Cell senescence gene database Home
Cell senescence database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

4683

Name

NBN

Synonym

AT-V1|AT-V2|ATV|NBS|NBS1|P95;nibrin;NBN;nibrin

Definition

Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex

Position

8q21

Gene Type

protein-coding

Pathways and Diseases

Pathway

Regulation of Telomerase;PID Curated;200072

Pathway

BARD1 signaling events;PID Curated;200174

Pathway

Homologous recombination;KEGG PATHWAY;hsa03440

Pathway

DNA Repair;Reactome;REACT:216

Pathway

role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234

Pathway

Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks;PID Reactome;500950

Pathway

ATM mediated phosphorylation of repair proteins;PID Reactome;500043

Pathway

MRN complex relocalizes to nuclear foci;PID Reactome;500045

Pathway

Validated targets of C-MYC transcriptional activation;PID Curated;200045

Disease

Hereditary disease;FunDO

Disease

Fanconi's anemia;FunDO

Disease

breast cancer;GAD

Disease

Immune system diseases;KEGG DISEASE

Disease

Adenovirus infection;FunDO

Disease

DNA repair defect;KEGG DISEASE;H00094

Disease

CANCER;GAD

Disease

Cancer;FunDO

Disease

Neoplasms;GAD

Disease

Primary immunodeficiency;KEGG DISEASE

Disease

Immunologic deficiency syndrome;FunDO

Disease

Werner syndrome;FunDO

External Links

Links to Entrez Gene

4683

Links to all GeneRIF Items

4683

Links to iHOP

4683

Sequence Information

Nucleotide Sequence

>4683 : length: 4724
AAGCGCCCAAGTCGCACTCCCGCCTCATCCAAGGCAGCCTGCGTGGCTCCCGGGAGCGCG
CACGTCCCGGAGCCCATGCCGACCGCAGGCGCCGTATCCGCGCTCGTCTAGCAGCCCCGG
TTACGCGGTTGCACGTCGGCCCCAGCCCTGAGGAGCCGGACCGATGTGGAAACTGCTGCC
CGCCGCGGGCCCGGCAGGAGGAGAACCATACAGACTTTTGACTGGCGTTGAGTACGTTGT
TGGAAGGAAAAACTGTGCCATTCTGATTGAAAATGATCAGTCGATCAGCCGAAATCATGC
TGTGTTAACTGCTAACTTTTCTGTAACCAACCTGGTATAGAAAAACATTTTGGAAATTTC
TACAGAAAAAGTAAAATTGTTACTAGTCAAACAGATGAAATCCCTGTATTGACATTAAAA
GATAATTCTAAGTATGGTACCTTTGTTAATGAGGAAAAAATGCAGAATGGCTTTTCCCGA
ACTTTGAAGTCGGGGGATGGTATTACTTTTGGAGTGTTTGGAAGTAAATTCAGAATAGAG
TATGAGCCTTTGGTTGCATGCTCTTCTTGTTTAGATGTCTCTGGGAAAACTGCTTTAAAT
CAAGCTATATTGCAACTTGGAGGATTTACTGTAAACAATTGGACAGAAGAATGCACTCAC
CTTGTCATGGTATCAGTGAAAGTTACCATTAAAACAATATGTGCACTCATTTGTGGACGT
CCAATTGTAAAGCCAGAATATTTTACTGAATTCCTGAAAGCAGTTGAGTCCAAGAAGCAG
CCTCCACAAATTGAAAGTTTTTACCCACCTCTTGATGAACCATCTATTGGAAGTAAAAAT
GTTGATCTGTCAGGACGGCAGGAAAGAAAACAAATCTTCAAAGGGAAAACATTTATATTT
TTGAATGCCAAACAGCATAAGAAATTGAGTTCCGCAGTTGTCTTTGGAGGTGGGGAAGCT
AGGTTGATAACAGAAGAGAATGAAGAAGAACATAATTTCTTTTTGGCTCCGGGAACGTGT
GTTGTTGATACAGGAATAACAAACTCACAGACCTTAATTCCTGACTGTCAGAAGAAATGG
ATTCAGTCAATAATGGATATGCTCCAAAGGCAAGGTCTTAGACCTATTCCTGAAGCAGAA
ATTGGATTGGCGGTGATTTTCATGACTACAAAGAATTACTGTGATCCTCAGGGCCATCCC
AGTACAGGATTAAAGACAACAACTCCAGGACCAAGCCTTTCACAAGGCGTGTCAGTTGAT
GAAAAACTAATGCCAAGCGCCCCAGTGAACACTACAACATACGTAGCTGACACAGAATCA
GAGCAAGCAGATACATGGGATTTGAGTGAAAGGCCAAAAGAAATCAAAGTCTCCAAAATG
GAACAAAAATTCAGAATGCTTTCACAAGATGCACCCACTGTAAAGGAGTCCTGCAAAACA
AGCTCTAATAATAATAGTATGGTATCAAATACTTTGGCTAAGATGAGAATCCCAAACTAT
CAGCTTTCACCAACTAAATTGCCAAGTATAAATAAAAGTAAAGATAGGGCTTCTCAGCAG
CAGCAGACCAACTCCATCAGAAACTACTTTCAGCCGTCTACCAAAAAAAGGGAAAGGGAT
GAAGAAAATCAAGAAATGTCTTCATGCAAATCAGCAAGAATAGAAACGTCTTGTTCTCTT
TTAGAACAAACACAACCTGCTACACCCTCATTGTGGAAAAATAAGGAGCAGCATCTATCT
GAGAATGAGCCTGTGGACACAAACTCAGACAATAACTTATTTACAGATACAGATTTAAAA
TCTATTGTGAAAAATTCTGCCAGTAAATCTCATGCTGCAGAAAAGCTAAGATCAAATAAA
AAAAGGGAAATGGATGATGTGGCCATAGAAGATGAAGTATTGGAACAGTTATTCAAGGAC
ACAAAACCAGAGTTAGAAATTGATGTGAAAGTTCAAAAACAGGAGGAAGATGTCAATGTT
AGAAAAAGGCCAAGGATGGATATAGAAACAAATGACACTTTCAGTGATGAAGCAGTACCA
GAAAGTAGCAAAATATCTCAAGAAAATGAAATTGGGAAGAAACGTGAACTCAAGGAAGAC
TCACTATGGTCAGCTAAAGAAATATCTAACAATGACAAACTTCAGGATGATAGTGAGATG
CTTCCAAAAAAGCTGTTATTGACTGAATTTAGATCACTGGTGATTAAAAACTCTACTTCC
AGAAATCCATCTGGCATAAATGATGATTATGGTCAACTAAAAAATTTCAAGAAATTCAAA
AAGGTCACATATCCTGGAGCAGGAAAACTTCCACACATCATTGGAGGATCAGATCTAATA
GCTCATCATGCTCGAAAGAATACAGAACTAGAAGAGTGGCTAAGGCAGGAAATGGAGGTA
CAAAATCAACATGCAAAAGAAGAGTCTCTTGCTGATGATCTTTTTAGATACAATCCTTAT
TTAAAAAGGAGAAGATAACTGAGGATTTTAAAAAGAAGCCATGGAAAAACTTCCTAGTAA
GCATCTACTTCAGGCCAACAAGGTTATATGAATATATAGTGTATAGAAGCGATTTAAGTT
ACAATGTTTTATGGCCTAAATTTATTAAATAAAATGCACAAAACTTTGATTCTTTTGTAT
GTAACAATTGTTTGTTCTGTTTTCAGGCTTTGTCATTGCATCTTTTTTTCATTTTTAAAT
GTGTTTTGTTTATTAAATAGTTAATATAGTCACAGTTCAAAATTCTAAATGTACGTAAGG
TAAAGACTAAAGTCACCCTTCCACCATTGTCCTAGCTACTTGGTTCCCCTCAGAAAAAAA
TTCATGATACTCATTTCTTATGAATCTTTCCAGGGATTTTTGAGTCCTATTCAAATTCCT
ATTTTTAAATAATTTCCTACACAAATGATAGCATAACATATGCAGTGTTCTACACCTTGC
TTTTTTACTTAGTAGATTAAAAATTATAGGAATATCAATATAATGTTTTTAATATTTTTT
CTTTTCCATTATGCTGTAGTCTTACCTAAACTCTGGTGATCCAAACAAAATGGCTTCAGT
GGTGCAGATGTCACCTACATGTTATTCTAGTACTAGAAACTGAAGACCATGTGGAGACTT
CATCAAACATGGGTTTAGTTTTCACCAGAATGGAAAGACCTGTACCCCTTTTTGGTGGTC
TTACTGAGCTGGGTGGGTGTCTGTTTTGAGCTTATTTAGAGTCCTAGTTTTCCTACTTAT
AAAGTAGAAATGGTGAGATTGTTTTCTTTTTCTACCTTAAAGGGAGATGGTAAGAAACAA
TGAATGTCTTTTTTCAAACTTTATTGACAAGTGATTTTCAAGTCTGTGTTCAAAAATATA
TTCATGTACCTGTGATCCAGCAAGAAGGGAGTTCCAGTCAAGAGTCACTACAACTGATTA
GTTGTTTAGAGAATGAGAAATGGAACAGTGAGGAATGGAGGCCATATTTCCATGACTTCC
CTTGTAAACAGAAGCAACAGAAGGGACAAGAGGCTGGCCTCTACATCACTCTCACCTTCC
AAATCTTGTGGAAGTGCATCTACTTGCCAGAACCAAATTAACTTACTTCCAAGTTCTGGC
TGCTTGCAGGTGGAACTCCAGCTGCAAGGGAGTTAGGGAAATGAAGGTCTTTTTTTAAAA
GCTTCTCAGCCTTCCTAGGGAACAGAAATTGGGTGAGCCAATCTGCAATTTCTACTACAG
GCATTGAGACCAGTTAGATTATTGAAATATTATAGAGAGTTATGAACACTTAAATTATGA
TAGTGGTATGACATTGGATAGAACATGGGATACTTTAGAAGTAGAATTGACAGGGCATAT
TAGTTGATGAAATGGAGTCATTTGAGTCTCTTAATAGCCATGTATCATAATTACCAAGTG
AAGCTGGTGGAACATATGGTCTCCATTTTACAGTTAAGGAATATAATGGACAGATTAATA
TTGTTCTCTGTCATGCCCACAATCCCTTTCTAAGGAAGACTGCCCTACTATAGCAGTTTT
TATATTTGTCAATTTATGAATATAATGAATGAGAGTTCTGGTACCTCCTGTCTTTACAAA
TATTGGTGTTGTCAGTATTTTTCCTTTTTAACCATTCCAATCGGTGTGTAGTGATGTTTC
ATTTTGGTTTTAATTTGTATATCCCTGATAGCTATAATTGGGTCATAGAAATTCTTTATA
CATTCTAGATGCAAGTCTCTTGTCGGATATATGTATTGAGATATTACACCTAGTCTGTGG
CTTGACTGTTTTCTTTATGTCTTTTGATGAATAGAAGTTTTAAATTTTGACAAGGTCAAA
TTTATTTTTTTCTTTTGTTTGATATTTTTTCTCTCCAATTTAACCCCAAGATTTCAGATA
TTCTGCTCTATTATATAAACTTTATATTTTTATATTTGTGATCTACCTTGAATTGATATG
TATGTTGTGAATTATGGATCAGGGTTCTTTTTTTCCCCCATACAAGTATCCAGTCATTGT
AACACTGTTTATTGAAAGAATTATCCTTTCCTCATTAAATTACCTTGCCAATTAGTAAAA
AATCAATTAACCATAATGGTGGATCTGTTTCTGGACTTTCTGTTTGGTTACACTGAAATG
TTTGTCCATCCTTGCACTCACTCATACCATACTGCCTTGAATTACTGTAGCTGCATAGAT
GCTCCTTAAGTTGGGATTACATTGTAATAAACGCAATGTAAGTT

Protein Sequence

>4683 : length: 754
MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQT
DEIPVLTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVFGSKFRIEYEPLVACSSCL
DVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEF
LKAVESKKQPPQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSS
AVVFGGGEARLITEENEEEHNFFLAPGTCVVDTGITNSQTLIPDCQKKWIQSIMDMLQRQ
GLRPIPEAEIGLAVIFMTTKNYCDPQGHPSTGLKTTTPGPSLSQGVSVDEKLMPSAPVNT
TTYVADTESEQADTWDLSERPKEIKVSKMEQKFRMLSQDAPTVKESCKTSSNNNSMVSNT
LAKMRIPNYQLSPTKLPSINKSKDRASQQQQTNSIRNYFQPSTKKRERDEENQEMSSCKS
ARIETSCSLLEQTQPATPSLWKNKEQHLSENEPVDTNSDNNLFTDTDLKSIVKNSASKSH
AAEKLRSNKKREMDDVAIEDEVLEQLFKDTKPELEIDVKVQKQEEDVNVRKRPRMDIETN
DTFSDEAVPESSKISQENEIGKKRELKEDSLWSAKEISNNDKLQDDSEMLPKKLLLTEFR
SLVIKNSTSRNPSGINDDYGQLKNFKKFKKVTYPGAGKLPHIIGGSDLIAHHARKNTELE
EWLRQEMEVQNQHAKEESLADDLFRYNPYLKRRR



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