| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1030 |
Name | CDKN2B |
Synonymous | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4);CDKN2B;cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
Definition | CDK inhibitory protein|CDK4B inhibitor|MTS-2|cyclin-dependent kinase 4 inhibitor B|cyclin-dependent kinases 4 and 6 binding protein|multiple tumor suppressor 2|p14-INK4b|p14_CDK inhibitor|p14_INK4B|p15 CDK inhibitor|p15-INK4b|p15_INK4B |
Position | 9p21 |
Gene Type | protein-coding |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.20G>A; p.G7D; 9:22008934-22008934 |
oesophagus | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.210G>A; p.A70A; 9:22006194-22006194 |
skin | malignant_melanoma | Substitution - coding silent |
c.204C>T; p.H68H; 9:22006200-22006200 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.335G>T; p.W112L; 9:22006069-22006069 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.159C>T; p.V53V; 9:22006245-22006245 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - coding silent |
c.18G>C; p.K6N; 9:22008936-22008936 |
pancreas | other; pancreatoblastoma | Substitution - Missense |
c.227A>C; p.D76A; 9:22006177-22006177 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.181G>A; p.V61M; 9:22006223-22006223 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.225A>C; p.A75A; 9:22006179-22006179 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.118C>T; p.P40S; 9:22008836-22008836 |
liver | carcinoma | Substitution - Missense |
c.118C>T; p.P40S; 9:22008836-22008836 |
liver | carcinoma | Substitution - Missense |
c.179G>A; p.R60H; 9:22006225-22006225 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.82G>C; p.E28Q; 9:22008872-22008872 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.313C>T; p.R105W; 9:22006091-22006091 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.33G>A; p.G11G; 9:22008921-22008921 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.178_236del59; p.R60fs*7; 9:22006168-22006226 |
stomach | carcinoma; intestinal_adenocarcinoma | Deletion - Frameshift |
c.178C>T; p.R60C; 9:22006226-22006226 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.19G>T; p.G7C; 9:22008935-22008935 |
oesophagus | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.367C>T; p.R123W; 9:22006037-22006037 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.63C>T; p.A21A; 9:22008891-22008891 |
pancreas | carcinoma | Substitution - coding silent |
c.359C>A; p.A120D; 9:22006045-22006045 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.56C>A; p.A19D; 9:22008898-22008898 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; myelodysplastic_syndrome | Substitution - Missense |
c.5G>A; p.R2H; 9:22008949-22008949 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; myelodysplastic_syndrome | Substitution - Missense |
c.237T>C; p.T79T; 9:22006167-22006167 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |