Entrez Gene

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General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information
Gene ID	3569
Name	IL6
Synonymous	interleukin 6;IL6;interleukin 6
Definition	B-cell differentiation factor\|B-cell stimulatory factor 2\|BSF-2\|CDF\|CTL differentiation factor\|IFN-beta-2\|hybridoma growth factor\|interferon beta-2\|interferon, beta 2\|interleukin BSF-2\|interleukin-6
Position	7p21
Gene Type	protein-coding
Gene Interactions:	Physical Interaction Metabolic Interaction Signaling Interaction

Interaction Type	Interactor	Data Source
Physical Interaction [Top]
in same component	HCK	NCI_NATURE;
in same component	IL6R	NCI_NATURE;
in same component	IL6ST	NCI_NATURE;
in same component	JAK1	NCI_NATURE;
in same component	JAK2	NCI_NATURE;
in same component	SOCS3	NCI_NATURE;
in same component	TYK2	NCI_NATURE;
interacts with	IL6R	BIOGRID;
interacts with	IL6R	HPRD;
interacts with	IL6ST	HPRD;
interacts with	PTHLH	HPRD;
interacts with	SH3GL2	BIOGRID;
interacts with	SH3GL2	HPRD;
interacts with	SH3GL2	MINT;
interacts with	ZBTB16	HPRD;
interacts with	ZBTB16	MINT;

Interaction Type	Interactor	Data Source
Metabolic Interaction [Top]
metabolic catalysis	ATF2	NCI_NATURE;
metabolic catalysis	FOSL1	NCI_NATURE;
metabolic catalysis	IL12B	NCI_NATURE;
metabolic catalysis	IL12RB1	NCI_NATURE;
metabolic catalysis	IL23A	NCI_NATURE;
metabolic catalysis	IL23R	NCI_NATURE;
metabolic catalysis	JAK2	NCI_NATURE;
metabolic catalysis	JUNB	NCI_NATURE;
metabolic catalysis	JUN	NCI_NATURE;
metabolic catalysis	NFKB1	NCI_NATURE;
metabolic catalysis	RELA	NCI_NATURE;
metabolic catalysis	TYK2	NCI_NATURE;

Interaction Type	Interactor	Data Source
Signaling Interaction [Top]
reacts with	HCK	NCI_NATURE;
reacts with	IL6	NCI_NATURE;
reacts with	IL6	REACTOME;
reacts with	IL6R	NCI_NATURE;
reacts with	IL6ST	NCI_NATURE;
reacts with	JAK1	NCI_NATURE;
reacts with	JAK2	NCI_NATURE;
reacts with	SOCS3	NCI_NATURE;
reacts with	TYK2	NCI_NATURE;
state change	IL6	REACTOME;

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