-230706070	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1015A>G; p.S339G; 1:230706042-230706042	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1015A>G; p.S339G; 1:230706042-230706042	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.165A>G; p.A55A; 1:230710686-230710686	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.93T>C; p.A31A; 1:230710758-230710758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1407C>A; p.A469A; 1:230703192-230703192	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1291G>T; p.E431*; 1:230703308-230703308	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.111C>T; p.Y37Y; 1:230710740-230710740	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.551T>C; p.L184P; 1:230710300-230710300	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.900C>A; p.F300L; 1:230706157-230706157	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1435G>T; p.A479S; 1:230703164-230703164	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1435G>T; p.A479S; 1:230703164-230703164	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1435G>T; p.A479S; 1:230703164-230703164	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.787A>C; p.T263P; 1:230710064-230710064	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.379G>A; p.V127M; 1:230710472-230710472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.666G>A; p.P222P; 1:230710185-230710185	pancreas	carcinoma	Substitution - coding silent
c.346C>T; p.R116C; 1:230710505-230710505	skin	malignant_melanoma	Substitution - Missense
c.323T>C; p.M108T; 1:230710528-230710528	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.620C>T; p.T207M; 1:230710231-230710231	skin	malignant_melanoma	Substitution - Missense
c.190G>T; p.D64Y; 1:230710661-230710661	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.190G>T; p.D64Y; 1:230710661-230710661	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.378C>T; p.G126G; 1:230710473-230710473	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.638C>A; p.T213K; 1:230710213-230710213	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1076T>A; p.L359H; 1:230705981-230705981	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1417C>T; p.H473Y; 1:230703182-230703182	prostate	carcinoma	Substitution - Missense
c.1329C>A; p.T443T; 1:230703270-230703270	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.520C>A; p.R174R; 1:230710331-230710331	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.211C>A; p.P71T; 1:230710640-230710640	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.466G>C; p.D156H; 1:230710385-230710385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.221C>T; p.A74V; 1:230710630-230710630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.520C>A; p.R174R; 1:230710331-230710331	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.211C>A; p.P71T; 1:230710640-230710640	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.412G>A; p.A138T; 1:230710439-230710439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.412G>A; p.A138T; 1:230710439-230710439	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.657G>A; p.L219L; 1:230710194-230710194	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1012G>A; p.E338K; 1:230706045-230706045	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1290delT; p.F430fs*25; 1:230703309-230703309	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1290delT; p.F430fs*25; 1:230703309-230703309	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.894G>A; p.Q298Q; 1:230706163-230706163	skin	malignant_melanoma	Substitution - coding silent
c.1290delT; p.F430fs*25; 1:230703309-230703309	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1290delT; p.F430fs*25; 1:230703309-230703309	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1290delT; p.F430fs*25; 1:230703309-230703309	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1290delT; p.F430fs*25; 1:230703309-230703309	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1290delT; p.F430fs*25; 1:230703309-230703309	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1052C>G; p.S351C; 1:230706005-230706005	breast	carcinoma	Substitution - Missense
c.532C>T; p.H178Y; 1:230710319-230710319	prostate	carcinoma	Substitution - Missense
c.1321G>A; p.E441K; 1:230703278-230703278	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1372C>T; p.R458C; 1:230703227-230703227	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.417C>T; p.V139V; 1:230710434-230710434	skin	malignant_melanoma	Substitution - coding silent
c.692C>T; p.T231I; 1:230710159-230710159	liver	carcinoma	Substitution - Missense
c.1290_1291insT; p.E431fs*1; 1:230703308-230703309	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1290_1291insT; p.E431fs*1; 1:230703308-230703309	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.478G>A; p.A160T; 1:230710373-230710373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.478G>A; p.A160T; 1:230710373-230710373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.357C>A; p.G119G; 1:230710494-230710494	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.34C>T; p.P12S; 1:230710817-230710817	skin	malignant_melanoma	Substitution - Missense
c.1280G>A; p.S427N; 1:230703319-230703319	skin	malignant_melanoma	Substitution - Missense
c.362A>T; p.H121L; 1:230710489-230710489	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.664C>T; p.P222S; 1:230710187-230710187	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1347T>A; p.P449P; 1:230703252-230703252	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.559G>T; p.V187L; 1:230710292-230710292	breast	carcinoma	Substitution - Missense
c.626T>C; p.V209A; 1:230710225-230710225	skin	malignant_melanoma	Substitution - Missense
c.1149A>G; p.Q383Q; 1:230704313-230704313	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1411G>A; p.A471T; 1:230703188-230703188	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.978G>A; p.Q326Q; 1:230706079-230706079	skin	malignant_melanoma	Substitution - coding silent
c.11G>T; p.R4L; 1:230710840-230710840	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.692C>A; p.T231N; 1:230710159-230710159	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.307G>A; p.A103T; 1:230710544-230710544	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.183G>T; p.K61N; 1:230710668-230710668	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1268A>C; p.E423A; 1:230704194-230704194	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.318C>T; p.V106V; 1:230710533-230710533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.530C>T; p.A177V; 1:230710321-230710321	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.318C>T; p.V106V; 1:230710533-230710533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.530C>T; p.A177V; 1:230710321-230710321	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.318C>T; p.V106V; 1:230710533-230710533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.318C>T; p.V106V; 1:230710533-230710533	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.201C>T; p.F67F; 1:230710650-230710650	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.390G>T; p.G130G; 1:230710461-230710461	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.612G>T; p.L204L; 1:230710239-230710239	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1006T>A; p.F336I; 1:230706051-230706051	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.57C>T; p.A19A; 1:230710794-230710794	pancreas	carcinoma	Substitution - coding silent
c.57C>T; p.A19A; 1:230710794-230710794	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.57C>T; p.A19A; 1:230710794-230710794	pancreas	carcinoma	Substitution - coding silent
c.57C>T; p.A19A; 1:230710794-230710794	pancreas	carcinoma	Substitution - coding silent
c.4C>T; p.R2W; 1:230710847-230710847	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1101C>T; p.N367N; 1:230705956-230705956	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.895G>A; p.E299K; 1:230706162-230706162	skin	malignant_melanoma	Substitution - Missense
c.895G>A; p.E299K; 1:230706162-230706162	skin	malignant_melanoma	Substitution - Missense
c.1254C>T; p.R418R; 1:230704208-230704208	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.937C>T; p.L313F; 1:230706120-230706120	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.226A>G; p.T76A; 1:230710625-230710625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.522G>T; p.R174R; 1:230710329-230710329	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.914G>A; p.S305N; 1:230706143-230706143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.775A>C; p.T259P; 1:230710076-230710076	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1110G>A; p.K370K; 1:230705947-230705947	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.750G>A; p.K250K; 1:230710101-230710101	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1253G>A; p.R418H; 1:230704209-230704209	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1190C>T; p.A397V; 1:230704272-230704272	skin	malignant_melanoma	Substitution - Missense
c.803T>C; p.M268T; 1:230710048-230710048	skin	malignant_melanoma	Substitution - Missense
c.803T>C; p.M268T; 1:230710048-230710048	breast	carcinoma	Substitution - Missense
c.803T>C; p.M268T; 1:230710048-230710048	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1423C>T; p.L475L; 1:230703176-230703176	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.351A>G; p.I117M; 1:230710500-230710500	liver	carcinoma	Substitution - Missense
c.351A>G; p.I117M; 1:230710500-230710500	liver	carcinoma	Substitution - Missense
c.939C>T; p.L313L; 1:230706118-230706118	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1247A>G; p.N416S; 1:230704215-230704215	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.667T>C; p.F223L; 1:230710184-230710184	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1298A>C; p.E433A; 1:230703301-230703301	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.284T>C; p.L95P; 1:230710567-230710567	stomach	adenocarcinoma	Substitution - Missense
c.1271T>C; p.V424A; 1:230703328-230703328	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1110G>T; p.K370N; 1:230705947-230705947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1271T>C; p.V424A; 1:230703328-230703328	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.31G>A; p.A11T; 1:230710820-230710820	urinary_tract; bladder	carcinoma	Substitution - Missense
c.517T>C; p.S173P; 1:230710334-230710334	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1210_1211insGCC; p.I404>SL; 1:230704251-230704252	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Complex - insertion inframe
c.1123C>T; p.R375W; 1:230705934-230705934	skin	malignant_melanoma	Substitution - Missense
c.251T>C; p.L84P; 1:230710600-230710600	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1432G>A; p.V478M; 1:230703167-230703167	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1277A>G; p.N426S; 1:230703322-230703322	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.665C>T; p.P222L; 1:230710186-230710186	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1126A>T; p.T376S; 1:230704336-230704336	liver	carcinoma	Substitution - Missense
c.1313_1314delAG; p.E438fs*9; 1:230703285-230703286	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1126A>T; p.T376S; 1:230704336-230704336	liver	carcinoma	Substitution - Missense
c.466G>A; p.D156N; 1:230710385-230710385	urinary_tract; bladder	carcinoma	Substitution - Missense
c.466G>A; p.D156N; 1:230710385-230710385	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense

COSMIC somatic mutation [Top]