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Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

4193

Name

MDM2

Synonymous

MDM2 proto-oncogene, E3 ubiquitin protein ligase;MDM2;MDM2 proto-oncogene, E3 ubiquitin protein ligase

Definition

E3 ubiquitin-protein ligase Mdm2|MDM2 oncogene, E3 ubiquitin protein ligase|Mdm2, p53 E3 ubiquitin protein ligase homolog|Mdm2, transformed 3T3 cell double minute 2, p53 binding protein|double minute 2, human homolog of; p53-binding protein|oncoprotein Md

Position

12q14.3-q15

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 DLG4REACTOME;

in same component

 KAT5NCI_NATURE;

in same component

 RPL5NCI_NATURE;

in same component

 TRIM28NCI_NATURE;

in same component

 UBE2D1NCI_NATURE;

in same component

 YY1NCI_NATURE;

interacts with

 ABL1BIOGRID;

interacts with

 ADRB2BIOGRID;

interacts with

 ADRB2HPRD;

interacts with

 ADRBK1HPRD;

interacts with

 ADRBK1MINT;

interacts with

 AKT1BIOGRID;

interacts with

 AKT1HPRD;

interacts with

 AKT1INTACT;

interacts with

 AKT1MINT;

interacts with

 ARBIOGRID;

interacts with

 ARCELL_MAP;

interacts with

 ARHPRD;

interacts with

 ARRB1BIOGRID;

interacts with

 ARRB2BIOGRID;

interacts with

 ARRB2HPRD;

interacts with

 ARRB2MINT;

interacts with

 ATF3BIOGRID;

interacts with

 ATMHPRD;

interacts with

 BANPBIOGRID;

interacts with

 BHLHE40MINT;

interacts with

 CA11BIOGRID;

interacts with

 CASP2BIOGRID;

interacts with

 CASP3HPRD;

interacts with

 CCAR1BIOGRID;

interacts with

 CCAR1HPRD;

interacts with

 CCNG1BIOGRID;

interacts with

 CCNG1HPRD;

interacts with

 CDH1BIOGRID;

interacts with

 CDKN1ABIOGRID;

interacts with

 CDKN1AHPRD;

interacts with

 Cdkn2aBIOGRID;

interacts with

 CDKN2ABIOGRID;

interacts with

 CDKN2AHPRD;

interacts with

 CDKN2AMINT;

interacts with

 CHEK2BIOGRID;

interacts with

 CHEK2HPRD;

interacts with

 CHEK2MINT;

interacts with

 COPS5BIOGRID;

interacts with

 COPS5HPRD;

interacts with

 CREBBPHPRD;

interacts with

 CTBP1BIOGRID;

interacts with

 CTBP2BIOGRID;

interacts with

 CTBP2HPRD;

interacts with

 DAXXBIOGRID;

interacts with

 DAXXHPRD;

interacts with

 DAXXMINT;

interacts with

 DDX17BIOGRID;

interacts with

 DHFRBIOGRID;

interacts with

 DHFRHPRD;

interacts with

 E2F1BIOGRID;

interacts with

 E2F1HPRD;

interacts with

 EHMT1BIOGRID;

interacts with

 EID1BIOGRID;

interacts with

 EID1HPRD;

interacts with

 EP300BIOGRID;

interacts with

 EP300HPRD;

interacts with

 ESR1BIOGRID;

interacts with

 ESR1HPRD;

interacts with

 FKBP3BIOGRID;

interacts with

 Fkbp3MINT;

interacts with

 FKBP3MINT;

interacts with

 FOXO4BIOGRID;

interacts with

 G3BP2BIOGRID;

interacts with

 GATA3BIOGRID;

interacts with

 GNASBIOGRID;

interacts with

 GNL2INTACT;

interacts with

 GNL3LINTACT;

interacts with

 GNL3BIOGRID;

interacts with

 GNL3INTACT;

interacts with

 GSK3BINTACT;

interacts with

 GTF2E1BIOGRID;

interacts with

 GTF2E2HPRD;

interacts with

 HDAC1BIOGRID;

interacts with

 HIF1ABIOGRID;

interacts with

 HIF1AHPRD;

interacts with

 HIPK2HPRD;

interacts with

 HIPK2MINT;

interacts with

 HIST2H2BEBIOGRID;

interacts with

 HIST3H3BIOGRID;

interacts with

 IGF1RBIOGRID;

interacts with

 IGF1RHPRD;

interacts with

 JMYHPRD;

interacts with

 JMYMINT;

interacts with

 KAT2BBIOGRID;

interacts with

 KAT2BHPRD;

interacts with

 KAT5BIOGRID;

interacts with

 MDC1BIOGRID;

interacts with

 MDM4BIOGRID;

interacts with

 MDM4HPRD;

interacts with

 MDM4MINT;

interacts with

 MED1HPRD;

interacts with

 MED1MINT;

interacts with

 MTA1BIOGRID;

interacts with

 MTBPBIOGRID;

interacts with

 MTBPHPRD;

interacts with

 NCLBIOGRID;

interacts with

 NR3C1BIOGRID;

interacts with

 NR3C1HPRD;

interacts with

 NUMBBIOGRID;

interacts with

 NUMBHPRD;

interacts with

 PAK1IP1BIOGRID;

interacts with

 PCNABIOGRID;

interacts with

 PIAS1HPRD;

interacts with

 PIM1MINT;

interacts with

 PIM2MINT;

interacts with

 PIM3MINT;

interacts with

 PJA1HPRD;

interacts with

 PLK1MINT;

interacts with

 POLEHPRD;

interacts with

 PPM1DBIOGRID;

interacts with

 PPM1DHPRD;

interacts with

 PSMD10BIOGRID;

interacts with

 PSMD10HPRD;

interacts with

 PSMD2BIOGRID;

interacts with

 PSME3BIOGRID;

interacts with

 PSME3HPRD;

interacts with

 PSME3MINT;

interacts with

 PTK2BIOGRID;

interacts with

 PYHIN1BIOGRID;

interacts with

 RAD23ABIOGRID;

interacts with

 RANBP2HPRD;

interacts with

 RASSF1HPRD;

interacts with

 RASSF1MINT;

interacts with

 RB1BIOGRID;

interacts with

 RB1HPRD;

interacts with

 RB1INTACT;

interacts with

 RB1MINT;

interacts with

 RBBP6BIOGRID;

interacts with

 RCHY1BIOGRID;

interacts with

 RFFLHPRD;

interacts with

 RNF34HPRD;

interacts with

 RPL5BIOGRID;

interacts with

 RPL5HPRD;

interacts with

 RPL5INTACT;

interacts with

 RPL5MINT;

interacts with

 RPS27LBIOGRID;

interacts with

 Rps27lINTACT;

interacts with

 RPS27LINTACT;

interacts with

 RPS27BIOGRID;

interacts with

 RPS27INTACT;

interacts with

 RPS6KB1BIOGRID;

interacts with

 RRM2BBIOGRID;

interacts with

 RYBPBIOGRID;

interacts with

 RYBPMINT;

interacts with

 S100A1MINT;

interacts with

 S100A2MINT;

interacts with

 S100A4MINT;

interacts with

 S100A6MINT;

interacts with

 S100BMINT;

interacts with

 SFNBIOGRID;

interacts with

 SFNMINT;

interacts with

 SIVA1BIOGRID;

interacts with

 SNAI1MINT;

interacts with

 SUV39H1BIOGRID;

interacts with

 TAF1BIOGRID;

interacts with

 TAF1HPRD;

interacts with

 TBPBIOGRID;

interacts with

 TBPHPRD;

interacts with

 TCAPHPRD;

interacts with

 Tp53BIOGRID;

interacts with

 TP53BIOGRID;

interacts with

 TP53INTACT;

interacts with

 TP53MINT;

interacts with

 TP63BIOGRID;

interacts with

 TP73BIOGRID;

interacts with

 TP73HPRD;

interacts with

 TRIM28BIOGRID;

interacts with

 TSG101BIOGRID;

interacts with

 TSG101HPRD;

interacts with

 UBE2ABIOGRID;

interacts with

 UBE2D1BIOGRID;

interacts with

 UBE2G2BIOGRID;

interacts with

 UBE2IBIOGRID;

interacts with

 UBE2UBIOGRID;

interacts with

 UBE2ZBIOGRID;

interacts with

 UBQLN4HPRD;

interacts with

 USP10BIOGRID;

interacts with

 USP2HPRD;

interacts with

 USP2MINT;

interacts with

 USP7BIOGRID;

interacts with

 USP7HPRD;

interacts with

 USP7MINT;

interacts with

 YWHAQBIOGRID;

interacts with

 YY1BIOGRID;

interacts with

 ZNF668BIOGRID;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 HDAC2NCI_NATURE;

metabolic catalysis

 SSRP1NCI_NATURE;

metabolic catalysis

 TP53NCI_NATURE;

metabolic catalysis

 TRRAPNCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 AKAP5REACTOME;

reacts with

 DLG1REACTOME;

reacts with

 DLG4REACTOME;

reacts with

 EPB41L1REACTOME;

reacts with

 KAT5NCI_NATURE;

reacts with

 MDM2NCI_NATURE;

reacts with

 MDM2REACTOME;

reacts with

 RPL5NCI_NATURE;

reacts with

 UBE2D1NCI_NATURE;

reacts with

 YY1NCI_NATURE;

state change

 ABL1NCI_NATURE;

state change

 AKT1NCI_NATURE;

state change

 ATMNCI_NATURE;

state change

 ATRIPNCI_NATURE;

state change

 ATRNCI_NATURE;

state change

 CCNA2NCI_NATURE;

state change

 CCNG1NCI_NATURE;

state change

 CDK2NCI_NATURE;

state change

 DAXXNCI_NATURE;

state change

 HUS1NCI_NATURE;

state change

 KAT2BNCI_NATURE;

state change

 MDM4NCI_NATURE;

state change

 PIAS1NCI_NATURE;

state change

 PIAS2NCI_NATURE;

state change

 PPM1DNCI_NATURE;

state change

 PPP2CANCI_NATURE;

state change

 PPP2R4NCI_NATURE;

state change

 RAD17NCI_NATURE;

state change

 RAD1NCI_NATURE;

state change

 RAD9ANCI_NATURE;

state change

 RANBP2NCI_NATURE;

state change

 RANGAP1NCI_NATURE;

state change

 RASSF1NCI_NATURE;

state change

 RFC2NCI_NATURE;

state change

 RFC3NCI_NATURE;

state change

 RFC4NCI_NATURE;

state change

 RFC5NCI_NATURE;

state change

 RPA1NCI_NATURE;

state change

 RPA2NCI_NATURE;

state change

 TOPBP1NCI_NATURE;

state change

 UBE2INCI_NATURE;

state change

 USP7NCI_NATURE;

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