Entrez Gene

Basic Information
Gene ID	10525
Name	HYOU1
Synonymous	hypoxia up-regulated 1;HYOU1;hypoxia up-regulated 1
Definition	150 kDa oxygen-regulated protein\|170 kDa glucose-regulated protein\|hypoxia up-regulated protein 1\|oxygen regulated protein (150kD)
Position	11q23.1-q23.3
Gene Type	protein-coding

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1489T>C; p.Y497H; 11:119051475-119051475	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2610A>G; p.A870A; 11:119046788-119046788	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2272G>A; p.E758K; 11:119048352-119048352	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2690C>T; p.A897V; 11:119046708-119046708	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2690C>T; p.A897V; 11:119046708-119046708	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1385T>C; p.L462P; 11:119051579-119051579	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1542G>T; p.Q514H; 11:119051158-119051158	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2091G>T; p.E697D; 11:119048788-119048788	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2091G>T; p.E697D; 11:119048788-119048788	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2091G>T; p.E697D; 11:119048788-119048788	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2975G>A; p.R992Q; 11:119045618-119045618	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.811G>T; p.G271W; 11:119052813-119052813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2991C>T; p.D997D; 11:119045602-119045602	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.216G>C; p.V72V; 11:119055541-119055541	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1447A>T; p.T483S; 11:119051517-119051517	pancreas	carcinoma	Substitution - Missense
c.131C>T; p.S44F; 11:119055804-119055804	skin	malignant_melanoma	Substitution - Missense
c.1813G>A; p.E605K; 11:119049197-119049197	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1414C>T; p.R472W; 11:119051550-119051550	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.320A>G; p.Q107R; 11:119055284-119055284	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1414C>T; p.R472W; 11:119051550-119051550	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.1813G>A; p.E605K; 11:119049197-119049197	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1414C>T; p.R472W; 11:119051550-119051550	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1715C>G; p.S572C; 11:119049788-119049788	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.2019G>T; p.G673G; 11:119048860-119048860	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1186C>T; p.L396L; 11:119052109-119052109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.556C>T; p.R186*; 11:119054616-119054616	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1246G>A; p.A416T; 11:119051911-119051911	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1476C>T; p.N492N; 11:119051488-119051488	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1033C>T; p.R345C; 11:119052384-119052384	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1526G>A; p.R509Q; 11:119051438-119051438	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2378T>C; p.M793T; 11:119048079-119048079	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.788G>A; p.G263E; 11:119054127-119054127	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.892G>C; p.D298H; 11:119052732-119052732	urinary_tract; bladder	carcinoma	Substitution - Missense
c.654G>A; p.R218R; 11:119054518-119054518	skin	malignant_melanoma	Substitution - coding silent
c.415A>T; p.S139C; 11:119055189-119055189	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.283G>A; p.A95T; 11:119055321-119055321	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.621C>T; p.T207T; 11:119054551-119054551	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2815G>A; p.E939K; 11:119046583-119046583	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.531A>G; p.P177P; 11:119054641-119054641	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1178A>G; p.Q393R; 11:119052117-119052117	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1842C>T; p.D614D; 11:119049168-119049168	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.441G>T; p.E147D; 11:119055039-119055039	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2097C>T; p.I699I; 11:119048782-119048782	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1275G>A; p.A425A; 11:119051882-119051882	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1787A>G; p.N596S; 11:119049575-119049575	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.287C>T; p.T96M; 11:119055317-119055317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2048G>C; p.G683A; 11:119048831-119048831	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2834C>T; p.A945V; 11:119046564-119046564	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.370G>A; p.E124K; 11:119055234-119055234	breast	carcinoma	Substitution - Missense
c.1603G>A; p.E535K; 11:119051097-119051097	prostate	carcinoma	Substitution - Missense
c.932G>A; p.R311H; 11:119052692-119052692	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Missense
c.2078G>C; p.R693P; 11:119048801-119048801	breast	carcinoma	Substitution - Missense
c.2692C>T; p.L898L; 11:119046706-119046706	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1205+1G>T; p.?; 11:119052089-119052089	lung	carcinoma; adenocarcinoma	Unknown
c.2749C>T; p.R917W; 11:119046649-119046649	breast	carcinoma	Substitution - Missense
c.2234C>T; p.A745V; 11:119048495-119048495	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.910C>T; p.R304C; 11:119052714-119052714	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.341C>A; p.A114D; 11:119055263-119055263	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2332G>A; p.A778T; 11:119048292-119048292	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2332G>A; p.A778T; 11:119048292-119048292	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2698C>T; p.R900*; 11:119046700-119046700	skin; extremity	malignant_melanoma	Substitution - Nonsense
c.2068G>A; p.A690T; 11:119048811-119048811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2986A>G; p.N996D; 11:119045607-119045607	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.352G>T; p.A118S; 11:119055252-119055252	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.462C>T; p.L154L; 11:119055018-119055018	skin	malignant_melanoma	Substitution - coding silent
c.2043A>G; p.P681P; 11:119048836-119048836	thyroid	other; neoplasm	Substitution - coding silent
c.1439A>G; p.K480R; 11:119051525-119051525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2011G>A; p.E671K; 11:119048868-119048868	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2343G>A; p.W781*; 11:119048281-119048281	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.622G>A; p.A208T; 11:119054550-119054550	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1670A>C; p.E557A; 11:119049833-119049833	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2841G>T; p.Q947H; 11:119046463-119046463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2841G>T; p.Q947H; 11:119046463-119046463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2841G>T; p.Q947H; 11:119046463-119046463	large_intestine; colon	carcinoma	Substitution - Missense
c.2841G>T; p.Q947H; 11:119046463-119046463	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1679T>C; p.F560S; 11:119049824-119049824	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1096G>A; p.A366T; 11:119052321-119052321	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.844C>T; p.R282C; 11:119052780-119052780	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1709A>C; p.E570A; 11:119049794-119049794	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1907C>T; p.P636L; 11:119049103-119049103	skin	malignant_melanoma	Substitution - Missense
c.202delA; p.T68fs*3; 11:119055555-119055555	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2424G>T; p.L808L; 11:119048033-119048033	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2572G>C; p.E858Q; 11:119047757-119047757	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.1823C>T; p.P608L; 11:119049187-119049187	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1494C>T; p.G498G; 11:119051470-119051470	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.371A>T; p.E124V; 11:119055233-119055233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1647C>T; p.G549G; 11:119051053-119051053	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1421G>A; p.G474E; 11:119051543-119051543	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1647C>T; p.G549G; 11:119051053-119051053	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2458G>A; p.E820K; 11:119047999-119047999	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.171A>C; p.E57D; 11:119055764-119055764	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2458G>A; p.E820K; 11:119047999-119047999	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2978C>A; p.P993H; 11:119045615-119045615	liver	carcinoma	Substitution - Missense
c.522C>G; p.I174M; 11:119054650-119054650	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1510G>T; p.G504W; 11:119051454-119051454	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2888G>T; p.G963V; 11:119045831-119045831	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2191C>A; p.L731M; 11:119048538-119048538	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1074G>T; p.R358R; 11:119052343-119052343	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2506C>T; p.L836F; 11:119047951-119047951	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.182A>G; p.N61S; 11:119055753-119055753	liver	carcinoma	Substitution - Missense
c.1726+8G>A; p.?; 11:119049769-119049769	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Unknown
c.1726+8G>A; p.?; 11:119049769-119049769	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Unknown
c.549C>T; p.A183A; 11:119054623-119054623	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.286A>G; p.T96A; 11:119055318-119055318	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1766C>T; p.T589I; 11:119049596-119049596	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.898C>T; p.R300W; 11:119052726-119052726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.472C>T; p.R158C; 11:119055008-119055008	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2287delT; p.S763fs*30; 11:119048337-119048337	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.472C>T; p.R158C; 11:119055008-119055008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2140G>A; p.D714N; 11:119048739-119048739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1854G>A; p.E618E; 11:119049156-119049156	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1179G>A; p.Q393Q; 11:119052116-119052116	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1216G>C; p.G406R; 11:119051941-119051941	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.400G>T; p.V134L; 11:119055204-119055204	breast	carcinoma	Substitution - Missense
c.2653G>A; p.V885M; 11:119046745-119046745	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.969C>T; p.N323N; 11:119052655-119052655	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2042C>T; p.P681L; 11:119048837-119048837	thyroid	other; neoplasm	Substitution - Missense
c.2084T>C; p.M695T; 11:119048795-119048795	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1424C>T; p.P475L; 11:119051540-119051540	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1436G>A; p.R479H; 11:119051528-119051528	breast	carcinoma	Substitution - Missense
c.2080C>T; p.R694*; 11:119048799-119048799	pancreas	carcinoma	Substitution - Nonsense
c.884G>T; p.R295I; 11:119052740-119052740	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1914C>T; p.P638P; 11:119049096-119049096	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2080C>T; p.R694*; 11:119048799-119048799	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.380delT; p.F127fs*34; 11:119055224-119055224	liver	carcinoma	Deletion - Frameshift
c.313G>A; p.G105R; 11:119055291-119055291	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.125G>A; p.S42N; 11:119055810-119055810	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.206C>T; p.P69L; 11:119055551-119055551	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.332C>G; p.P111R; 11:119055272-119055272	skin	malignant_melanoma	Substitution - Missense
c.1008T>C; p.D336D; 11:119052409-119052409	pancreas	carcinoma	Substitution - coding silent
c.1400G>A; p.R467Q; 11:119051564-119051564	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1501G>T; p.G501C; 11:119051463-119051463	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.240C>A; p.F80L; 11:119055517-119055517	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.248A>G; p.D83G; 11:119055509-119055509	breast	carcinoma	Substitution - Missense
c.1892A>C; p.E631A; 11:119049118-119049118	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2515_2516insG; p.A839fs*13; 11:119047813-119047814	skin; ankle	malignant_melanoma; acral_lentiginous	Insertion - Frameshift
c.2515_2516insG; p.A839fs*13; 11:119047813-119047814	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1136A>C; p.Q379P; 11:119052159-119052159	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2515_2516insG; p.A839fs*13; 11:119047813-119047814	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.542A>G; p.N181S; 11:119054630-119054630	liver	carcinoma	Substitution - Missense
c.1198G>A; p.V400M; 11:119052097-119052097	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.542A>G; p.N181S; 11:119054630-119054630	liver	carcinoma	Substitution - Missense
c.2157G>A; p.S719S; 11:119048722-119048722	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2050G>C; p.E684Q; 11:119048829-119048829	NS	NS	Substitution - Missense
c.24G>A; p.Q8Q; 11:119056137-119056137	breast	carcinoma	Substitution - coding silent
c.2156C>T; p.S719L; 11:119048723-119048723	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1910delC; p.P637fs*60; 11:119049100-119049100	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2431C>T; p.R811W; 11:119048026-119048026	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.133A>G; p.M45V; 11:119055802-119055802	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1683G>C; p.E561D; 11:119049820-119049820	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.2992G>A; p.E998K; 11:119045601-119045601	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1962A>C; p.E654D; 11:119049048-119049048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2067C>T; p.P689P; 11:119048812-119048812	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1308C>T; p.V436V; 11:119051849-119051849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2881G>T; p.E961*; 11:119046423-119046423	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2245G>C; p.E749Q; 11:119048484-119048484	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.833G>T; p.R278L; 11:119052791-119052791	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.833G>T; p.R278L; 11:119052791-119052791	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2933G>T; p.G978V; 11:119045786-119045786	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2368A>G; p.T790A; 11:119048256-119048256	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2029G>A; p.V677I; 11:119048850-119048850	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2892C>T; p.S964S; 11:119045827-119045827	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.186-2A>G; p.?; 11:119055573-119055573	pancreas	carcinoma	Unknown
c.186-2A>G; p.?; 11:119055573-119055573	pancreas	carcinoma	Unknown

COSMIC somatic mutation [Top]